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Triphosphate oligonucleotide modification reagents and uses thereof 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/00
출원번호 US-0638062 (2006-12-11)
등록번호 US7999098 (2011-08-03)
발명자 / 주소
  • Schwartz, David A.
  • Hogrefe, Richard I.
출원인 / 주소
  • Solulink Biosciences, Inc.
대리인 / 주소
    Jones, Day
인용정보 피인용 횟수 : 0  인용 특허 : 83

초록

Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain

대표청구항

What is claimed is: 1. A compound that has formula (I):P1—S1—B1-M-X

이 특허에 인용된 특허 (83)

  1. Hobbs ; Jr. Frank W. (Wilmington DE) Trainor George L. (Wilmington DE), Alkynylamino-nucleotides.
  2. Schwartz David Aaron ; Daily William J. ; Dwyer Brian Patrick ; Srinivasan Kumar ; Brown Bob Dale, Amide-based cationic lipids.
  3. Schwartz David Aaron ; Dwyer Brian Patrick ; Daily William J. ; Srinivasan Kumar ; Brown Bob Dale, Amide-based oligomeric cationic lipids.
  4. Merrifield D. Bruce (Williamsville NY) Pawlak Joseph A. (Cheektowaga NY) Colson James G. (Williamsville NY), Amine phosphite antioxidants.
  5. Berninger Ronald W. ; Lodge Mark S. ; Tarnowski ; Jr. Stanley Joseph ; Colvin Floyd Warren ; Brinkley John Michael, Aminooxy-containing linker compounds for formation of stably-linked conjugates and methods related thereto.
  6. Masuda Nobuhito (Minami-ashigara JPX) Nagatomo Shigeru (Minami-ashigara JPX) Mihara Yuji (Minami-ashigara JPX), Analysis element for immunochemical measurement of trace components and method for immunochemical measurement using the.
  7. Fodor Stephen P.A. ; Stryer Lubert ; Read J. Leighton ; Pirrung Michael C., Arrays of materials attached to a substrate.
  8. Fox Adrian S. (Waterford CT), Biocompatible poly-(ether-urethane-urea) and process for its preparation.
  9. Braatz James A. (Beltsville MD) Heifetz Aaron H. (Columbia MD), Biocompatible, low protein adsorption affinity matrix.
  10. Schwartz David A. (Exton PA) Abrams Michael J. (Glenmore PA) Giadomenico Christen M. (Exton PA) Zubieta Jon A. (Albany NY), Certain pyridyl hydrazines and hydrazides useful for protein labeling.
  11. Murrer Barry A,GBX ; Schwartz David A, Chemical compounds.
  12. Arnold ; Jr. Lyle John ; Reynolds Mark Alan ; Riley Timothy Andrew ; Schwartz David Aaron ; Vaghefi Morteza Monir, Chirally enriched synthetic phosphate oligomers.
  13. Arnold ; Jr. Lyle J. ; Reynolds Mark A. ; Riley Timothy A. ; Schwartz David A., Chirally enriched synthetic phosphonate oligomers.
  14. Mihara Yuji (Minami-ashigara JPX) Masuda Nobuhito (Minami-ashigara JPX) Hiratsuka Nobuo (Tokyo JPX) Miyazako Takushi ; both of (Tokyo JPX) Ikeda Tadashi (Minami-ashigara JPX), Competitive immunoassay using spectral sensitizer label.
  15. Musso Gary F. (San Diego CA) Ghosh Soumitra (San Diego CA) Orgel Leslie E. (La Jolla CA) Wahl Geoffrey M. (San Diego CA) Kaiser Emil T. (New York NY), Compounds for tagging nucleic acid probes.
  16. Tsibris John C. M. (Gainesville FL), Copolymers of (a) aminimides and (b) vinyl pendant primary halomethy monomers useful for affinity chromatography.
  17. Anderson Stephen ; Rogers Yu-Hui, Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds.
  18. Waggoner Alan S. (Pittsburgh PA), Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods.
  19. Koster Hubert (Concord MA), DNA sequencing by mass spectrometry.
  20. Koster Hubert, DNA sequencing by mass spectrometry via exonuclease degradation.
  21. Schwartz David Aaron ; Dwyer Brian Patrick ; Daily William J. ; Srinivasan Kumar ; Brown Bob Dale, Dimeric cationic lipids.
  22. Reusser Robert E. (Bartlesville OK) Hughes William B. (Bartlesville OK), Disproportionation/double-bond isomerization of olefins.
  23. Ghosh Soumitra S. (San Diego CA) Fahy Eoin D. (La Jolla CA), End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids.
  24. Ghosh Soumitra S. (San Diego CA) Fahy Eoin D. (San Diego CA), End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids.
  25. Ghosh Soumitra Shanker (San Diego CA) Fahy Eoin D. (San Diego CA), End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids.
  26. Parandoosh Zahra, Fluorescence-based assays for measuring cell proliferation.
  27. Musso Gary F. (San Diego CA) Ghosh Soumitra (San Diego CA) Orgel Leslie E. (La Jolla CA) Wahl Geoffrey M. (San Diego CA) Kaiser Emil T. (New York NY), Fluorescent compounds for tagging nucleic acid probes.
