초록 ▼

Crosslinkable compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the c

Crosslinkable compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. In one embodiment, a first component has nucleophilic groups and a second component has electrophilic groups. Additional components may have nucleophilic or electrophilic groups. Methods for preparing and using the compositions are also provided as are kits for delivery of the compositions. Exemplary uses for the crosslinked compositions include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.

대표청구항 ▼

We claim: 1. A kit for forming cross-linked biomaterials for medical applications, comprising:(a) a dry powder composition comprising pentaerythritol tetrakis [1-(1′-oxo-5-succimidylpentanoate)-2-poly(oxyethylene) ether and pentaerythritol tetrakis [mercaptoethyl poly(oxyethylene) ether;(b) a first

We claim: 1. A kit for forming cross-linked biomaterials for medical applications, comprising:(a) a dry powder composition comprising pentaerythritol tetrakis [1-(1′-oxo-5-succimidylpentanoate)-2-poly(oxyethylene) ether and pentaerythritol tetrakis [mercaptoethyl poly(oxyethylene) ether;(b) a first solution having a pH of 2.1-2.3; and(c) a second solution having a pH of 9.6, 9.65-9.75, 9.7, or 10, wherein each of (a), (b) and (c) is packaged separately prior to use.