IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0080180
(2011-04-05)
|
등록번호 |
US-8114618
(2012-02-14)
|
발명자
/ 주소 |
- Albitar, Maher
- Keating, Michael J.
- Manshouri, Taghi
|
출원인 / 주소 |
- Board of Regents of the University of Texas System
|
대리인 / 주소 |
Fulbright & Jaworski L.L.P.
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인용정보 |
피인용 횟수 :
5 인용 특허 :
12 |
초록
▼
The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone a
The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.
대표청구항
▼
1. A method of staging a B cell hyperproliferative disease comprising: contacting a sample from a B cell hyperproliferative disease patient with a first anti-CD20 antibody, wherein the first anti-CD20 antibody captures circulating cell-free CD20 in the sample;contacting the captured circulating cell
1. A method of staging a B cell hyperproliferative disease comprising: contacting a sample from a B cell hyperproliferative disease patient with a first anti-CD20 antibody, wherein the first anti-CD20 antibody captures circulating cell-free CD20 in the sample;contacting the captured circulating cell-free CD20 with a second anti-CD20 antibody; andmeasuring the level of the second anti-CD20 antibody, wherein a higher level of the second anti-CD20 antibody correlates with advance stage of the B cell hyperproliferative disease. 2. The method of claim 1 further comprising determining the level of circulating cell-free CD52, wherein a higher level of circulating cell-free CD52 relative to a normal control level is indicative of aggressiveness or more advanced stage of disease. 3. The method of claim 1, wherein the B cell hyperproliferative disease is chronic lymphocytic leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, chronic myelomonocytic leukemia, juvenile myelomonocyte leukemia, multiple myeloma, hairy cell leukemia, prolymphocytic leukemia, or lymphoma. 4. The method of claim 1, wherein the B cell hyperproliferative disease is chronic lymphocytic leukemia. 5. A method of monitoring B cell hyperproliferative disease comprising: contacting a sample from a B cell hyperproliferative disease patient with a first anti-CD20 antibody, wherein the first anti-CD20 antibody captures circulating cell-free CD20 in the sample;contacting the captured circulating cell-free CD20 with a second anti-CD20 antibody; andmeasuring the level of the second anti-CD20 antibody, wherein a higher level of the second anti-CD20 antibody indicates a higher level of circulating cell-free CD20 and wherein a higher level of circulating cell-free CD20 relative to a normal control level is indicative of aggressiveness or more advanced stage of disease. 6. The method of claim 5, wherein the B cell hyperproliferative disease is chronic lymphocytic leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, chronic myelomonocytic leukemia, juvenile myelomonocyte leukemia, multiple myeloma, hairy cell leukemia, prolymphocytic leukemia, or lymphoma. 7. The method of claim 5, wherein the B cell hyperproliferative disease is chronic lymphocytic leukemia. 8. The method of claim 5 further comprising measuring the level of circulating cell-free CD52, circulating cell-free anti-CD52 or circulating cell-free CD52/anti-CD52 complexes, wherein a higher level of circulating cell-free CD52, circulating cell-free anti-CD52 or circulating cell-free CD52/anti-CD52 complexes relative to a normal control level is indicative of aggressiveness or more advanced stage of disease. 9. The method of claim 1, wherein the sample is selected from the group consisting of serum, cell lysate and plasma. 10. The method of claim 1 wherein the first or second anti-CD20 antibody is Rituximab. 11. The method of claim 1 wherein the second anti-CD20 antibody is labeled. 12. The method of claim 11, wherein the labeled second anti-CD20 antibody is Rituximab. 13. The method of claim 5, wherein the sample is selected from the group consisting of serum, cell lysate and plasma. 14. The method of claim 5 wherein the first or second anti-CD20 antibody is Rituximab. 15. The method of claim 5 wherein the second anti-CD20 antibody is labeled. 16. The method of claim 15, wherein the labeled second anti-CD20 antibody is Rituximab.
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