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Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/02
출원번호 US-0454616 (2006-06-16)
등록번호 US7999088 (2011-08-03)
발명자 / 주소
  • Qiu, Zhiyong
  • Bot, Adrian Ion
출원인 / 주소
  • MannKind Corporation
대리인 / 주소
    Davis Wright Tremaine LLP
인용정보 피인용 횟수 : 0  인용 특허 : 58

초록

The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or a cross-reactive analogue. In embodiments of the present

대표청구항

The invention claimed is: 1. An engineered nucleic acid construct encoding a polypeptide comprising: a cross-reactive analogue differing from CTL epitope PSMA288-297 (SEQ ID NO:6) by only 1-3 substitutions, wherein the cross-reactive analogue of CTL epitope PSMA288-297 (SEQ ID NO:6) comprises an I29

이 특허에 인용된 특허 (58)

  1. Wang Rong-Fu ; Rosenberg Steven A., Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein.
  2. Simard,John J. L.; Diamond,David C., Anti-neovasculature preparations for cancer.
  3. Philip E. Thorpe ; Rolf A. Brekken, Antibody conjugate compositions for selectively inhibiting VEGF.
  4. Levy, John, Avoidance of undesirable replication intermediates in plasmid propagation.
  5. Levy,John, Avoidance of undesirable replication intermediates in plasmid propagation.
  6. Stolk, John A.; Molesh, David Alan; Fling, Steven P.; Xu, Jiangchun, Compositions and methods for the therapy and diagnosis of ovarian cancer.
  7. Duff, Gordon W.; di Giovine, Francesco S.; Barnes, Peter J.; Lim, Samson, Diagnostics and therapeutics for an obstructive airway disease.
  8. Simard,John J. L.; Diamond,David C.; Qiu,Zhiyong; Lei,Xiang Dong, Expression vectors encoding epitopes of target-associated antigens and methods for their design.
  9. Au-Young Janice, Human stem cell antigens.
  10. Cheever Martin A. ; Disis Mary L., Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated.
  11. Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Induction of a protective immune response in a mammal by injecting a DNA sequence.
  12. Valmori Danila,CHX ; Cerottini Jean-Charles,CHX ; Romero Pedro,CHX, Isolated nona- and decapeptides which bind to HLA molecules, and the use thereof.
  13. Israeli Ron S. ; Heston Warren D. W. ; Fair William R., Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof.
  14. Chen Yao-tseng ; Scanlan Matthew ; Gure Ali ; Old Lloyd J., Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof.
  15. Chen Yao-tseng ; Scanlan Matthew ; Gure Ali ; Old Lloyd J. ; Jager Elke,DEX ; Alexander Knuth,DEX ; Drijfhout Jan W.,NLX ; Tureci Ozlem,DEX ; Sahin Ugur,DEX ; Pfreundschuh Michael,DEX, Isolated nucleic acid molecule encoding cancer associated antigen, the antigen itself, and uses thereof.
  16. van der Bruggen Pierre (Brussels BEX) Boon-Falleur Thierry (Brussels BEX) Coulie Pierre (Brussels BEX) Renauld Jean-Christophe (Brussels BEX), Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors.
  17. Coulie Pierre,BEX ; Ikeda Hideyuki,BEX ; Boon-Falleur Thierry,BEX, Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof..
  18. Pfreundschuh Michael,DEX, Isolated nucleic acid molecules which encode a melanoma specific antigen and uses thereof.
  19. Brichard Vincent (Brussels BEX) Van Pel Aline (Brussels BEX) Traversari Catia (Milan ITX) Wolfel Thomas (Mainz DEX) Boon-Falleur Thierry (Brussels BEX) De Plaen Etienne (Brussels BEX), Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection.
  20. Tureci, Ozlem; Sahin, Ugur; Pfreundschuh, Michael; Rammensee, Hans Georg; Stevanovic, Stefan, Isolated peptides consisting of amino acid sequences found in SSX or NY-ESO-1 molecules, which bind to HLA molecules.
  21. van der Bruggen Pierre,BEX ; van den Eynde Benoit,BEX ; DeBacker Olivier,BEX ; Boon-Falleur Thierry,BEX, Isolated peptides derived from the gage tumor rejection antigen precursor and uses thereof.
  22. Van den Eynde Benoit (Brussels BEX) DeBacker Olivier (Brussels BEX) Boon-Falleur Thierry (Brussels BEX), Isolated peptides derived from tumor rejection antigens, and their use.
  23. DeBacker Olivier,BEX ; van den Eynde Benoit,BEX ; Boon-Falleur Thierry,BEX, Isolated, nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof.
  24. Van den Eynde Benoit,BEX ; DeBacker Olivier,BEX ; Boon-Falleur Thierry,BEX, Isolated, truncated nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof.
  25. Rimoldi Donata,CHX ; Jongeneel Victor,CHX ; Coulie Pierre,BEX ; Cerrottini Jean-Charles,CHX ; Carrel Stefan,CHX ; Reed Daryl,CHX, MAGE-10 encoding cDNA, the tumor rejection antigen precursor MAGE-10, antibodies specific to the molecule, and uses thereof.
  26. Liu, Liping; Bot, Adrian; Diamond, David C., Melanoma antigen peptide analogues.
  27. Kawakami Yutaka ; Rosenberg Steven A., Melanoma antigens and their use in diagnostic and therapeutic methods.
