Citrate anticoagulation system for extracorporeal blood treatments
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-001/34
A61M-001/36
출원번호
US-0602827
(2006-11-21)
등록번호
US-8105258
(2012-01-31)
우선권정보
EP-99201302 (1999-04-26)
발명자
/ 주소
Lannoy, Jean-Michel
출원인 / 주소
Baxter International Inc.
대리인 / 주소
K & L Gates LLP
인용정보
피인용 횟수 :
3인용 특허 :
58
초록▼
A hemofiltration system and method for pumping blood from a patient's blood stream into an access line, introducing an anticoagulant solution into the pumped blood, filtering the pumped blood and delivering it to a return line, introducing a substitution fluid into the pumped blood, introducing a ca
A hemofiltration system and method for pumping blood from a patient's blood stream into an access line, introducing an anticoagulant solution into the pumped blood, filtering the pumped blood and delivering it to a return line, introducing a substitution fluid into the pumped blood, introducing a calcium and magnesium solution into the blood traveling through the return line, and returning the blood back to the patient's blood stream.
대표청구항▼
1. A filtration system comprising: an access line configured to carry blood from a patient's blood stream;a first pump configured to pump the blood through the access line;a supply of citrate anticoagulant solution;a second pump connected to the supply of citrate anticoagulant solution for introduci
1. A filtration system comprising: an access line configured to carry blood from a patient's blood stream;a first pump configured to pump the blood through the access line;a supply of citrate anticoagulant solution;a second pump connected to the supply of citrate anticoagulant solution for introducing the citrate anticoagulant solution into the blood traveling through the access line;a supply of substitution fluid;a third pump connected to the supply of substitution fluid for introducing the substitution fluid into the blood traveling through the access line;a filter for filtering the blood traveling through the access line, the filter outputting filtered blood back to the patient's blood stream;a fourth pump connected to the supply of substitution fluid for introducing said substitution fluid into the filtered blood;a supply of a calcium and magnesium solution;a fifth pump connected to the supply of the calcium and magnesium solution for introducing the calcium and magnesium solution into the filtered blood; anda processing unit for controlling a flow rate for the first pump, the second pump, the third pump, the fourth pump and the fifth pump,wherein the processing unit is selectable to provide a first therapy for which both the third and fourth pumps are operated and a second therapy in which the third pump is operated but the fourth pump is not operated. 2. The filtration system of claim 1, wherein the third pump is coupled to the access line between the second pump and the filter. 3. The filtration system of claim 1, wherein the fourth pump is coupled to the return line between the filter and the fifth pump. 4. The filtration system of claim 1, wherein the filter is further configured to receive dialysate to perform hemodiafiltration. 5. The filtration system of claim 1, further comprising a heater to heat the substitution fluid introduced into the blood to a temperature substantially equal to the patient's body temperature. 6. The filtration system of claim 1, further comprising a pressure monitor coupled to the access line to monitor the blood pressure in the access line. 7. The filtration system of claim 1, further comprising a pressure monitor coupled to the return line to monitor the blood pressure in the return line. 8. The filtration system of claim 1, further comprising: a filtrate line coupled to the filter and configured to carry a filtrate from the filter; anda pressure monitor coupled to the filtrate line to control filtrate pressurization. 9. The filtration system of claim 1, further comprising: a filtrate line coupled to the filter and configured to carry a filtrate from the filter; anda blood leak detector chamber coupled to the filtrate line to control leakage of blood cells through the filter. 10. The filtration system of claim 1, further comprising: a filtrate line coupled to the filter and configured to carry a filtrate from the filter;a reservoir to collect the filtrate traveling through the filtrate line;a measuring scale to weigh the filtrate collected in the reservoir;wherein the processing unit computes the amount of substitution fluid introduced in the blood from the weight measured by the scale,wherein the processing unit controls the flow rate of the third pump, the fourth pump and the fifth pump to introduce the computed amount of substitution fluid to the blood. 11. The filtration system of claim 1, further comprising an air detector to detect air bubbles from the blood introduced with the substitution fluid. 12. The filtration system of claim 1, further comprising: an air trap to remove air bubbles from the blood before it is returned to the patient's blood stream. 