Electrochemical systems for measuring an analyte concentration, and correcting any surplus or deficiency in the measured concentration. More specifically, systems for measuring an analyte level in a fluid with an implantable sensor, processing the measurements with an algorithm, and determining an a
Electrochemical systems for measuring an analyte concentration, and correcting any surplus or deficiency in the measured concentration. More specifically, systems for measuring an analyte level in a fluid with an implantable sensor, processing the measurements with an algorithm, and determining an appropriate fluid infusion rate in response to the measurements.
대표청구항▼
1. A method of determining a fluid infusion rate for infusing a fluid containing insulin into a user, comprising using a glucose detection device to monitor concentration of glucose in the user and generating a sensor output signal based on the monitored concentration,using the sensor output signal
1. A method of determining a fluid infusion rate for infusing a fluid containing insulin into a user, comprising using a glucose detection device to monitor concentration of glucose in the user and generating a sensor output signal based on the monitored concentration,using the sensor output signal to generate a processor input signal,processing the processor input signal using a fading memory proportional derivative algorithm to generate a processor output signal,determining a fluid infusion rate based at least partially on the processor output signal wherein the fluid contains insulin,delivering the fluid containing insulin into the user, anddelivering a glucose-increasing substance to the user when the user's glucose concentration is falling at a rate above a pre-determined threshold, and the user's glucose concentration has fallen below a pre-determined threshold level. 2. The method of claim 1, wherein the glucose-increasing substance is selected from the following: (a) glucagon, (b) glucagon-like agent, (c) glucose, and (d) dextrose, and mixtures thereof. 3. The method of claim 1, further comprising receiving the sensor output signal at a transmitter electrically coupled to the sensor, converting the sensor output signal to the processor input signal with the transmitter, and transmitting the processor input signal to the processor with the transmitter. 4. The method of claim 1, wherein determining the fluid infusion rate also is based on at least one of the following traits of the user: insulin sensitivity, age, body weight, usual total daily insulin dose, or physical adiposity. 5. The method of claim 1 further comprising implanting the glucose detection device in the user. 6. A method of determining a fluid infusion rate for infusing a fluid containing insulin into a user, comprising using a glucose detection device to monitor concentration of glucose in the user and generating a sensor output signal based on the monitored concentration,using the sensor output signal to generate a processor input signal,processing the processor input signal using a fading memory proportional derivative algorithm to generate a processor output signal,determining the fluid infusion rate based at least partially on the processor output signal,delivering the fluid containing insulin into the user, anddelivering a glucose-increasing substance to the user when the user's glucose concentration is falling, the timing and amount of glucose-increasing substance delivered being based on a proportional error of glucose concentration and a derivative error of glucose concentration. 7. The method of claim 6, wherein the timing and amount of glucose-increasing substance delivered is based at least partially on a fading memory calculation relative to the proportional error. 8. The method of claim 6, wherein the timing and amount of the glucose-increasing substance delivered is based at least partially on a fading memory calculation relative to the derivative error. 9. The method of claim 6, wherein the timing and amount of the glucose-increasing substance delivered is based at least partially on fading memory calculations relative to the proportional error and the derivative error, a longer history being considered relative to the proportional error compared to the history considered for the derivative error.
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이 특허에 인용된 특허 (23)
Say, James; Tomasco, Michael F.; Heller, Adam; Gal, Yoram; Aria, Behrad; Heller, Ephraim; Plante, Phillip John; Vreeke, Mark S.; Friedman, Keith A.; Colman, Fredric C., Analyte monitoring device and methods of use.
Steil, Garry M.; Rebrin, Kerstin; Goode, Jr., Paul V.; Mastrototaro, John J.; Purvis, Richard E.; Van Antwerp, William P.; Shin, John J.; Talbot, Cary D., Closed loop system for controlling insulin infusion.
Bessman Samuel P. (2025 Zonal Ave. Los Angeles CA 90033) Layne Ennis C. (9128 Huntington Dr. San Gabriel CA 91775) Thomas Lyell J. (1900 Pelican Ave. San Pedro CA 90732), Implantable glucose sensor.
Newhouse Stanley (206 Juniper Cir. North Lawrence NY 11559) Lerner Robert (315 E. 65th St. New York NY 10021) Martin Roy (3312 182nd Pl. ; NE. Redmond WA 98452), Insulin delivery method and apparatus.
Berner Bret ; Dunn Timothy C. ; Farinas Kathleen C. ; Garrison Michael D. ; Kurnik Ronald T. ; Lesho Matthew J. ; Potts Russell O. ; Tamada Janet A. ; Tierney Michael J., Signal processing for measurement of physiological analysis.
Starkweather, Timothy J.; Lebel, Ronald J.; Shah, Rajiv; Miller, Michael E., System and method for providing closed loop infusion formulation delivery.
DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
Verhoef, Erik T.; DiPerna, Paul M.; Rosinko, Mike; Williamson, Mark; Kruse, Geoffrey A.; Ulrich, Thomas R.; Lamb, Phil; Saint, Sean; Michaud, Michael; Trevaskis, William, Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
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