  28. Rabbani Elazar (New York NY), Heterologous system for the detection of chemically labeled DNA and other biological materials providing a receptor or t.
  29. Ayers John S. (Heslington GB2), Hydroxyalkylated cross-linked regenerated cellulose and method of preparation thereof.
  30. Pidgeon Charles (West Lafayette IN), Immobilized artificial membranes.
  31. Desai Neil P. (Los Angeles CA) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Heintz Roswitha E. (Los Angeles CA), Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods.
  32. Matthews Virgil Edison (Charleston WV) Knopf Robert John (Saint Albans WV), Lightly cross-linked polyurethane hydrogels based on poly(alkylene ether) polyols.
  33. Velander William H. (Blacksburg VA) Kaster Jeffrey A. (Blacksburg VA) Glasser Wolfgang G. (Blacksburg VA), Lignocellulosic and cellulosic beads for use in affinity and immunoaffinity chromatography of high molecular weight prot.
  34. Nova Michael P. ; Parandoosh Zahra ; Senyei Andrew E. ; Xiao Xiao-Yi ; David Gary S. ; Satoda Yozo ; Zhao Chanfeng ; Potash Hanan, Matrices with memories and uses thereof.
  35. Nova Michael P. ; Parandoosh Zahra ; Senyei Andrew E. ; Xiao Xiao-Yi ; David Gary S. ; Satoda Yozo ; Zhao Chanfeng ; Potash Hanan, Matrices with memories and uses thereof.
  36. Masuda Nobuhito (Minami-ashigara JPX) Nagatomo Shigeru (Minami-ashigara JPX) Mihara Yuji (Minami-ashigara JPX), Method for immunochemical measurement of trace components.
  37. Waggoner Alan S. (Pittsburgh PA) Ernst Lauren A. (Pittsburgh PA) Mujumdar Ratnakar B. (Glenshaw PA), Method for labeling and detecting materials employing arylsulfonate cyanine dyes.
  38. Waggoner Alan S. (Pittsburgh PA) Ernst Lauren A. (Pittsburgh PA) Mujumdar Ratnakar B. (Glenshaw PA), Method for labeling and detecting materials employing arylsulfonate cyanine dyes.
  39. Waggoner Alan S. (Pittsburgh PA), Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes.
  40. Pidgeon Charles (West Lafayette IN), Method for solid phase membrane mimetics.
  41. Biebricher Christof (Adelebsen DEX) Luce Rudiger (Herzberg DEX), Method for the production of a vehicle substance which is capable of covalent bonding with biologically active matter.
  42. Prober James M. (Wilmington DE) Dam Rudy J. (Landenberg PA) Robertson ; Jr Charles W. (Rockland DE) Hobbs ; Jr. Frank W. (Wilmington DE) Trainor George L. (Glen Mills PA), Method, system and reagents for DNA sequencing.
  43. Cargill John ; Armstrong Robert W., Methods and apparatus for synthesizing labeled combinatorial chemistry libraries.
  44. Daily William J. ; Schwartz David Aaron, Methylphosphonate dimer synthesis.
  45. Jones David S. ; Hachmann John P. ; Conrad Michael J. ; Coutts Stephen ; Livingston Douglas Alan, Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides.
  46. Jones David S. ; Hachmann John P. ; Conrad Michael J. ; Coutts Stephen ; Livingston Douglas Alan, Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides.
  47. Abrams Michael J. (Glenmore PA) Bridger Gary J. (West Chester PA) Schwartz David A. (Encinitas CA) Padmanabhan Sreenivasan (Exton PA) Ultee Michael E. (Belle Mead NJ), Molecule labelling using 2-hydraninopyridine derivatives.
  48. Wohlstadter Jacob N. ; Wilbur James ; Sigal George ; Martin Mark ; Guo Liang-Hong ; Fischer Alan ; LeLand Jon, Multi-array, multi-specific electrochemiluminescence testing.
  49. Ishii Jennifer K. (San Diego CA) Ghosh Soumitra (San Diego CA), Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions.
  50. Stavrianopoulos Jannis G. (New York NY), Nucleic acid hybridization assay and detectable molecules useful in such assay.
  51. Meade Thomas J. ; Kayyem Jon Faiz ; Fraser Scott E., Nucleic acid mediated electron transfer.
  52. Meade Thomas J. ; Kayyem Jon Faiz ; Fraser Scott E., Nucleic acid mediated electron transfer.
  53. Meade Thomas J. ; Kayyem Jon Faiz ; Fraser Scott E., Nucleic acid mediated electron transfer.
  54. Arnold ; Jr. Lyle J. ; Reynolds Mark A. ; Schwartz David A. ; Daily William J., Oligonucleoside cleavage compounds and therapies.
  55. Dower William J. (Menlo Park CA) Cwirla Steven E. (Palo Alto CA) Barrett Ronald W. (Sunnyvale CA), Peptide library and screening systems.
