초록 ▼

The invention relates to sutures and surgical staples useful in anastomoses. Various aspects of the invention include wound closure devices that use amphiphilic copolymer or parylene coatings to control the release rate of an agent, such as a drug or a biological material, polymerizing a solution co

The invention relates to sutures and surgical staples useful in anastomoses. Various aspects of the invention include wound closure devices that use amphiphilic copolymer or parylene coatings to control the release rate of an agent, such as a drug or a biological material, polymerizing a solution containing monomers and the agent to form a coating, using multiple cycles of swelling a polymer with a solvent-agent solution to increase loading, microparticles carrying the agent, biodegradable surgical articles with amphiphilic copolymer coatings, and sutures or surgical staples the deliver a drug selected from the group consisting of triazolopyrimidine, paclitaxol, sirolimus, derivatives thereof, and analogs thereof to a wound site.

대표청구항 ▼

The invention claimed is: 1. A surgical article, comprising:a surgical joining device selected from the group consisting of sutures and surgical staples said surgical joining device formed of a biostable or bioabsorbable polymer;a coating over a surface of said device, said coating including amphiph

The invention claimed is: 1. A surgical article, comprising:a surgical joining device selected from the group consisting of sutures and surgical staples said surgical joining device formed of a biostable or bioabsorbable polymer;a coating over a surface of said device, said coating including amphiphilic copolymer; andan agent carried by said coating or said device such that said coating controls a release rate of said agent;wherein said agent present in a functional amount with a function selected from the group consisting of preventing scarring, preventing infection, or preventing an adverse reaction to a procedure for installing said device; andsaid amphiphilic copolymer comprising a network including both hydrophobic and hydrophilic polymer chains that are able to swell in both hydrophobic and hydrophilic solvents, said hydrophobic polymer chain including polyolefin or polysiloxane, said hydrophilic polymer chain including poly(alkylene glycol), polyacrylate, or aminoalkyl acrylate, said network including PEG, PIB, PDMS, and combinations thereof.