초록

Disclosed are body-implantable, appropriately absorbable, biocompatible, putty-like compositions useful as mechanical hemostatic tamponades for the control of osseous hemorrhage arising from surgical intervention or trauma and for providing an osteoinductive matrix to foster improved bone healing.

대표청구항 ▼

What is claimed is: 1. A body-absorbable, mechanically hemostatic putty composition having no added water and consisting essentially of an intimate admixture of the following Components 1 and 2 and none, or any one or more, of the following Optional Components:(1) an absorbable, finely powdered, car

What is claimed is: 1. A body-absorbable, mechanically hemostatic putty composition having no added water and consisting essentially of an intimate admixture of the following Components 1 and 2 and none, or any one or more, of the following Optional Components:(1) an absorbable, finely powdered, carboxylic acid salt having a carboxylate anion, and a metallic cation, in intimate admixture with,(2) an absorbable composition that is liquid at room temperature comprising a first member that consists of a liquid at room temperature selected from the group consisting of tocopherol, a C2-C10 aliphatic monocarboxylic acid ester of tocopherol, a polycarboxylic acid ester of tocopherol, and mixtures thereof, and a second member that is consists of a block copolymer of ethylene oxide and propylene oxide wherein the block copolymer is liquid at room temperature,(3) an optional absorbable anti-infective agent, and(4) an optional absorbable colorant,wherein the amounts of Components 1 and 2 and any Optional Components that may be present are sufficient to form a putty-like consistency at ambient temperature, and wherein Component 2 makes up 10-70% of the composition by weight and the first member makes up 4-5% of the composition by weight.