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B7-DC variants 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-014/00
출원번호 US-0932471 (2007-10-31)
발명자 / 주소
  • Chen, Lieping
출원인 / 주소
  • Mayo Foundation for Medical Education and Research
대리인 / 주소
    Fish & Richardson P.C.
인용정보 피인용 횟수 : 10  인용 특허 : 54

초록

Variant costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein.

대표청구항 ▼

What is claimed is: 1. An isolated variant B7-DC polypeptide comprising an IgV domain, wherein the variant polypeptide is a variant of wild-type B7-DC polypeptide, has altered binding affinity for PD-1 compared to the wild-type B7-DC polypeptide, and comprises a substitution of an amino acid in the

이 특허에 인용된 특허 (54)

  1. Mikesell, Glen E; Chang, Han; Peach, Robert J., Antibodies directed to B7-related polypeptide, BSL-2.
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  2. Freeman Gordon J. ; Nadler Lee M. ; Gray Gary S., B7-2: a CTLA4/CD28 ligand.
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  3. Pardoll,Drew M.; Tsuchiya,Haruo; Gorski,Kevin S.; Tseng,Su Yi, B7-DC, Dendritic cell co-stimulatory molecules.
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  4. Chen,Lieping, B7-H1 variants.
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  5. Coyle, Anthony J.; Fraser, Christopher C.; Manning, Stephen, B7-H2 Polypeptides.
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  6. Coyle, Anthony J.; Fraser, Christopher C.; Manning, Stephen, B7-H2 nucleic acids, members of the B7 family.
    상세보기
  7. Mikesell, Glen Eugene; Chang, Han; Finger, Joshua N.; Yang, Guchen; Peach, Robert James; Shen, Henry, BSL3 polypeptides.
    상세보기
  8. Sledziewski Andrzej Z. ; Bell Lillian Anne ; Kindsvogel Wayne R., Biologically active dimerized and multimerized polypeptide fusions.
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  9. Linsley Peter S. (Seattle WA) Ledbetter Jeffrey A. (Seattle WA) Damle Nitin K. (Renton WA) Brady William (Bothell WA), CD28IG fusion protein.
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  10. Sledziewski Andrzej Z. ; Bell Lillian Anne ; Kindsvogel Wayne R., DNA constructs encoding ligand-binding fusion proteins.
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  11. Miller A. Dusty (Seattle WA), DNA constructs for retrovirus packaging cell lines.
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  12. Steiner Solomon (Mt. Kisco NY) Rosen Robert (Rochester NY), Delivery systems for pharmacological agents encapsulated with proteinoids.
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  13. Moore,Margaret D.; Fox,Brian A., Dimeric fusion proteins and materials and methods for producing them.
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  14. Moore,Margaret Dow; Fox,Brian A., Dimerized PDGF-D and materials and methods for producing it.
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  15. Sledziewski Andrzej Z. ; Bell Lillian Anne ; Kindsvogel Wayne R., Dimerized polypeptide fusions.
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  16. Collins Francis S. (Ann Arbor MI) Wilson James M. (Ann Arbor MI), Gene therapy vector for cystic fibrosis.
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  18. Rosen,Craig A.; Ruben,Steven M., Human secreted proteins.
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  19. Capon Daniel J. ; Lasky Laurence A., Hybrid immunoglobulins.
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  20. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
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  21. Kappel Thomas F. (St. Louis MO), Inflatable blanket having perforations of different sizes.
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  22. Sledziewski Andrzej Z. ; Bell Lillian Anne ; Kindsvogel Wayne R., Ligand-binding, dimerized polypeptide fusions.
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  23. Woodle Martin C. (Menlo Park CA) Martin Francis J. (San Francisco CA) Yau-Young Annie (Los Altos CA) Redemann Carl T. (Walnut Creek CA), Liposomes with enhanced circulation time.
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  24. Capon Daniel J. (San Mateo CA) Lasky Laurence A. (Sausalito CA), Lymphocyte homing receptor/immunoglobulin fusion proteins.
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  25. Honjo, Tasuku; Minato, Nagahiro; Iwai, Yoshiko; Shibayama, Shiro, Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1.
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  26. Sledziewski Andrzej Z. (Seattle WA) Bell Lillian A. (Seattle WA) Kindsvogel Wayne R. (Seattle WA), Method of producing secreted receptor analogs and biologically active peptide dimers.
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  27. Carreno,Beatriz M.; Leonard,John, Methods for downmodulating immune cells using an antibody to PD-1.
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  28. Sledziewski Andrzej Z. ; Bell Lillian Anne ; Kindsvogel Wayne R., Methods for producing secreted ligand-binding fusion proteins.
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  29. Freeman, Gordon J.; Chernova, Irene; Chernova, Tatyana; Malenkovich, Nelly; Wood, Clive R., Methods for upregulating an immune response with agents that inhibit the intereaction between PD-L2 and PD-1.
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  30. Freeman,Gordon; Chernova,Irene; Chernova,Tatyana; Malenkovich,Nelly; Wood,Clive; Latchman,Yvette; Sharpe,Arlene H., Methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1 mediated signal.
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  31. Sledziewski Andrzej Z. ; Bell Lillian Anne ; Kindsvogel Wayne R., Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions.
    상세보기
  32. Sledziewski Andrzej Z. ; Bell Lillian Anne ; Kindsvogel Wayne R., Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions.
    상세보기
  33. Sledziewski Andrzej Z. (Seattle WA) Bell Lillian A. (Seattle WA) Kindsvogel Wayne R. (Seattle WA), Methods of using biologically active dimerized polypeptide fusions to detect PDGF.
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  34. Jaffe Howard (Gaithersburg MD), Microencapsulation process.
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  35. Paoletti Enzo (Delmar NY) Panicali Dennis (Averill Park NY), Modified vaccinia virus and methods for making and using the same.
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  36. Pardoll, Drew M.; Tsuchiya, Haruo; Gorski, Kevin S.; Tseng, Su Yi, Nucleic acid encoding dendritic cell co-stimulatory molecules.
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  37. Tang, Y. Tom; Goodrich, Ryle; Liu, Chenghua; Ren, Feiyan; Wang, Dunrui; Drmanac, Radoje T., Nucleic acids and polypeptides.
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  38. Tang, Y. Tom; Zhou, Ping; Goodrich, Ryle; Liu, Chenghua; Asundi, Vinod; Ren, Feiyan; Zhang, Jie; Zhao, Qing A.; Yang, Yonghong; Xue, Aidong J.; Wehrman, Tom; Wang, Jian-Rui; Wang, Dunrui; Drmanac, Ra, Nucleic acids and polypeptides.
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  39. Fox,Gary M.; Sullivan,John K; Holst,Paige; Yoshinaga,Steven Kiyoshi, Nucleic acids encoding B7-Like molecules and uses thereof.
    상세보기
  40. Mikesell,Glen Eugene; Chang,Han; Peach,Robert James, Polynucleotides encoding BSL3.
    상세보기
  41. Mikesell,Glen Eugene; Chang,Han; Peach,Robert James, Polynucleotides-encoding B7-related polypeptide, BSL2-L165-35B.
    상세보기
  42. Mathiowitz Edith (Brookline MA) Langer Robert S. (Somerville MA), Preparation of multiwall polymeric microcapsules.
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  43. Temin Howard M. (Madison WI) Dougherty Joseph P. (Madison WI), Promoter deficient retroviral vector.
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  44. Platz Robert M. (Half Moon Bay CA) Winters Mark A. (Mountain View CA) Pitt Colin G. (Thousand Oaks CA), Pulmonary administration of granulocyte colony stimulating factor.
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  45. Wong Jeffrey T.-F. (Hong Kong HKX) Tam Michael S.-C. (Shatin HKX), Pulmonary drug delivery system.
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  46. Paoletti Enzo (Albany NY), Recombinant poxvirus host range selection system.
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  47. Paoletti Enzo (Albany NY), Recombinant poxvirus host range selection system.
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  48. Paoletti Enzo (Albany NY), Recombinant poxvirus internal cores.
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  49. Temin Howard M. (Madison WI) Dougherty Joseph P. (Madison WI), Recombination resistant retroviral helper cell and products produced thereby.
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  50. Bank Arthur (Riverdale NY) Markowitz Dina G. (New York NY) Goff Stephen P. (Tenafly NJ), Retroviral packaging cell lines and process of using same.
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  51. Wills John W. (Shreveport LA), Retrovirus-mediated secretion of recombinant products.
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  52. Coyle,Anthony J.; Fraser,Christopher C.; Manning,Stephen, Screening methods using B7-H2 molecules, members of the B7 family.
    상세보기
  53. Honjo, Tasuku; Shibayama, Shiro; Takeda, Kazuhiko; Matsuo, Masayoshi; Yoshida, Takao; Miyamoto, Masakazu, Substance specific to human PD-1.
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  54. Freeman Gordon J. ; Nadler Lee M. ; Gray Gary S., Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor.
    상세보기

