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Image-based methods for measuring global nuclear patterns as epigenetic markers of cell differentiation 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G06K-009/00
출원번호 US-0321360 (2009-01-16)
등록번호 US7907769 (2011-03-01)
발명자 / 주소
  • Sammak, Paul J.
  • Mangoubi, Rami
  • Desai, Mukund
  • Erb, Teresa M.
  • Lowry, Nathan
출원인 / 주소
  • The Charles Stark Draper Laboratory, Inc.
  • University of Pittsburgh - Of the Commonwealth System of Higher Education
대리인 / 주소
    Ropes & Gray LLP
인용정보 피인용 횟수 : 39  인용 특허 : 0

초록

The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell colonies, individual cells, and/or cellular structures.

대표청구항

We claim: 1. A method for determining a characteristic of one or more test cells, comprising:(a) obtaining an image of one or more test cells;(b) representing said image as a multiplicity of pixels;(c) using a processor to extract one or more image features from said multiplicity of pixels, wherein

이 특허를 인용한 특허 (39)

  1. Ducksbury, Paul Gerard; Varga, Margaret Jai, Automated selection of image regions.
  2. Garini, Yuval; Bronshtein Berger, Irena; Kepten, Eldad, Cell analysis using dynamic biophysical methods.
  3. Amakawa, Genta; Takagi, Kosuke; Matsuo, Yuichiro, Cell-image analyzing apparatus.
  4. Fuxman, Adrian Matias; Pachner, Daniel, Condition-based powertrain control system.
  5. Stewart, Greg; Borrelli, Francesco; Pekar, Jaroslav, Configurable automotive controller.
  6. Stewart, Greg; Pekar, Jaroslav; Pachner, Daniel, Coordinated engine and emissions control system.
  7. Jahanbin, Sina; Bovik, Alan C.; Perez, Eduardo; Nair, Dinesh, Detection of textural defects using a one class support vector machine.
  8. Mangan, Steven L.; Jonas, Gary, Determining pathogens based on an image of somatic cells in a fluid sample.
  9. Cheng, Ming-Hui; Chen, Yan-Jun; Yu, Tsung-Chih; Pan, Bo-Wei; Wu, Chun-Sen, Device and method for finding cell nucleus of target cell from cell image.
  10. Pachner, Daniel; Pekar, Jaroslav, Engine and aftertreatment optimization system.
  11. Stewart, Gregory E.; Rhodes, Michael L., Engine controller.
  12. Trumbull, Jonathan D.; Gintant, Gary A.; Kantor, Stanislaw; Pan, Jeffrey Yen; Diaz, Gilbert J.; Green, Jonathon; Su, Zhi; Olson, Jeffrey A., High throughput, optical method and system for determining the effect of a test substance on non-contiguous living cells.
  13. Pachner, Daniel, Identification approach for internal combustion engine mean value models.
  14. Ozaki, Ryota; Kato, Noriji; Oda, Hideto; Kumazawa, Yukio, Image processing device, computer storage medium, and method for detecting and displaying nucleated target cells.
  15. George, Thaddeus C.; Basiji, David A.; Frost, Keith; Hall, Brian E.; Ortyn, William E.; Seo, Michael J., Image-based quantitation of molecular translocation.
  16. Watakabe, Keizo; Nakamura, Yohichi; Ohji, Osamu; Nakashima, Katsumi, Method and apparatus for discriminating undifferentiated pluripotent stem cells, and automated culture method and system.
  17. Heismann, Björn; Hengerer, Arne; Schmidt, Sebastian, Method and device for determining a change over time in a biomarker in a region to be examined.
  18. Kihas, Dejan, Method and system for updating tuning parameters of a controller.
  19. Kihas, Dejan, Method and system for updating tuning parameters of a controller.
  20. Fujimoto, Hiroki; Moriwaki, Sanzo, Method for evaluating culture quality.
  21. Ghosh, Nirmalya; Ashwal, Stephen; Obenaus, Andre; Bhanu, Bir, Method of analyzing a medical image.
  22. Ghosh, Nirmalya; Ashwal, Stephen; Obenaus, Andre; Bhanu, Bir, Method of analyzing a medical image.
  23. Sammak, Paul J.; Mangoubi, Rami; Erb, Teresa M.; Mucko, Sara; Desai, Mukund, Methods of generating trophectoderm and neurectoderm from human embryonic stem cells.
  24. Maresh, Guy; Yu, Jeffrey N., Methods, systems, and devices for controlling a permission-based workflow process for transferring medical files.
  25. Maresh, Guy; Yu, Jeffrey N., Methods, systems, and devices for managing medical files.
  26. Maresh, Guy; Yu, Jeffrey N., Methods, systems, and devices for managing medical images and records.
  27. Yu, Jeffrey N., Methods, systems, and devices for managing medical images and records.
  28. Yu, Jeffrey N.; Branson, David, Methods, systems, and devices for managing medical images and records.
  29. Maresh, Guy; Yu, Jeffrey N., Methods, systems, and devices for managing transfer of medical files.
  30. Maresh, Guy; Yu, Jeffrey N., Methods, systems, and devices for modifying medical files.
  31. Maresh, Guy; Yu, Jeffrey N., Methods, systems, and devices for transferring medical files.
  32. Maresh, Guy; Yu, Jeffrey N., Methods, systems, and devices for transferring medical files from a source facility to a destination facility.
  33. Maresh, Guy; Yu, Jeffrey N., Methods, systems, and devices for verifying and approving government required release forms.
  34. Needleman, Daniel; Deng, Manqi; Sanchez, Timothy H., Non-linear imaging systems and methods for assisted reproductive technologies.
  35. Lee, Shih-Jong J.; Alworth, Samuel V., Progressive decision for cellular process selection.
  36. Freedman, Daniel, Segmenting an image.
  37. Zeng, Wen-Jun; So, Hing Cheung; Chen, Jiayi, Systems and methods for robust low-rank matrix approximation.
  38. Pekar, Jaroslav; Stewart, Gregory E., Using model predictive control to optimize variable trajectories and system control.
  39. Markham, Thomas R., Vehicle security module system.
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