초록 ▼

The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the directio

The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.

대표청구항 ▼

We claim: 1. An ocular controlled release bioactive agent delivery device comprising:a. a coil-shaped body member formed of a material that has a cross-section of 1 mm or less and does not include a lumen, the body member having a direction of extension, a longitudinal axis along the direction of ex

We claim: 1. An ocular controlled release bioactive agent delivery device comprising:a. a coil-shaped body member formed of a material that has a cross-section of 1 mm or less and does not include a lumen, the body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension;b. a polymeric coated composition in contact with at least a portion of the body member, the polymeric coated composition comprising a first polymer, a second polymer, and a bioactive agent,wherein the first polymer comprises polyalkyl(meth)acrylate, andwherein the second polymer comprises poly(ethylene-co-vinyl acetate); andc. a cap positioned at the proximal end of the body member,wherein the body member has a length from its proximal end to its distal end of 1 cm or less, and the cap has a thickness that is 10% or less of the length of the body member, andwherein the bioactive agent is present in an amount in the range of 1 μg to 10 mg of bioactive agent per cm2 of the coated surface of the device.