13. The filtration system of claim 1, further comprising: an air trap to remove air bubbles from the blood traveling through the return line;wherein the fourth pump is coupled to the return line pre-air trap. 14. A filtration system comprising: an access line configured to carry blood from a patient's blood stream;a first pump configured to pump the blood through the access line;a supply of citrate anticoagulant solution;a second pump connected to the supply of citrate anticoagulant solution for introducing the citrate anticoagulant solution into the blood traveling through the access line;a supply of substitution fluid;a third pump connected to the supply of substitution fluid for introducing the substitution fluid into the blood;a filter for filtering the blood traveling through the access line, the filter outputting filtered blood to a return line configured to carry blood back to the patient's blood stream;a fourth pump connected to the supply of substitution fluid for introducing said substitution fluid into the return line;a supply of a calcium and magnesium solution;a fifth pump connected to the supply of the calcium and magnesium solution for introducing the calcium and magnesium solution into the return line; anda processing unit for controlling a flow rate for the first pump, the second pump, the third pump, the fourth pump and the fifth pumpwherein the processing unit is programmed to be selectable to operate in a first therapy to cause the flow rate of both the third and fourth pumps during filtration to be greater than zero or to operate in a second therapy to cause the flow rate of the third pump during filtration to be greater than zero and the flow rate of the fourth pump to be zero. 15. The filtration system of claim 14, wherein the third pump is coupled to the access line between the first pump and the filter. 16. The filtration system of claim 14, further comprising: a filtrate line coupled to the filter and configured to carry the filtrate from the filter; anda pressure monitor coupled to the filtrate line to control filtrate pressurization. 17. The filtration system of claim 14, further comprising: a filtrate line coupled to the filter and configured to carry a filtrate from the filter; anda blood leak detector chamber coupled to the filtrate line to control leakage of blood cells through the filter. 18. The filtration system of claim 14, further comprising: a filtrate line coupled to the filter and configured to carry a filtrate from the filter;a reservoir to collect the filtrate traveling through the filtrate line;a sixth pump for pumping the filtrate from the filter into the reservoir; anda measuring scale to weigh the filtrate collected in the reservoir;wherein the processing unit computes the amount of substitution fluid introduced in the blood from the weight measured by the scale,wherein the processing unit controls the flow rate of the third pump, the fourth pump, the fifth pump and the sixth pump to introduce the computed amount of substitution fluid to the blood. 19. The filtration system of claim 14, further comprising: an air detector to detect air bubbles from the blood introduced with the substitution fluid; andan air trap to remove air bubbles from the blood before it is returned into the patient's blood stream. 20. The filtration system of claim 14, further comprising a heater to heat the substation fluid introduced into the blood to a temperature substantially equal to the patient's body temperature. 21. The filtration system of claim 14, wherein the substitution fluid introduced by the third pump and the substitution fluid introduced by the fourth pump are substantially similar. 22. The filtration system of claim 14, wherein the filter is further configured to receive dialysate to perform hemodiafiltration. 23. A blood filtration system comprising: an access line configured to carry blood from a patient's blood stream;a supply of citrate anticoagulant solution;a supply of substitution solution;a supply of a calcium and magnesium solution;a first pump in fluid communication with the access line;a second pump connected to the supply of citrate anticoagulant solution and in fluid communication with the access line;a third pump connected to the supply of substitution solution and in fluid communication with the access line;a filter for filtering the blood carried in the access line, the filter configured to output filtered blood into a return line;a fourth pump connected to the supply of substitution solution and in fluid communication with the return line;a fifth pump connected to the supply of the calcium and magnesium solution and in fluid communication with the return line; anda controller including at least one processor and at least one memory device which stores a plurality of instructions, which when executed by the at least one processor, cause the controller to operate with the first pump, the second pump, the third pump, the fourth pump and the fifth pump to: cause the first pump to pump the blood through the access line;cause the second pump to introduce the anticoagulant solution into the blood traveling through the access line;cause the third pump during first and second selectable therapies to introduce the substitution solution into the blood traveling through the access line;cause the fourth pump during the first but not the second therapy to introduce the substitution fluid into the filtered blood traveling through the return line; andcause the fifth pump to introduce the calcium and magnesium solution into the filtered blood traveling through the return line. 24. The blood filtration system of claim 23, wherein at least one of: the second pump is downstream from the first pump, the third pump is downstream from the second pump, and the fifth pump is downstream of the fourth pump.
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