Clay-based hemostatic agents and devices for the delivery thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-015/14
A61L-015/16
A61L-015/18
A61K-009/14
A61F-013/00
출원번호
US-0581782
(2009-10-19)
등록번호
US-8114433
(2012-02-14)
발명자
/ 주소
Huey, Raymond J.
Lo, Denny
Burns, Daniel J.
Basadonna, Giacomo
Hursey, Francis X.
출원인 / 주소
Z-Medica Corporation
대리인 / 주소
Knobbe Martens Olson & Bear, LLP
인용정보
피인용 횟수 :
26인용 특허 :
73
초록▼
A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a
A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.
대표청구항▼
1. A device capable of providing a hemostatic effect on bleeding, said device comprising: a gauze substrate;a clay material disposed on said gauze substrate; anda glycerol binder disposed on said gauze substrate to bind said clay material to said gauze substrate;wherein the gauze substrate initially
1. A device capable of providing a hemostatic effect on bleeding, said device comprising: a gauze substrate;a clay material disposed on said gauze substrate; anda glycerol binder disposed on said gauze substrate to bind said clay material to said gauze substrate;wherein the gauze substrate initially exists separately from the clay material before the gauze and the clay material are combined;wherein the binder has an effect of substantially suppressing clay dust; andwherein said device is substantially dry; andthe device is configured such that when treating bleeding, application of said device is capable of causing at least a portion of said clay material to come into contact with blood to assist in accelerating clotting. 2. The device of claim 1, wherein said clay material is kaolin. 3. The device of claim 1, wherein said clay material is selected from the group consisting of attapulgite, bentonite, kaolin, and combinations of the foregoing materials. 4. The device of claim 1, further comprising a pharmaceutically- active composition selected from the group consisting of antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, compounds containing silver or copper ions, and combinations of the foregoing compositions. 5. The device of claim 1, wherein said gauze substrate is fabricated from a material selected from the group consisting of cotton, silk, wool, plastic, cellulose, rayon, polyester, and combinations of the foregoing. 6. The device of claim 1, wherein said gauze substrate is flexible to allow said gauze substrate to form to a shape of said bleeding wound and to retain a shape of said bleeding wound. 7. The device of claim 1, further comprising a release agent disposed on said clay material. 8. The device of claim 7, wherein said release agent is selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethyl cellulose, and gelatinized starch. 9. The device of claim 1, wherein the kaolin comprises particles having diameters of less than 0.2 mm. 10. The device of claim 1, wherein said gauze substrate is flexible to allow said gauze substrate to form to a shape of said bleeding wound and to retain a shape of said bleeding wound. 11. A device capable of providing a hemostatic effect on bleeding, said device comprising: a gauze substrate;a dispersion comprising kaolin and a glycerol binder disposed on said gauze substrate; anda sterilized packaging;wherein the gauze substrate is provided as a separate component from the kaolin when the device is made;wherein the glycerol binder has an effect of substantially suppressing clay dust; andwherein said device is substantially dry; andthe device is configured such that when treating bleeding, application of said device is capable of causing at least a portion of said kaolin to come into contact with blood to assist in accelerating clotting. 12. The device of claim 11, further comprising a pharmaceutically- active composition selected from the group consisting of antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, compounds containing silver or copper ions, and combinations of the foregoing compositions. 13. The device of claim 11, wherein said gauze substrate is fabricated from a material selected from the group consisting of cotton, silk, wool, plastic, cellulose, rayon, polyester, and combinations of the foregoing. 14. The device of claim 11, wherein said gauze substrate is flexible to allow said gauze substrate to form to a shape of said bleeding wound and to retain a shape of said bleeding wound. 15. The device of claim 11, further comprising a release agent disposed on said kaolin. 16. The device of claim 15, wherein said release agent is selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethyl cellulose, and gelatinized starch. 17. The device of claim 11, wherein the kaolin comprises particles having diameters of less than 0.2 mm. 18. The device of claim 17, wherein said gauze substrate is flexible to allow said gauze substrate to form to a shape of said bleeding wound and to retain a shape of said bleeding wound.
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Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
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