Method for molding and assembling containers with stoppers and filling same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B65B-051/10
B65B-055/02
출원번호
US-0715821
(2010-03-02)
등록번호
US-8112972
(2012-02-14)
발명자
/ 주소
Py, Daniel
출원인 / 주소
Medical Instill Technologies, Inc.
대리인 / 주소
McCarter & English, LLP
인용정보
피인용 횟수 :
5인용 특허 :
62
초록▼
A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Th
A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.
대표청구항▼
1. A method comprising the following steps: (a) molding a container body in a first mold cavity;(b) molding a resealable member in a second mold cavity;(c) assembling at least one of the container body and resealable member to the other at container body and resealable member temperatures greater th
1. A method comprising the following steps: (a) molding a container body in a first mold cavity;(b) molding a resealable member in a second mold cavity;(c) assembling at least one of the container body and resealable member to the other at container body and resealable member temperatures greater than an ambient temperature, said assembling further including at least one of: (i) moving the resealable member into engagement with the container body which is located at least partially within the first mold cavity, assembling the resealable member to the container body, and forming a substantially sterile, sealed container body and resealable member assembly;(ii) moving the container body into engagement with the resealable member which is located at least partially within the second mold cavity, assembling the container body to the resealable member, and forming a substantially sterile, sealed container body and resealable member assembly; and(iii) assembling at least one of the container body and resealable member to the other with each of the container body and resealable member at a bactericidal temperature, and forming a substantially sterile, sealed container body and resealable member assembly;(d) transferring the container body and resealable member assembly to a filling and resealing apparatus including at least one filling member;(e) penetrating the resealable member with the filling member and introducing a substance from the filling member through the penetrated resealable member and into an interior chamber of the container body at a temperature substantially less than the container body and resealable member temperature at assembly thereof;(f) withdrawing the filling member from the resealable member; and(g) sealing a penetrated region of the resealable member. 2. A method as defined in claim 1, further comprising the steps of: configuring the first and second mold cavities and an assembly device, and the filling and resealing apparatus in line relative to each other; andtransferring the assembled container body and resealable member assembly from at least one of the first mold cavity, second mold cavity and assembly device to the filling and resealing apparatus. 3. A method as defined in claim 1, further comprising the step of transmitting e-beam radiation onto at least one of (i) the assembled container body and resealable member assembly prior to filling and resealing thereof, and (ii) the assembled container body and resealable member assembly and filling member during filling and resealing thereof. 4. A method as defined in claim 1, wherein the step of molding a container body comprises molding a container body defining an opening in communication with an interior chamber thereof for receiving a substance therein. 5. A method as defined in claim 1, wherein the assembling step comprises assembling at least one of the container body and resealable member to the other upon removal of at least one of the container body and resealable member from the respective mold cavity. 6. A method as defined in claim 1, wherein the step of moving the resealable member into engagement with the container body comprises transferring the resealable member from the second mold cavity into engagement with the container body. 7. A method as defined in claim 1, wherein the step of moving the container body into engagement with the resealable member comprises transferring the container body from the first mold cavity into engagement with the resealable member. 8. A method as defined in claim 1, wherein the container body and resealable member temperatures in each of steps (c)(i) and (c)(ii) are bactericidal. 9. A method as defined in claim 1, wherein the container body and resealable member temperatures at assembly are each greater than approximately 80° C. 10. A method as defined in claim 1, wherein the container body and resealable member temperatures at assembly are each within the range of about 80° C. through about 140° C. 11. A method as defined in claim 1, wherein the at least one filling member comprises at least one needle. 12. A method as defined in claim 1, wherein the filling and resealing apparatus includes a thermal source. 13. A method as defined in claim 12, wherein the thermal source includes a laser. 14. A method as defined in claim 12, wherein the step of sealing the penetrated region comprises thermally resealing the penetrated region with the thermal source. 15. A method as defined in claim 14, further comprising the step of sensing the temperature of the thermally resealed portion of the resealable member, and determining whether the temperature of the resealed surface of the resealable member is greater than the melting temperature of the resealable member material and less than the vaporization temperature of the resealable member material. 16. A method as defined in claim 15, further comprising the step of comparing the sensed temperature to at least one predetermined temperature to determine whether a penetration hole in the resealable member is sealed. 17. A method as defined in claim 1, further comprising the step of directing a substantially laminar flow of substantially sterile gas over the container body and resealable member during assembly thereof. 18. A method as defined in claim 17, wherein the directing step comprises directing the flow downwardly over the container body and resealable member during assembly thereof. 19. A method as defined in claim 17, wherein the directing step comprises directing the flow laterally over the container body and resealable member during assembly thereof. 20. A method as defined in claim 1, further comprising providing a barrier enclosure defining an aseptic chamber including therein at least one of the first mold cavity, the second mold cavity and an assembly device, and assembling within the aseptic chamber the resealable member and container body. 21. A method as defined in claim 20, further comprising surrounding the first mold cavity, the second mold cavity and the assembly device with the barrier enclosure. 22. A method as defined in claim 21, further comprising providing the first mold cavity in a first molding machine, the second mold cavity in a second molding machine, and locating the first and second molding machines within the barrier enclosure. 23. A method as defined in claim 1, wherein the step of introducing a substance into the interior chamber of the container body comprises aseptically filling the interior chamber. 24. A method as defined in claim 23, wherein the container body and resealable member assembly is at a substantially ambient temperature during said aseptic filling. 25. A method as defined in claim 1, further comprising configuring the filling and resealing apparatus in line with an assembly device with a barrier enclosure extending therebetween, and transferring the assembled container body and resealable member assembly from the assembly device, through the barrier enclosure, and to the filling and resealing apparatus.
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