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Portable scattering and fluorescence cytometer 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-021/00
출원번호 US-0304773 (2002-11-26)
등록번호 US7978329 (2011-06-28)
발명자 / 주소
  • Padmanabhan, Aravind
  • Cabuz, Cleopatra
  • Fritz, Bernard S.
출원인 / 주소
  • Honeywell International Inc.
대리인 / 주소
    Seager, Tufte & Wickhem LLC
인용정보 피인용 횟수 : 12  인용 특허 : 70

초록

An apparatus having scattering and multi-color fluorescence detecting, analyzing and identification capabilities of blood or other fluids of interest. The sample to be tested may be entered in a disposable microfluidic cartridge which in turn is insertable in a hand-holdable or implantable miniaturi

대표청구항

What is claimed is: 1. A portable apparatus, comprising:a removable cartridge defining a flow stream path containing at least one particle having a fluorescent marker; anda portable housing adapted to receive the removable cartridge, said portable housing including:a first light source arrangement d

이 특허에 인용된 특허 (70)

  1. Yager Paul ; Brody James P., Absorption-enhanced differential extraction device.
  2. Ohnstein Thomas R. ; Cabuz Eugen I., Addressable valve arrays for proportional pressure or flow control.
  3. Nakamoto Hiroyuki,JPX ; Katayama Masayuki,JPX, Analyzer for analyzing particle components in urine with flow cytometry.
  4. Tycko Daniel H. (P.O. Box 1033 Stony Brook NY 11790), Apparatus and method for measuring volume and hemoglobin concentration of red blood cells.
  5. Kosaka Tokihiro (Kakogawashi JPX), Apparatus for analyzing particles in fluid samples.
  6. Igushi Tatsuo (Kyoto JPX) Togawa Yoshiaki (Kyoto JPX), Apparatus for simultaneously measuring large and small particle size distribution.
  7. Cabuz Cleopatra ; Ohnstein Thomas R. ; Herb William R., Buckled actuator with enhanced restoring force.
  8. Munk Miner N., Capillary flow cell with bulbous ends.
  9. Blum Arnold (Gechingen DEX) Perske Manfred (Sindelfingen DEX) Schmidt Manfred (Schnaich DEX), Cascade compressor.
  10. Landa Benzion (Edmonton CAX) Niv Yehuda (Rehovot ILX) Plotkin Michael (Kibbutz Einat ILX) Forgacs Peter (Kiryat Gat ILX), Concentration detector for colored toner.
  11. Saaski Elric W., Disposable fluidic circuit cards.
  12. Cabuz Cleopatra ; Cabuz Eugen I., Driving strategy for non-parallel arrays of electrostatic actuators sharing a common electrode.
  13. Herb William R. ; Zook J. David ; Cabuz Cleopatra, Dual diaphragm, single chamber mesopump.
  14. Bonne Ulrich (4936 Shady Oak Rd. Hopkins MN 55343) Ohnstein Thomas R. (1944 Hythe St. Roseville MN 55113), Electronic microvalve apparatus and fabrication.
  15. Cabuz Cleopatra ; Ohnstein Thomas R. ; Elgersma Michael R., Electrostatic/pneumatic actuators for active surfaces.
  16. Cabuz Cleopatra, Electrostatically actuated mesopump having a plurality of elementary cells.
  17. King David A. (Palo Alto CA) Seher Jens-Peter (Stuttgart DEX), Evanescent scanning of biochemical array.
  18. Ohnstein Thomas R. (Roseville MN), Fabrication of an electronic microvalve apparatus.
  19. Hibbs-Brenner Mary K. ; Biard James R., Fabrication of vertical cavity surface emitting laser with current confinement.
  20. Bohrer Philip J. (Minneapolis MN), Flow sensor.
  21. Bohrer Philip J. (Minneapolis MN) Johnson Robert G. (Minneapolis MN), Flow sensor.
  22. Higashi Robert E. (Minneapolis MN) Johnson Robert G. (Minneapolis MN) Bohrer Philip J. (Minneapolis MN), Flow sensor.
  23. Curbelo Raul (Lexington MA), Flow stream processor.
  24. Shimizu Tetsuo (Kyoto JPX) Tujimura Kiyoharu (Kyoto JPX) Iwamoto Michinori (Kyoto JPX), Fluid control device.
  25. Cleopatra Cabuz ; J. David Zook ; Thomas Raymond Ohnstein ; Ulrich Bonne ; Eugen Loan Cabuz ; Ernest Allen Satren, Fluid driving system for flow cytometry.
  26. Zengerle Roland,DEX ; Stehr Manfred,DEX ; Messner Stephan,DEX, Fluid pump.
  27. Johnson Greg P. (1081 N. Allumbaugh #105 Boise ID 83704), Hardware mounting rail.
  28. Cabuz Cleopatra ; Ohnstein Thomas R. ; Cabuz Eugen I., Hydrophobic coating for reducing humidity effect in electrostatic actuators.
  29. Sun Xiaoguong ; Joseph Jeffrey I. ; Crothall Katherine D., Implantable sensor and system for measurement and control of blood constituent levels.
  30. Tsai Ming-Jye,TWX ; Wan Yue-Min,TWX ; Ke Chun-Hsu,TWX ; Jang Ruei-Hung,TWX ; Wu Ching-Yi,TWX ; Huang Raey-Shing,TWX ; Peng Cheng-Jien,TWX, Integrated flow controller module.
  31. Chandler Van S., Interlaced lasers for multiple fluorescence measurement.
  32. Cabuz Cleopatra, Low cost, high pumping rate electrostatically actuated mesopump.
