[특허]Systems and methods for delivering therapeutic agents

Cook Medical Technologies LLC

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Systems and methods for delivering therapeutic agents

국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61M-001/00
미국특허분류(USC)	604/118;
출원번호	US-0787796 (2010-05-26)
등록번호	US-8118777 (2012-02-21)
발명자 / 주소	Ducharme, Richard W. Sugg, David E. Skelton, Eugene Bruggemann, Martin Bryce, Lyndsey
출원인 / 주소	Cook Medical Technologies LLC
대리인 / 주소	Brinks Hofer Gilson & Lione
인용정보	피인용 횟수 : 1 인용 특허 : 144

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The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. The systems generally comprise a container for holding a therapeutic agent, and a pressure source configured to be placed in selective fluid communication with at least a portion of a reservoir of the container. In one embodiment, fluid from the pressure source is directed through a first region of the container in a direction towards a second region of the container. The fluid then is at least partially redirected to urge the therapeutic agent in a direction from the second region of the container towards the first region of the container and subsequently towards the target site. In alternative embodiments, the fluid from the pressure source may be directed through the second region of the container in a direction towards the first region of the container.

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1. A system suitable for delivering a therapeutic agent to a target site, the system comprising: a container for holding the therapeutic agent, wherein the container comprises first and second regions and has a reservoir containing the therapeutic agent; and a pressure source having pressurized fluid, the pressure source in selective fluid communication with at least a portion of the reservoir of the container; an inlet tube disposed at least partially within the container, and a unitary lumen extending between first and second ends of the inlet tube; and an outlet tube disposed at least partially within the container, and a unitary lumen extending between first and second ends of the outlet tube, wherein fluid from the pressure source is directed through the first region of the container in a direction towards the second region of the container, and wherein the fluid is at least partially redirected to urge the therapeutic agent in a direction from the second region of the container towards the first region of the container and subsequently towards the target site. 2. The system of claim 1 wherein, during use, the first region of the container is disposed vertically above the second region of the container. 3. The system of claim 1 further comprising a cap secured to the first region of the container, the cap having an inlet port and an outlet port, wherein the fluid from the pressure source is directed through the inlet port of the cap, and wherein the fluid is redirected within the container to urge the therapeutic agent through the outlet port of the cap. 4. The system of claim 1 further comprising, wherein the first end of the inlet tube is positioned near the first region of the container and the second end is positioned near the second region of the container, wherein the fluid from the pressure source flows through the inlet tube in the direction from the first region to the second region and into the reservoir of the container. 5. The system of claim 4 wherein the second end of the inlet tube comprises at least a 90 degree curvature to redirect fluid flow in a direction from the second region of the container towards the first region of the container. 6. The system of claim 4 further comprising a u-shaped tube coupled to the second end of the inlet tube, wherein the u-shaped tube is configured to redirect fluid flow in a direction from the second region of the container towards the first region of the container. 7. The system of claim 4 further comprising, wherein fluid exiting the second end of the inlet tube urges the therapeutic agent into the second end of the outlet tube and towards the first end of the outlet tube. 8. The system of claim 7 wherein the second end of the outlet tube is spaced away from the second end of the inlet tube. 9. The system of claim 7 further comprising a flow assembly having an inlet, and outlet, and at least one opening disposed therebetween, wherein the inlet of the flow assembly is coupled to the second end of the inlet tube, the outlet of the flow assembly is coupled to the second end of the inlet tube, and the at least one opening is sized to received the therapeutic agent when fluid passes between the inlet and the outlet of the flow assembly. 10. The system of claim 1 further comprising a platform positioned within the container, the platform forming a substantially fluid tight seal with an inner surface of the container, wherein the therapeutic agent is retained above the platform. 11. The system of claim 10 further comprising, wherein the fluid from the pressure source is directed in a first direction through the inlet tube and through a first opening in the platform; and wherein the fluid is redirected to flow in a second direction through a second opening in the platform and into the reservoir of the container. 12. The system of claim 11 further comprising, wherein fluid exiting the second opening of the platform urges the therapeutic agent into the second end of the outlet tube and towards the first end of the outlet tube. 13. The system of claim 1 further comprising a pressure regulator valve disposed between the pressure source and the container. 14. The system of claim 1 wherein the therapeutic agent comprises a powder.

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Gittard, Shaun D.. Therapeutic agents for delivery using a catheter and pressure source. USP2018019867931.

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Systems and methods for delivering therapeutic agents

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