IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0275521
(2001-05-18)
|
등록번호 |
US-8105351
(2012-01-31)
|
국제출원번호 |
PCT/US01/40766
(2001-05-18)
|
§371/§102 date |
20030605
(20030605)
|
국제공개번호 |
WO01/89370
(2001-11-29)
|
발명자
/ 주소 |
- Lehman, Glen
- Filipi, Charles J.
|
출원인 / 주소 |
|
대리인 / 주소 |
Wolf, Greenfield & Sacks, P.C.
|
인용정보 |
피인용 횟수 :
6 인용 특허 :
271 |
초록
▼
The present invention provides methods and devices for promoting tissue adhesion, which utilizes the healing process and scar tissue formation to bond two tissue surfaces together. A tissue injury is accomplished by destroying the mucosal layer of tissue. After the injury is initiated, the tissue is
The present invention provides methods and devices for promoting tissue adhesion, which utilizes the healing process and scar tissue formation to bond two tissue surfaces together. A tissue injury is accomplished by destroying the mucosal layer of tissue. After the injury is initiated, the tissue is preferably held in close contact by a tissue apposition means such as a suture, staple or clip device placed adjacent to the treatment site. The tissue injury may be initiated by electrical/radiofrequency energy or chemical or mechanical means integrated with the tissue apposition device or delivered by a separate instrument such as an electrocautery catheter through an endoscope. As scar tissue created by the injury forms, the tissue surfaces become bonded together in a permanent union.
대표청구항
▼
1. A method of promoting tissue adhesion between tissue surfaces, comprising: placing a fastener through tissue having the tissue surfaces;after and separate from placing the fastener through the tissue, injuring an area of each tissue surface to be joined to initiate an injury response in the tissu
1. A method of promoting tissue adhesion between tissue surfaces, comprising: placing a fastener through tissue having the tissue surfaces;after and separate from placing the fastener through the tissue, injuring an area of each tissue surface to be joined to initiate an injury response in the tissue that will result in scar tissue formation;placing the tissue surfaces to be joined in contact after injuring the area of each tissue surface to be joined; andsecuring the injured tissue surfaces in contact with the fastener for at least the period encompassing the resulting scar tissue formation. 2. The method of promoting tissue adhesion as defined in claim 1, wherein the tissue surfaces are secured in contact by a suture. 3. The method of promoting tissue adhesion as defined in claim 2, wherein the suture is secured by a knot. 4. The method of promoting tissue adhesion as defined in claim 2, wherein the suture is secured by a suture lock device. 5. The method of promoting tissue adhesion as defined in claim 1, wherein the injury destroys the mucosal layer of the affected areas of tissue. 6. The method of promoting tissue adhesion as defined in claim 1, wherein the injury is created by electrical energy. 7. The method of promoting tissue adhesion as defined in claim 6, wherein the energy is radiofrequency energy. 8. The method of promoting tissue adhesion as defined in claim 6, wherein the radiofrequency energy is applied by an electrocautery catheter. 9. The method of promoting tissue adhesion as defined in claim 6, wherein the injury created by the radiofrequency energy is supplemented by application of sodium oleate. 10. The method of promoting tissue adhesion as defined in claim 1, wherein the injury is created by a chemical substance. 11. The method of promoting tissue adhesion as defined in claim 10, wherein injury is created by application of sodium oleate. 12. The method of promoting tissue adhesion as defined in claim 1, wherein the injury is created by mechanical means to abrade the tissue. 13. The method of promoting tissue adhesion as defined in claim 1, wherein the tissue surfaces comprise external tissue of the human body. 14. The method of promoting tissue adhesion as defined in claim 1, wherein the tissue surfaces comprises internal tissue of the human body. 15. The method of promoting tissue adhesion as defined in claim 14, wherein the injury is created between and on facing surfaces of tissue folds previously collected and through which a suture has been passed. 16. The method of promoting tissue adhesion as defined in claim 15, further comprising tightening the suture to draw the tissue folds and injured surfaces together after the injury has been created. 17. The method of promoting tissue adhesion between tissue surfaces as defined in claim 1, wherein the tissue is gastric tissue and the injury is applied to the mucosal layer of the gastric tissue. 18. The method of promoting tissue adhesion as defined in claim 1, wherein the method is performed endoscopically. 19. A method of promoting tissue adhesion between tissue surfaces, comprising: collecting tissue with tissue surfaces facing each other;placing a fastener through the collected tissue;after and separate from placing the fastener through the collected tissue, creating a tissue injury on each tissue surface that faces the other, wherein the tissue injury is sufficient to result in scar tissue formation;placing the injured tissue surfaces in contact after creating the tissue injury on each tissue surface; andsecuring the injured tissue surfaces in contact with the fastener for at least the period encompassing the resulting scar tissue formation. 20. A method of promoting tissue adhesion between tissue surfaces, comprising: collecting two areas of tissue that are to be joined by adhesion;placing a fastener through the collected tissue;after and separate from placing the fastener through the collected tissue, creating a tissue injury on the tissue surface of each area, wherein the tissue injury is sufficient to result in scar tissue formation;placing the injured tissue surfaces in contact after creating the tissue injury on each tissue surface; andsecuring the injured surfaces in contact with the fastener for at least the period encompassing the resulting scar tissue formation. 21. A method of promoting tissue adhesion between tissue surfaces, comprising: collecting a first tissue area into a first fold;placing a fastener through the tissue in the first fold;collecting a second tissue area, adjacent to the first tissue area, into a second fold;placing the fastener through the tissue in the second fold;after placing the fastener through the tissue of the first and second folds, creating a tissue injury on tissue surfaces of the first and second folds, wherein the tissue injury is sufficient to result in scar tissue formation;placing the injured tissue surfaces in contact after creating the tissue injury on the tissue surfaces; andsecuring the injured surfaces in contact with the fastener for at least the period encompassing the resulting scar tissue formation.
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