  33. Hansen W. Peter (Middleboro MA) Hoffman Robert A. (Mansfield MA), Method and apparatus for automated identification and enumeration of specified blood cell subclasses.
  34. Ito Yuji,JPX ; Toge Yoshiyuki,JPX ; Saito Atsushi,JPX ; Yamazaki Tatsuya,JPX ; Miyamoto Moritoshi,JPX, Method and apparatus for optically measuring specimen.
  35. Maltsev Valeri Pavlovich (Novosibirsk RUX) Chernyshev Andrei Vitalievich (Novosibirsk RUX), Method and device for determination of parameters of individual microparticles.
  36. Marowsky, Gerd; Neuschaefer, Dieter; Pawlak, Michael, Method and device for measuring luminescence.
  37. Forster Fred K. ; Galambos Paul C. ; Weigl Bernhard H. ; Holl Mark R., Method for determining concentration of a laminar sample stream.
  38. Harris Thomas R. (Nashville TN) Galloway ; Jr. Robert L. (Nashville TN), Method of measuring lung vascular function and transcapillary transport by the use of nonradioactive markers.
  39. Hennel Ewald (Mecklenheidestrasse 61 D-3000 Hannover 21 DEX), Method of setting the output of a pump.
  40. Laumann ; Jr. Carl W. (6926 301 Blvd. Sarasota FL 34243), Micro miniature implantable pump.
  41. Maillefer Didier,CHX ; Renaud Philippe,CHX, Micro-machined device for fluids and method of manufacture.
  42. Nishimoto Ikuo (Kanagawa JPX) Kurosawa Takashi (Kanagawa JPX) Yamamoto Tomoshige (Kanagawa JPX), Microbridge flow sensor.
  43. Lievan Bonnie A., Microchip optical transport technology for use in a personal flow cytometer.
  44. Yager Paul ; Brody James P. ; Holl Mark R. ; Forster Fred K. ; Galambos Paul C., Microfabricated differential extraction device and method.
  45. Weigl Bernhard H. ; Yager Paul ; Brody James P. ; Holl Mark R. ; Kenny Margaret ; Schutte David ; Hixson Gregory ; Zebert M. Diane ; Kamholz Andrew ; Wu Caicai ; Altendorf Eric, Microfabricated diffusion-based chemical sensor.
  46. Yager Paul ; Weigl Bernhard H. ; Brody James P ; Holl Mark R., Microfabricated diffusion-based chemical sensor.
  47. Weinberg Marc S. (Needham MA), Microfabricated pump.
  48. van Lintel Harald (Martigny CHX), Micropump having a constant output.
  49. van Lintel Harald T. G. (Enschede NLX), Micropump with improved priming.
  50. Bonne Ulrich (Hopkins MN) Ohnstein Thomas R. (Roseville MN), Microstructure gas valve control.
  51. Bonne Ulrich (Hopkins MN) Ohnstein Thomas R. (Roseville MN), Microstructure gas valve control.
  52. Bonne Ulrich (Hopkins MN) Ohnstein Thomas R. (Roseville MN), Microstructure gas valve control forming method.
  53. Gravesen Peter (Nordborg DKX) Branebjerg Jens A. (N rum DKX), Miniature actuating device.
  54. Cangelosi Jerome M. (Mentor-On-The-Lake OH) Zgonc James (Willowick OH), Moving web filter assembly.
  55. Norton Pierce Owen ; Hoffman Robert A., Multi-illumination-source flow particle analyzer with inter-location emissions crosstalk cancelation.
  56. Yager Paul, Multiple analyte diffusion based chemical sensor.
  57. Cabuz, Cleopatra; Zook, J. David; Cox, James Allen; Padmanabhan, Aravind; Marta, Teresa M., Optical detection system for flow cytometry.
  58. Southgate Peter David ; Andrevski Zygmunt Marian ; Roach William Ronald ; Zanzucchi Peter John, Parallel reaction cassette and associated devices.
  59. Jiang, Yanan, Portable spectral imaging microscope system.
  60. Beatty Christopher C. (Fort Collins CO), Pump apparatus.
  61. Gourley Paul L., Resonant-cavity apparatus for cytometry or particle analysis.
  62. Rodriguez Carlos M. (Miami FL) Ledis Stephen L. (Hialeah FL), Reticulocyte analyzing method and apparatus utilizing light scatter techniques.
  63. Johnson Robert G. (Hennepin MN) Higashi Robert E. (Hennepin MN), Semiconductor device.
  64. Bohrer Philip J. (Minneapolis MN) Higashi Robert E. (Bloomington MN) Johnson Robert G. (Minnetonka MN), Semiconductor device structure and processing.
  65. Brenner Mary K., Semiconductor device with a laser and a photodetector in a common container.
  66. Altendorf Eric H. ; Yager Paul, Silicon microchannel optical flow cytometer.
  67. Weigl Bernhard H. ; Holl Mark R. ; Zebert Diane ; Kenny Margaret ; Wu Caicai, Simultaneous analyte determination and reference balancing in reference T-sensor devices.
  68. Brody James P. ; Osborn Thor D., Tangential flow planar microfabricated fluid filter and method of using thereof.
  69. van Lintel Harald T. G. (Enschede NLX), Two valve micropump with improved outlet.
  70. Miyazaki Hajime (Suwa JPX) Handa Masaaki (Suwa JPX) Uehara Taisuke (Suwa JPX) Muranaka Tsukasa (Suwa JPX) Kamisuki Shinichi (Suwa JPX) Nose Yasuto (Suwa JPX), Two-valve thin plate micropump.

