초록 ▼

The invention provides a polymeric film-forming medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c)

The invention provides a polymeric film-forming medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of tissue morbidity, d) hemostasis, e) coating and protection of tissue during healing. e) promotion of healing, and f) reduction of pain.

대표청구항 ▼

1. A method of postoperative surgical site treatment for use after removal of the tonsils or adenoids which comprises the step of applying to throat tissue a powder which forms into a medical sealant, the powder comprising chitosan and a crosslinking agent comprising an aldehyde, wherein the sealant

1. A method of postoperative surgical site treatment for use after removal of the tonsils or adenoids which comprises the step of applying to throat tissue a powder which forms into a medical sealant, the powder comprising chitosan and a crosslinking agent comprising an aldehyde, wherein the sealant performs at least one of the following functions: a) inhibits the colonization of bacteria, b) inhibits the binding of bacteria to tissue, c) reduces tissue morbidity, d) hemostasis, e) coats and protects tissue during healing, f) promotes healing, or g) reduces pain. 2. A method according to claim 1 wherein the sealant is a crosslinked synthetic polymer. 3. A method according to claim 1 wherein the sealant is a crosslinked natural polymer. 4. A method according to claim 1 wherein the sealant inhibits the colonization of bacteria. 5. A method according to claim 1 wherein the sealant inhibits the binding of bacteria to tissue. 6. A method according to claim 1 wherein the powder reduces tissue morbidity in tissue to which it is applied. 7. A method according to claim 1 wherein the powder reduces bleeding. 8. A method according to claim 1 wherein the powder coats and protects tissue. 9. A method according to claim 1 wherein the powder promotes healing. 10. A method according to claim 1 wherein the powder reduces pain in tissue to which it is applied. 11. A method according to claim 1 wherein the sealant is a viscoelastic material. 12. A method according to claim 1 wherein the sealant hardens or crosslinks to form a semi-pliable barrier upon application. 13. A method according to claim 1 wherein the sealant has a residence time of at least one day. 14. A method according to claim 1 wherein the sealant has a residence time of at least one week. 15. A method according to claim 1 wherein the sealant has a residence time of at least one month. 16. A method according to claim 1 comprising applying the chitosan and crosslinking agent as an atomized powder mixture. 17. A method according to claim 1 wherein the crosslinking agent comprises formaldehyde. 18. A method according to claim 1 wherein the crosslinking agent comprises glutaraldehyde. 19. A method according to claim 1 wherein the powder includes at least one therapeutic agent selected from the group consisting of analgesics, antihistamines, anti-infective agents, anti-fungal agents, biostatic compositions, anti-inflammatory agents, anti-cholinergics, anti-neoplastic agents, cytokines, decongestants, vitamins, peptides, proteins, nucleic acids, immunosuppressors, vasoconstrictors and mixtures thereof. 20. A method according to claim 1 wherein the powder includes a blood product. 21. A method according to claim 1 wherein the sealant further comprises a synthetic polymer selected from poly(lactides), poly(glycolides), poly(lactide-co-glycolides), poly(lactic acids), poly(glycolic acids), polycaprolactones, polyamides, poly(malic acids), polyanhydrides, polyamino acids, polyorthoesters, polyetheresters, polycyanoacrylates, polyphosphazines, polyphosphoesters, polyesteramides, polydiozanones, polyacetals, polyketals, polycarbonates, degradable polyurethanes, polyvinyl pyrrolidones, polyhydroxybutyrates, polyhydoxyvalerates, polyalkylene oxalates, polyalkylene succinates, and copolymers, terpolymers, blends, and mixtures thereof. 22. A method according to claim 1, wherein the powder performs hemostasis, promotes healing and reduces pain.