IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0020717
(2011-02-03)
|
등록번호 |
US-8105262
(2012-01-31)
|
발명자
/ 주소 |
- Noda, Wayne A.
- Jones, Mike L.
- Evans, Scott M.
- Walker, Blair D.
- Worthen, William J.
- Gobin, Yves Pierre
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
19 인용 특허 :
10 |
초록
▼
A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat
A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.
대표청구항
▼
1. Apparatus comprising: a catheter body having at least one heat exchange fluid lumen; andat least one heat exchange element communicating with the lumen such that heat exchange fluid is flowing through the heat exchange element to exchange heat with blood of a patient when the heat exchange elemen
1. Apparatus comprising: a catheter body having at least one heat exchange fluid lumen; andat least one heat exchange element communicating with the lumen such that heat exchange fluid is flowing through the heat exchange element to exchange heat with blood of a patient when the heat exchange element is positioned in a bloodstream of the patient, the heat exchange fluid not entering the bloodstream, wherein the body has a stiffness at a first location of the body that is different from a stiffness at a second location of the body;wherein first and second heat exchange elements are separated from each other by a flex region having a different configuration than the heat exchange elements. 2. The apparatus of claim 1, wherein the first location has a first diameter and the second location has a second diameter different from the first location. 3. The apparatus of claim 1, wherein at least one heat exchange element is externally fluted in a spiral configuration along at least a segment thereof, wherein body fluid laterally outward of the heat exchange element cannot flow between the heat exchange element and a long axis defined by the spiral configuration of the heat exchange element. 4. The apparatus of claim 1, comprising plural heat exchange elements axially arranged along the body and separated by plural flex regions such that the catheter can bend and flex when placed in a curved vasculature and is not as rigid, stiff and inflexible by comparison to a single heat exchange element catheter. 5. The apparatus of claim 1, comprising an anti-thrombogenic coating on at least a portion of the catheter. 6. The apparatus of claim 1, comprising a hydrophilic or hydrophobic coating on at least one heat exchange element. 7. The apparatus of claim 1, wherein a pressure gradient is established from a first end of the heat exchange element to a second end thereof. 8. Apparatus comprising: a catheter body having at least one heat exchange fluid lumen; andat least one heat exchange element communicating with the lumen such that heat exchange fluid is flowing through the heat exchange element to exchange heat with a patient when the heat exchange element is positioned in the patient, the heat exchange fluid substantially not entering a bloodstream of the patient, wherein the body has a stiffness at a first location of the body that is different from a stiffness at a second location of the body; andwherein at least one heat exchange element is spiral-shaped but does not constrain all of the heat exchange fluid to flow in a spiral path. 9. The apparatus of claim 8, wherein the first location has a first diameter and the second location has a second diameter different from the first location. 10. The apparatus of claim 8, wherein at least one heat exchange element is configured to enhance heat exchange by being configured with at least one irregular surface next to which blood and/or heat exchange fluid flows. 11. The apparatus of claim 8, wherein the spiral-shaped heat exchange element is made of temperature-independent material such that the spiral-shaped heat exchange element maintains its spiral shape regardless of any internal or surrounding temperatures. 12. The apparatus of claim 10, wherein the irregular surface is established by structure defining peaks and valleys to upset laminar flow of fluid. 13. The apparatus of claim 10, wherein the irregular surface is established by ridges. 14. The apparatus of claim 8, wherein a single heat exchange element is formed with plural helical flutes. 15. The apparatus of claim 14, wherein tips of helical flutes on the heat exchange element define walls having a thickness greater than a thickness of other portions of the catheter. 16. The apparatus of claim 8, wherein first and second heat exchange elements are separated from each other by a flex region. 17. The apparatus of claim 8, wherein the spiral-shaped heat exchange element is externally fluted in a spiral configuration along at least a segment thereof, wherein body fluid laterally outward of the heat exchange element cannot flow between the heat exchange element and a long axis defined by the spiral configuration of the heat exchange element. 18. The apparatus of claim 8, comprising plural heat exchange elements axially arranged along the body such that the catheter can bend and flex when placed in a curved vasculature and is not as rigid, stiff and inflexible by comparison to a single heat exchange element catheter. 19. The apparatus of claim 8, comprising an anti-thrombogenic coating on at least a portion of the catheter. 20. The apparatus of claim 16, wherein the heat exchange elements extend axially along a surface of the body. 21. The apparatus of claim 8, comprising a hydrophilic or hydrophobic coating on at least one heat exchange element. 22. The apparatus of claim 8, wherein a pressure gradient is established from a first end of the heat exchange element to a second end thereof. 23. Heat exchange catheter, comprising: a distally located heat exchange region positionable in a blood vessel of a patient, the heat exchange region configured to bear heat exchange fluid flowing through the heat exchange region to exchange heat with blood in the blood vessel, the heat exchange fluid not exiting the catheter into the blood vessel and the heat exchange region not blocking the blood vessel when heat exchange fluid flows through the heat exchange region such that blood flows past the heat exchange region in the blood vessel, wherein the body has a stiffness at a first location of the body that is different from a stiffness at a second location of the body;wherein at least one heat exchange region is formed with plural helical flutes. 24. The catheter of claim 23, wherein the first location has a first diameter and the second location has a second diameter different from the first location. 25. The catheter of claim 23, wherein at least one heat exchange region is configured to enhance heat exchange by being configured with at least one irregular surface next to which blood and/or heat exchange fluid flows. 26. The catheter of claim 25, wherein the irregular surface is spiral-shaped. 27. The catheter of claim 25, wherein the irregular surface is established by structure defining peaks and valleys to upset laminar flow of fluid. 28. The catheter of claim 25, wherein the irregular surface is established by ridges. 29. The catheter of claim 23, wherein first and second heat exchange regions are separated from each other by a flex region. 30. The catheter of claim 23, wherein at least one heat exchange region is externally fluted in a spiral configuration along at least a segment thereof, wherein body fluid laterally outward of the heat exchange region cannot flow between the heat exchange region and a long axis defined by the spiral configuration of the heat exchange region. 31. The catheter of claim 23, comprising plural heat exchange regions axially arranged along the body such that the catheter can bend and flex when placed in a curved vasculature and is not as rigid, stiff and inflexible by comparison to a single heat exchange region catheter. 32. The catheter of claim 23, comprising an anti-thrombogenic coating on at least a portion of the catheter. 33. The catheter of claim 23, comprising a hydrophilic or hydrophobic coating on at least one heat exchange region. 34. The catheter of claim 23, wherein a pressure gradient is established from a first end of the heat exchange region to a second end thereof.
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