  56. Tam James P. (New York NY) Heath ; Jr. William F. (New York NY) Merrifield Robert B. (Cresskill NJ), Peptide synthesis reagents and method of use.
  57. Dwyer Brian Patrick ; Lehedev Alexandre V. ; Brown Bob Dale ; Schwartz David Aaron, Phosphonic acid-based cationic lipids.
  58. Wood Louis L. (Rockville MD), Plant growth media utilizing polyurethane hydrogel.
  59. Hensel Hartmut (Klagenfurth ATX) Dinter Peter (Oestrich-Winkel DEX) Grosse-Kreul Theo (Wiesbaden DEX) Gribbin John D. (Schlangenbad DEX), Polyester film having improved adhesion properties.
  60. Crane Laura J. (Buttzville NJ) Kakodkar Sunil V. (Bethlehem PA), Polyethyleneimine matrixes for affinity chromatography.
  61. Gould Francis E. (Princeton NJ) Johnston Christian W. (Neshanic Station NJ), Polyurethane diacrylate compositions as carrier for pharmacological agents.
  62. Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
  63. Schwartz David A. ; Abrams Michael J. ; Giandomenico Christen M. ; Zubieta Jon A., Protein labelling.
  64. Schwartz David A. ; Abrams Michael J. ; Giandomenico Christen M. ; Zubieta Jon A., Protein labelling.
  65. Schwartz David A. (Exton PA) Abrams Michael J. (Glenmore PA) Giandomenico Christen M. (Exton PA) Zubieta Jon A. (Albany NY), Protein labelling utilizing certain pyridyl hydrazines, hydrazides and derivatives.
  66. O\Shannessy Daniel J. (256 Congressional La. #T3 Rockville MD 20852), Proteins bound to a marker or solid phase support matrix using a hydrazone linkage.
  67. Nova Michael P. ; Senyei Andrew E., Remotely programmable matrices with memories.
  68. Nova Michael P. ; Senyei Andrew E., Remotely programmable matrices with memories.
  69. Nova Michael P. ; Senyei Andrew E., Remotely programmable matrices with memories.
  70. Nova Michael P. ; Senyei Andrew E. ; David Gary S., Remotely programmable matrices with memories.
  71. Nova Michael P. ; Senyei Andrew E. ; Parandoosh Zahra ; David Gary S., Remotely programmable matrices with memories and uses thereof.
  72. Berninger Ronald W. ; Lodge Mark S. ; Tarnowski ; Jr. Stanley Joseph, Semicarbazide-containing linker compounds for formation of stably-linked conjugates and methods related thereto.
  73. Dower William J. (Menlo Park CA) Fodor Stephen P. A. (Palo Alto CA), Sequencing of surface immobilized polymers utilizing microflourescence detection.
  74. Wenzel Wolfgang (Bergisch-Gladbach DEX) Dieterich Dieter (Leverkusen DEX), Solid, water-dispersible plastics precursors containing isocyanate groups, a process for the production of aqueous plast.
  75. Coupek Jiri (Prague CSX) Turkova Jaroslava (Cesky Brod CSX) Blaha Karel (Prague CSX) Valentova Olga (Prague CSX), Specific sorbent having D-aminoacid moiety covalently bonded to solid particulate hydrophilic polymeric carrier.
  76. Afeyan Noubar B. (Brookline MA) Hodjat Hossein K. (Jamaica Plain MA) Varady Laszlo (Malden MA), Sulfonamide bonded hydrophilic coatings.
  77. Musso Gary F. (San Diego CA) Ghosh Soumitra (San Diego CA) Kaiser Emil T. (New York NY), Sulfonamide-derivative compounds for tagging nucleic acid probes.
  78. Ayers John S. (Palmerston North NZX) Husbands David R. (Palmerston North NZX), Sulphated ion exchanger and method for preparation thereof.
  79. Lockhart David J. (Santa Clara CA) Vetter Dirk (Freiburg DEX) Diggelmann Martin (Niederdorf CHX), Surface-bound, unimolecular, double-stranded DNA.
  80. Arnold ; Jr. Lyle J. ; Hogrefe Richard I. ; Reynolds Mark A. ; Riley Timothy A. ; Schwartz David A., Synthetic oligomers having chirally pure phoshonate internucleosidyl linkages mixed with non-phosphonate internucleosidy.
  81. Arnold ; Jr. Lyle John ; Hogrefe Richard Isais ; Reynolds Mark Alan ; Riley Timothy Andrew ; Schwartz David Aaron ; Vaghefi Morteza Monir ; Brown Bob Dale, Synthetic oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages.
  82. Sivam Gowsala P. (Edmonds WA) Morgan ; Jr. A. Charles (Edmonds WA) Vrudhula Vivekananda M. (Edmonds WA), Targeting substance-diagnostic/therapeutic agent conjugates having schiff base linkages and methods for their preparatio.
  83. Stolowitz Mark L. ; Kaiser Robert J., Use of boron-containing polynucleotides as diagnostic agents.
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