이 특허를 인용한 특허 (10)

  1. Chen, Lieping, B7-DC variants immunogenic compositions and methods of use thereof.
    상세보기
  2. Chen, Lieping, B7-DC variants immunogenic compositions and methods of use thereof.
    상세보기
  3. Chen, Lieping; Strome, Scott E.; Kwon, Eugene D., B7-H1 and methods of diagnosis, prognosis, and treatment of cancer.
    상세보기
  4. Chen, Lieping, B7-H1 antibodies and method of use.
    상세보기
  5. Langermann, Solomon; Liu, Linda, Compositions of PD-1 antagonists and methods of use.
    상세보기
  6. Chen, Lieping; Strome, Scott E.; Kwon, Eugene D., Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target.
    상세보기
  7. Pardoll, Drew M.; Tsuchiya, Haruo; Gorski, Kevin S.; Tseng, Su-Yi, Dendritic cell co-stimulatory molecules.
    상세보기
  8. Dong, Haidong; Kwon, Eugene D.; Markovic, Svetomir N.; Krco, Christopher J., Methods and materials for treating cancer.
    상세보기
  9. Dong, Haidong; Harrington, Susan M.; Kwon, Eugene D.; Krco, Christopher J.; Liu, Xin, Methods for treating cancer in patients with elevated levels of BIM.
    상세보기
  10. Chen, Lieping, Nucleic acid molecules encoding B7-DC variants.
    상세보기

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