이 특허를 인용한 특허 (12)

  1. Wardlaw, Stephen C., Apparatus for performing counts within a biologic fluid sample.
  2. Phan, Vu; Verrant, John A.; Blum, John; Verma, Kaushal K.; Edson, Elise G., Biologic fluid analysis cartridge.
  3. Verrant, John A.; Blum, John N.; Phan, Vu; Verma, Kaushal K.; Edson, Elise G., Biologic fluid analysis cartridge.
  4. Verrant, John A.; Lalpuria, Niten V.; Nikonorov, Igor; Unfricht, Darryn W.; Ports, Benjamin; Wardlaw, Stephen C.; Levine, Robert A.; Holt, Robert; Hukari, Kyle, Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion.
  5. Hukari, Kyle; Nikonorov, Igor; Dowdell, Ralph W.; Olson, Douglas; Lalpuria, Niten V.; Unfricht, Darryn; Ports, Benjamin; Phan, Vu; Levy, Robin A.; Roche, John W., Biologic fluid sample analysis cartridge.
  6. Cook, Richard Alan; Cho, Sang; Davis, Charles Quentin; Dorsey, Kevin E; Harley, Jason Charles; Leland, Jonathan; Matikyan, Rober Krikor; Otten, Sjef; Peterman, Jeffrey Howard; Thomas, Brian B, Clinical diagnostic system including instrument and cartridge.
  7. Cook, Richard Alan; Cho, Sang; Davis, Charles Quentin; Dorsey, Kevin E; Harley, Jason Charles; Leland, Jonathan; Matikyan, Rober Krikor; Otten, Sjef; Peterman, Jeffrey Howard; Thomas, Brian B, Clinical diagnostic systems.
  8. Cook, Richard Alan; Davis, Charles Quentin; Harley, Jason Charles; Leland, Jonathan; Matikyan, Rober Krikor; Peterman, Jeffrey Howard, Diagnostic systems and cartridges.
  9. Cook, Richard Alan; Cho, Sang; Davis, Charles Quentin; Dorsey, Kevin E; Harley, Jason Charles; Leland, Jonathan; Matikyan, Rober Krikor; Otten, Sjef; Peterman, Jeffrey Howard; Thomas, Brian B, Diagnostic systems and instruments.
  10. Rowlen, Kathy L.; Ferris, Matthew, Flow measurement and control for improved quantification of particles in flow cytometry.
  11. Bardell, Ronald; Shonkwiler, Jeffrey, Micro-molded cytometer cartridge with integrated optics.
  12. Padmanabhan, Aravind; Cox, James A.; Cabuz, Cleopatra, Portable sample analyzer cartridge.
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