초록 ▼

The present invention recognizes that the determination of ion transport function or property using direct detection methods, such as patch-clamps, whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system

The present invention recognizes that the determination of ion transport function or property using direct detection methods, such as patch-clamps, whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and methods of use that allow for the direct analysis of ion transport function or property using microfabricated structures that can allow for automated detection of ion transport function or property. These biochips and methods of use thereof are particularly appropriate for automating the detection of ion transport function or property, particularly for screening purposes.

대표청구항 ▼

What is claimed is: 1. A biochip system comprising:a) a biochip comprising at least two horizontal fluidic channels;b) an ion transport measuring means that comprises a vertical hole through said biochip in fluid communication with said horizontal fluidic channels; andc) at least one horizontal part

What is claimed is: 1. A biochip system comprising:a) a biochip comprising at least two horizontal fluidic channels;b) an ion transport measuring means that comprises a vertical hole through said biochip in fluid communication with said horizontal fluidic channels; andc) at least one horizontal particle positioning means comprising a pressure generation structure;wherein said horizontal particle positioning means positions a particle or a population of particles relative to the X-Y coordinates of said biochip at or near said vertical hole.