  28. Kawakami Yutaka ; Rosenberg Steven A., Melanoma antigens and their use in diagnostic and therapeutic methods.
  29. Kawakami Yutaka ; Rosenberg Steven A., Melanoma antigens and their use in diagnostic and therapeutic methods.
  30. Patard Jean-Jacques (Brussels BEX) Brasseur Francis (Brussels BEX) Boon-Falleur Thierry (Brussels BEX), Method for determining bladder tumors by assaying for MAGE-1,2,3 or 4.
  31. Gaugler Batrice (Brussels BEX) Boon-Falleur Thierry (Brussels BEX) van den Eynde Benoit (Brussels BEX) DePlaen Etienne (Brussels BEX) Basseur Francis (Brussels BEX) Lethe Bernard (Brussels BEX) van d, Method for determining head and neck squamous cell carcinomas, prostate carcinomas, and bladder tumors by assaying for m.
  32. Boon-Falleur Thierry,BEX ; Weynants Patrick,BEX ; Lethe Bernard,BEX ; Brasseur Francis,BEX ; Marchand Marie,BEX ; DeSmet Charles,BEX ; Lurquin Christophe,BEX ; van der Bruggen Pierre,BEX ; DePlaen Et, Method for determining lung adenocarcinomas by assaying for one or more of MAGE-1, MAGE-2 and MAGE-3.
  33. Boon-Falleur Thierry,BEX ; Weynants P.,BEX ; Lethe Bernard,BEX ; Brasseur Francis,BEX ; Marchand M.,BEX ; DeSmet Charles,BEX ; Lurquin Christophe,BEX ; Van Der Bruggen Pierre,BEX ; DePlaen Etienne,BE, Method for determining lung adenocarcinomas by assaying for one or more of MAGE-1, MAGE-2 and MAGE-3 gene products.
  34. Van Baren Nicolas,BEX ; Brasseur Francis,BEX ; Boon-Falleur Thierry,BEX, Method for determining multiple myeloma by assaying for expression of mage genes.
  35. Van den Eynde Benoit (Brussels BEX) Boon-Falleur Thierry (Brussels BEX), Method for diagnosing a disorder by determining expression of gage tumor rejection antigen precursors.
  36. Pfreundschuh Michael,DEX, Method for diagnosing cancer via DNA hybridization.
  37. Tureci Ozlem,DEX ; Sahin Ugur,DEX ; Pfreundschuh Michael,DEX, Method for diagnosis and treating cancers, and methods for identifying pathogenic markers in a sample of normal cells.
  38. Boon-Falleur Thierry,BEX ; Brichard Vincent,BEX ; Van Pel Aline,BEX ; De Plaen Etienne,BEX ; Coulie Pierre,BEX ; Renauld Jean-Christope,BEX ; Wolfel Thomas,DEX, Method for identifying individuals suffering from a cellular abnormality some of whose abnormal cells present complexes.
  39. Coulie Pierre,BEX ; Ikeda Hideyuki,BEX ; Boon-Falleur Thierry,BEX, Method for screening for possible presence of cancer.
  40. Simard, John J. L.; Diamond, David C., Method of epitope discovery.
  41. K?ndig, Thomas M.; Simard, John J. L., Method of inducing a CTL response.
  42. Kundig,Thomas M.; Simard,John L., Method of inducing a CTL response.
  43. K��ndig,Thomas M.; Simard,John J. L., Method of inducing a CTL response.
  44. Carson Dennis A. (Del Mar CA) Raz Eyal (San Diego CA), Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleoti.
  45. Sahin Ugur,DEX ; Tureci Ozlem,DEX ; Chen Yao-Tseng ; Old Lloyd J. ; Pfreundschuh Michael,DEX, Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith.
  46. Ugur Sahin DE; 0zlem Tureci DE; Yao-Tseng Chen ; Lloyd J. Old ; Michael Pfreundschuh DE, Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith.
  47. Brichard Vincent,BEX ; Van Pel Aline,BEX ; Traversari Catia,ITX ; Wolfel Thomas,DEX ; Boon-Falleur Thierry,BEX ; De Plaen Etienne,BEX, Methods for determining disorders by assaying for a non-tyrosinase, tumor rejection antigen precursor.
  48. Tureci Ozlem,DEX ; Chen Yao-Tseng ; Sahin Ugur,DEX ; Gure Ali O. ; Old Lloyd J. ; Pfreundschuh Michael,DEX, Methods for determining presence of cancer in a sample by determining expression of an SSX gene.
  49. Pfreundschuh Michael,DEX, Methods for screening for possibility or melanoma in a subject.
  50. Valmori, Danila; Cerottini, Jean-Charles; Romero, Pedro, NY-ESO-1 peptide derivatives, and uses thereof.
  51. Danila Valmori CH; Jean-Charles Cerrotini CH; Pedro Romero CH, NY-ESO-1-peptide derivatives, and uses thereof.
  52. Murphy Gerald P. ; Boynton Alton L. ; Holmes Eric H. ; Barren ; III Robert J., Non-invasive methods to detect prostate cancer.
  53. Liu,Liping; Bot,Adrian; Diamond,David C., PRAME peptide analogues.
  54. Liu,Liping; Bot,Adrian; Gong,Jian; Diamond,David, PSMA peptide analogues.
  55. Slingluff, Craig L.; Engelhard, Victor M.; Hunt, Donald F.; Shabanowitz, Jeffrey; Cox, Andrea L., Peptides recognized by melanoma-specific cytotoxic lymphocytes, and uses therefor.
  56. Israeli Ron S (Forest Hills NY) Heston Warren D. W. (New York NY) Fair William R. (New York NY), Prostate-specific membrane antigen.
  57. Jackson, David Charles; Ghosh, Souravi; Walker, John, T helper cell epitopes.
  58. van der Bruggen Pierre (Brussels BEX) Boon-Falleur Thierry (Brussels BEX), Tumor rejection antigens which correspond to amino acid sequences in tumor rejection antigen precursor bage, and uses th.
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