초록 ▼

An implantable medical device is provided for use with an external detector to detect an analyte in vivo. In one embodiment, the device consisting essentially of a substrate; a plurality of discrete reservoirs located in the substrate, each reservoir having at least one opening; a reacting component

An implantable medical device is provided for use with an external detector to detect an analyte in vivo. In one embodiment, the device consisting essentially of a substrate; a plurality of discrete reservoirs located in the substrate, each reservoir having at least one opening; a reacting component contained in each reservoir; and at least one non-degradable barrier layer covering each reservoir opening, the barrier layer being permeable to an analyte to be detected, wherein the reacting component remains inside the reservoirs and can react with the analyte to be detected, and wherein the device is adapted for implantation into the body of a patient.

대표청구항 ▼

We claim: 1. An implantable medical device for use in analyte detection consisting essentially of:a substrate;a plurality of discrete reservoirs located in the substrate, each reservoir having at least one opening;at least one reacting component contained in each reservoir;at least one non-degradabl

We claim: 1. An implantable medical device for use in analyte detection consisting essentially of:a substrate;a plurality of discrete reservoirs located in the substrate, each reservoir having at least one opening;at least one reacting component contained in each reservoir;at least one non-degradable barrier layer covering each reservoir opening, the barrier layer being permeable to an analyte to be detected, wherein the at least one non-degradable barrier layer comprises a semi-permeable polymeric membrane;wherein the reacting component remains inside the reservoirs and can undergo a binding reaction with the analyte to be detected, the binding reaction being detectable by a sensor positioned outside of the device; andat least one degradable barrier layer covering each reservoir opening, wherein said degradable barrier layer is adapted to degrade in vivo to permit said binding reaction to occur.