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특허 상세정보

MyON담기
내보내기 페이스북 공유 카카오톡 공유

Method for treatment of constipation-predominant irritable bowel syndrome

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-036/00   
미국특허분류(USC) 424/725
출원번호 US-0476590 (2009-06-02)
등록번호 US8067041 (2011-11-16)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    McCarter & English, LLP
인용정보 피인용 횟수 : 32  인용 특허 : 9
초록
▼

The present invention provides methods for treating constipation-predominant irritable bowel syndrome comprising administering to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat constipation-predominant irritable bowel syndrome (c-IBS). Treatment of c-IBS includes the treatment of the constipation component of c-IBS as well as the pain and abdominal discomfort associated with c-IBS. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. Th...

대표
청구항

What is claimed is: 1. A method of treating constipation-predominant irritable bowel syndrome (c-IBS), comprising administering to a patient in need of such treatment, an amount of an extract isolated from the latex of a Croton spp. or Calophyllum spp. effective to treat c-IBS, wherein said amount is bioequivalent to an orally administered dose of about 250 mg per day to about 4000 mg per day of crofelemer.

이 특허에 인용된 특허 (9)

  1. Schultz Bruce D. Diarylsulfonylureas for use in treating secretory diarrhea. USP2001086281240.
  2. Virdalm Carl A. (Starevagen 10 872 00 Kramfors SEX). Method for suppressing states of illness in the digestive system. USP1989084857327.
  3. Bobrowski,Paul J.. Methods and preparations of the latex from the croton species. USP2007047208183.
  4. Tempesta Michael S. (Moss Beach CA). Methods for using proanthocyanidin polymers having antiviral activity. USP1996025494661.
  5. Verkman,Alan; Ma,Tonghui. Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors. USP2007067235573.
  6. Masquelier Jack (Parc des Tourelles FRX). Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof. USP1987104698360.
  7. Tempesta Michael S. (Moss Beach CA). Proanthocyanidin polymers having antiviral activity and methods of obtaining same. USP1993055211944.
  8. Wrsch Pierre (La Tour-De-Peil CHX). Treatment of diarrhoea with compositions derived from carob pod. USP1991085043160.
  9. Welsh Michael J. (Riverside IA) Sheppard David N. (Coralville IA). Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea. USP1993085234922.

이 특허를 인용한 특허 피인용횟수: 32

  1. Huang, Alexander L.; Wu, Gin. Antibacterial having an extract of pomegranate combined with hydrogen peroxide. USP2014058734867.
  2. Quart, Barry D.. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer. USP2018069987250.
  3. Quart, Barry D.. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer. USP2014108852649.
  4. Quart, Barry D.; Rosenbaum, David P.. Method for treatment of constipation-predominant irritable bowel syndrome. USP2015099138450.
  5. Quart, Barry D.; Rosenbaum, David; Neenan, Thomas; Blanks, Robert C.. Method for treatment of diarrhea-predominant irritable bowel syndrome. USP2018059980938.
  6. Huang, Alexander L; Wu, Gin. Method of killing a bacteria with a plant-based biocidal solution. USP2017059636361.
  7. Huang, Alexander L.; Wu, Gin. Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide. USP2015119192635.
  8. Forbes, William; Bortey, Enoch; King, Steven; Chaturvedi, Pravin. Methods and compositions for treating HIV-associated diarrhea. USP2017039585868.
  9. Forbes, William; Bortey, Enoch; King, Steven; Chaturvedi, Pravin. Methods and compositions for treating HIV-associated diarrhea. USP2015028962680.
  10. Huang, Alexander L; Wu, Gin. Methods of inhibiting a bacterial virulence in a subject. USP2017039603883.
  11. Huang, Alexander L; Wu, Gin. Methods of treating a gastrointestinal spasm associated with chemotherapy or radiation therapy. USP2016089408869.
  12. Huang, Alexander L; Wu, Gin. Methods of treating a treatment-resistant gastrointestinal spasm. USP2018039907818.
  13. Huang, Alexander L; Wu, Gin. Methods of treating a treatment-resistant gastrointestinal spasm with an oxidized tannin. USP20180810039784.
  14. Huang, Alexander L; Wu, Gin. Methods of treating drug side-effects that include a gastrointestinal spasm. USP2015079089596.
  15. Huang, Alexander L; Wu, Gin. Methods of treating gastroesophageal reflux disease. USP2017039603871.
  16. Huang, Alexander L; Wu, Gin. Methods of treating gastrointestinal spasms. USP2014058716351.
  17. Huang, Alexander L; Wu, Gin. Methods of treating gastrointestinal spasms in a subject having Crohn's Disease or ulcerative colitis. USP2014058716353.
  18. Huang, Alexander L; Wu, Gin. Methods of treating gastrointestinal spasms in a subject having colorectal cancer. USP2014078772352.
  19. Huang, Alexander L; Wu, Gin. Methods of treating gastrointestinal spasms in a subject having diverticulitis. USP2014078772350.
  20. Huang, Alexander L; Wu, Gin. Methods of treating gastrointestinal spasms triggered by stress. USP2014088809399.
  21. Huang, Alexander L; Wu, Gin. Methods of treating malnutrition. USP2015028946304.
  22. Huang, Alexander L; Wu, Gin. Methods of treating necrotic enteritis. USP2015059023895.
  23. Huang, Alexander L.; Wu, Gin. Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites. USP2014058722040.
  24. Huang, Alexander L; Wu, Gin. Tannin formulation for treating GI spasms. USP2014058716352.
  25. Huang, Alexander L; Wu, Gin. Tannin formulation for treating GI spasms in a subject having Crohn's disease or ulcerative colitis. USP2014078765818.
  26. Huang, Alexander L; Wu, Gin. Tannin formulation for treating gastrointestinal spasms in a subject having colorectal cancer. USP2014098822544.
  27. Huang, Alexander L; Wu, Gin. Tannin formulation for treating gastrointestinal spasms in a subject having diverticulitis. USP2014078772351.
  28. Huang, Alexander L; Wu, Gin. Tannin formulation for treating gastrointestinal spasms triggered by stress. USP2014098822545.
  29. Huang, Alexander L; Wu, Gin. Tannin formulation for treating malnutrition. USP2015028952072.
  30. Huang, Alexander L; Wu, Gin. Therapeutic composition produced using Camellia sinensis leaves and hydrogen peroxide. USP2013118586110.
  31. Huang, Alexander L.; Wu, Gin. Treating a bacteria-induced gastric disorder with a mixture having pomegranate and hydrogen peroxide. USP2014058722116.
  32. Huang, Alexander L; Wu, Gin. Treating inflammation with a binding system. USP2014078790640.

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