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Guanylate cyclase receptor agonists for the treatment of tissue inflammation and carcinogenesis

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/10
  • A61K-038/12
출원번호 US-0763707 (2010-04-20)
등록번호 US-8114831 (2012-02-14)
발명자 / 주소
  • Shailubhai, Kunwar
  • Nikiforovich, Gregory
  • Jacob, Gary S.
출원인 / 주소
  • Synergy Pharmaceuticals Inc.
대리인 / 주소
    Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
인용정보 피인용 횟수 : 20  인용 특허 : 11

초록

A method of treatment of inflamed, pre-cancerous or cancerous tissue or polyps in a mammalian subject is disclosed. The treatment involves administration of a composition of at least one peptide agonist of a guanylate cyclase receptor and/or other small molecules that enhance intracellular productio

대표청구항

1. A method for treating inflammatory bowel disease in a patient comprising administering to said patient an effective dosage of a peptide consisting of SEQ ID NO:8, wherein said peptide is a (4,12; 7,15) bicycle and wherein said peptide binds a guanylate cyclase receptor and induces cGMP production

이 특허에 인용된 특허 (11)

  1. Waldman Scott A., Compositions that specifically bind to colorectal cancer cells and methods of using the same.
  2. Shailubhai,Kunwar; Nikiforovich,Gregory; Jacob,Gary S., Guanylate cyclase receptor agonists for the treatment of tissue inflammation and carcinogenesis.
  3. Wiegand Roger C. ; Currie Mark G. ; Fok Kam Fook, Human guanylin.
  4. Currie Mark G. (St. Charles MO) Kita Toshihiro (Creve Coeur MO) Fok Kam F. (St. Louis MO) Smith Christine E. (Manchester MO), Human uroguanylin.
  5. Woiszwillo James E. (Milford MA), Macromolecular microparticles and methods of production.
  6. Pamukcu Rifat ; Menander Kerstin B., Method for treating a patient with neoplasia by treatment with a platinum coordination complex.
  7. Waldman Scott A., Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof.
  8. Waldman Scott A., Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof.
  9. Waldman Scott A. (Ardmore PA), Methods of diagnosing colorectal tumors and metastasis thereof.
  10. Waldman Scott A., Methods of treating metastatic colorectal cancer with ST receptor binding compounds.
  11. Waldman Scott A. (Ardmore PA), ST receptor binding compounds and methods of using the same.

이 특허를 인용한 특허 (20)

  1. Riff, Dennis; Jacob, Gary S.; Shailubhai, Kunwar; Griffin, Patrick H., Agonists of guanylate cyclase and their uses.
  2. Shailubhai, Kunwar, Agonists of guanylate cyclase and their uses.
  3. Shailubhai, Kunwar, Agonists of guanylate cyclase and their uses.
  4. Shailubhai, Kunwar, Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders.
  5. Shailubhai, Kunwar; Jacob, Gary S., Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders.
  6. Shailubhai, Kunwar; Jacob, Gary S., Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders.
  7. Shailubhai, Kunwar; Jacob, Gary S., Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders.
  8. Shailubhai, Kunwar; Jacob, Gary S., Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders.
  9. Shailubhai, Kunwar, Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases.
  10. Frank, Helen A.; Mcdonald, Alice; O'Keefe, Theresa L., Anti-GCC antibody molecules and methods for use of same.
  11. Frank, Helen Alison; McDonald, Alice A.; O'Keefe, Theresa L., Anti-GCC antibody molecules and methods for use of same.
  12. Shailubhai, Kunwar, Compositions useful for the treatment of gastrointestinal disorders.
  13. Shailubhai, Kunwar, Compositions useful for the treatment of gastrointestinal disorders.
  14. Comiskey, Stephen; Feng, Rong; Foss, John; Shailubhai, Kunwar, Formulations of guanylate cyclase C agonists and methods of use.
  15. Comiskey, Stephen; Feng, Rong; Foss, John; Shailubhai, Kunwar, Formulations of guanylate cyclase C agonists and methods of use.
  16. Comiskey, Stephen; Feng, Rong; Foss, John; Shailubhai, Kunwar, Formulations of guanylate cyclase C agonists and methods of use.
  17. Comiskey, Stephen; Feng, Rong; Foss, John; Shailubhai, Kunwar, Formulations of guanylate cyclase C agonists and methods of use.
  18. Comiskey, Stephen; Feng, Rong; Foss, John; Shailubhai, Kunwar, Formulations of guanylate cyclase C agonists and methods of use.
  19. Shailubhai, Kunwar; Comiskey, Stephen, Formulations of guanylate cyclase C agonists and methods of use.
  20. Shailubhai, Kunwar; Comiskey, Stephen; Feng, Rong; Bai, Juncai; Zhang, Ruoping; Jia, Jun; Zhou, Junfeng; Zhao, Qiao; Zhang, Guoqing, Ultra-pure agonists of guanylate cyclase C, method of making and using same.
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