초록 ▼

Disclosed is an adhesive hemostatic agent based on non-blood constituents including DOPA, able to strongly adhere to collagen fibers. The agent includes an antifibrinolytic agent in addition to an esterified atelocollagen which is non-immunogenic and may become positively charged thereon such that t

Disclosed is an adhesive hemostatic agent based on non-blood constituents including DOPA, able to strongly adhere to collagen fibers. The agent includes an antifibrinolytic agent in addition to an esterified atelocollagen which is non-immunogenic and may become positively charged thereon such that the adhesive hemostatic agent has no possibility of mediating particular diseases or viral infections (HIV, HCV, HBV, CMV, etc), unlike conventional agents comprising blood constituents, and readily binds to negatively charged platelets at high adhesive strength, thus inducing quick blood coagulation. Also, provided is a method for preparing the same.

대표청구항 ▼

I claim: 1. A method for preparing an esterified atelocollagen for use in a collagen-based adhesive hemostatic agent, comprising:removing immunogenic telo-peptides from porcine collagen through enzyme treatment to afford atelocollagen;reacting an aqueous 0.5-5 wt % solution of the atelocollagen with

I claim: 1. A method for preparing an esterified atelocollagen for use in a collagen-based adhesive hemostatic agent, comprising:removing immunogenic telo-peptides from porcine collagen through enzyme treatment to afford atelocollagen;reacting an aqueous 0.5-5 wt % solution of the atelocollagen with a 65-95 wt % ethanol solution at 4° C. for 24-48 hours with stirring to afford an esterified atelocollagen solution; andadjusting the pH of the esterified atelocollagen solution to 7.4 with 0.1-1 M acetic acid;wherein the method yields an aqueous solution of 0.5-5 wt % esterified atelocollagen having a pH of 7.4 adjusted with 0.1-1 M acetic acid.