The present invention relates to a device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as
The present invention relates to a device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as an artificial implant, vascular or nonvascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.
대표청구항▼
1. A device comprising: a substrate comprising an intermetallic compound of nickel and titanium;a TiO2 layer disposed on the substrate and produced by electropolishing and plasma treatment of the substrate resulting in a uniform oxidation of the surface;an adhesion promoter disposed above the substr
1. A device comprising: a substrate comprising an intermetallic compound of nickel and titanium;a TiO2 layer disposed on the substrate and produced by electropolishing and plasma treatment of the substrate resulting in a uniform oxidation of the surface;an adhesion promoter disposed above the substrate; anda coating, disposed on the adhesion promoter, comprising a polymer having the general formula (I), wherein n is 2 to ∞, the radicals R1 to R6 are identical or different and are selected from an alkoxy, alkyl sulfonyl, dialkylamino, aryloxy radical, a heterocycloalkyl radical having nitrogen as a heteroatom, and a heteroaryl radical having nitrogen as a heteroatom. 2. The device of claim 1, wherein at least one of the radicals R1 to R6 is an alkoxy radical which is substituted by at least one fluorine atom. 3. The device of claim 1, wherein the polymer is poly[bis(trifluoroethoxy)phosphazene]. 4. The device of claim 1, wherein the adhesion promoter is a compound containing a polar end group. 5. The device claim 1, wherein the adhesion promoter is an organosilicon compound. 6. The device of claim 5, wherein the organosilicon compound is aminopropyltrimethoxysilane. 7. The device of claim 1, wherein the substrate is formed as a stent. 8. The device of claim 1, wherein the coating is microstructured. 9. The device of claim 1, wherein the device is selected from the group consisting of an artificial implant, a vascular stent, a non-vascular stent, a catheter, a thrombolectomy catheter, an embolectomy catheter, a fragmentation spindle, a fragmentation catheter, a filter, a vascular connector, a hernia patch, an oral implant, a dental implant, a throat implant, a guide wire, and a ureter. 10. The device of claim 1, wherein the coating further comprises one or more pharmaceutically active compounds released in a controlled manner over an extended period. 11. The device of claim 1, wherein the coating has a thickness ranging from approximately 1 nm to approximately 100 μm. 12. The device of claim 1, wherein the polymer is poly[bis(trifluoroethoxy)phosphazene], the adhesion promoter comprises an aminopropyl-trimethoxysilane, the substrate is formed as at least a partially perforated tube, and the coating is micro-structured. 13. The device of claim 1, wherein the coating has a thickness ranging from approximately 0.1 nm to approximately 300 μm. 14. The device of claim 1, wherein the TiO2 layer remains as formed beneath the adhesion promoter and coating. 15. The device of claim 1, wherein the TiO2 layer is produced by electropolishing followed by plasma treatment. 16. A process for producing a device comprising: providing a substrate comprising an intermetallic compound of nickel and titanium;exposing the substrate to electropolishing and a plasma treatment resulting in a uniform oxidation of the surface of the substrate to form a TiO2 layer above the substrate;disposing an adhesion promoter; andcoating the adhesion promoter with at least one polymer according to the formula (I), wherein n is 2 to 00, the radicals R1 to R6 are identical or different and are selected from an alkoxy, alkyl sulfonyl, dialkylamino, aryloxy radical, a heterocycloalkyl radical having nitrogen as a heteroatom, and a heteroaryl radical having nitrogen as a heteroatom. 17. The process of claim 11, wherein exposing the substrate to the plasma treatment includes utilizing air, argon, or oxygen plasma. 18. The process of claim 16, further comprising microstructuring a surface of the polymer coating by exposing to a laser beam, an electron beam or X-ray radiation, and/or a heated wire. 19. The process of claim 16, further comprising hydroxylating the substrate subsequent to the plasma treatment and before disposing an adhesion promoter. 20. The process of claim 16, wherein exposing the substrate to the plasma treatment includes utilizing air, argon, or oxygen plasma. 21. The process of claim 16 further comprising microstructuring the polymer coating, by exposing to a laser beam, an electron beam or X-ray radiation, and/or a heated wire. 22. The process of claim 16, wherein coating the substrate with at least one polymer further comprises spraying or dipping in a polymer solution containing at least one compound of the general formula (I) at a concentration of about 0.1 to 99% by weight. 23. The process of claim 16, wherein the coating has a thickness ranging from approximately 0.1 nm to approximately 300 μm. 24. The process of claim 16, wherein the coating has a thickness ranging from approximately 1 nm to approximately 100 μm. 25. The process of claim 16, wherein the TiO2 layer remains as formed through the coating step. 26. The process of claim 16, wherein the TiO2 layer is produced by electropolishing followed by plasma treatment.
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