The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based c
The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
대표청구항▼
1. An adherent, self-assembled phosphorous-based coating layer bonded to the native oxide surface of a titanium material substrate, prepared by heating a self-assembled phosphorous-based acid layer formed on the surface thereof until said layer is bonded thereto, wherein said phosphorous-based acid
1. An adherent, self-assembled phosphorous-based coating layer bonded to the native oxide surface of a titanium material substrate, prepared by heating a self-assembled phosphorous-based acid layer formed on the surface thereof until said layer is bonded thereto, wherein said phosphorous-based acid is an organophosphonic acid containing a hydrocarbon ligand having from about 2 to 40 carbon atoms, said hydrocarbon ligand comprising a linear or branched, saturated or unsaturated, substituted or unsubstituted aliphatic or aromatic alkylene moiety. 2. The coating layer of claim 1, wherein said hydrocarbon ligand is a saturated or unsaturated, substituted or unsubstituted alkyl group. 3. The coating layer of claim 1, wherein said hydrocarbon ligand is substituted by an aromatic substituent. 4. The coating layer of claim 1 wherein said hydrocarbon contains a ligand comprising an aromatic moiety. 5. The coating layer of claim 1, wherein said hydrocarbon ligands are omega-substituted. 6. The coating layer of claim 1, wherein said hydrocarbon ligands are substituted at one or more carbon positions. 7. The coating layer of claim 5, wherein said omega-substituent is selected from the group consisting of hydroxyl, amino, carboxylate and thiol groups. 8. An implantable device having one or more surfaces for attachment to bone tissue, wherein at least one attachment surface comprises an adherent, self-assembled phosphorous-based coating layer bonded to the native oxide surface of a material, prepared by heating a self-assembled phosphorous-based acid layer formed on the surface thereof until said layer is bonded thereto, wherein said phosphorous-based acid is selected from the group consisting of phosphoric acid and organophosphonic acids. 9. An adherent, self-assembled phosphorous-based coating layer bonded to the native oxide surface of a titanium material substrate, prepared by heating a self-assembled phosphorous-based acid layer formed on the surface thereof until said layer is bonded thereto, wherein said titanium material is a titanium alloy. 10. The coating layer of claim 9, wherein said titanium alloy is alloy Ti-6Al-4V. 11. The implantable device of claim 8, wherein said native oxide surface is bonded to a material selected from the group consisting of metal, metal oxide, ceramic, and polymers. 12. The implantable device of claim 8 wherein said coating layer is formed on the native oxide surface of a titanium material substrate. 13. The implantable device of claim 12, comprising a knee or hip replacement joint. 14. The implantable device of claim 12, wherein said titanium material substrate comprises titanium or an alloy thereof. 15. The implantable device of claim 11, wherein said native oxide surface comprises a titanium oxide surface.
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