초록 ▼

A porous composite comprising a porous layer containing a calcium phosphate ceramic, and a dense layer formed on part of the porous layer and having a smaller average pore size than that of the porous layer. The porous composite can be produced by (1) introducing a slurry containing a calcium phosph

A porous composite comprising a porous layer containing a calcium phosphate ceramic, and a dense layer formed on part of the porous layer and having a smaller average pore size than that of the porous layer. The porous composite can be produced by (1) introducing a slurry containing a calcium phosphate ceramic/collagen composite and collagen into a molding die having a high thermal conductivity, (2) rapidly freezing and drying the slurry in the molding die, to form a porous body comprising a porous layer and a dense layer formed on the porous layer, (3) cross-linking collagen in the porous body, and (4) removing the dense layer except for a portion thereof on a surface coming into contact with a soft tissue when implanted in a human body, so that the porous layer is exposed.

대표청구항 ▼

What is claimed is: 1. A porous composite comprising a porous layer, and a dense layer formed on part of said porous layer and having a smaller average pore size or porosity than that of said porous layer, wherein said dense layer comprises a flange extending from a surface of the porous layer, and

What is claimed is: 1. A porous composite comprising a porous layer, and a dense layer formed on part of said porous layer and having a smaller average pore size or porosity than that of said porous layer, wherein said dense layer comprises a flange extending from a surface of the porous layer, and said flange and said porous layer are integral and of one-piece construction, and wherein said porous layer and said dense layer consist essentially of a hydroxyapatite/collagen composite and a collagen binder, and said porous layer has a porosity of 90-98%.