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Antibodies recognizing a highly expressed putative antigen of CA-MRSA and methods of use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/00
  • A61K-039/38
  • A61K-039/02
  • A61K-039/085
  • A61K-039/09
출원번호 US-0279079 (2007-02-22)
등록번호 US-8124107 (2012-02-28)
국제출원번호 PCT/US2007/004497 (2007-02-22)
§371/§102 date 20081124 (20081124)
국제공개번호 WO2007/100580 (2007-09-07)
발명자 / 주소
  • Hook, Magnus
  • Labandeira-Rey, Maria
  • Bowden, Gabriela M.
출원인 / 주소
  • The Texas A&M University System
대리인 / 주소
    Schulman, Esq., B. Aaron
인용정보 피인용 횟수 : 7  인용 특허 : 23

초록

The present invention provides MSCRAMM® proteins from S. aureus which are putative highly-expressed antigens from methicillin-resistant S. aureus, including communit-associated MRSA (CA-MRSA), and these antigens can thus be utilized in methods of generating antibodies capable of binding these antige

대표청구항

1. An isolated antigen from methicillin-resistant Staphylococcus aureus (MRSA) comprising a protein having the amino acid sequence of SEQ ID NO: 11. 2. A composition comprising the antigen of claim 1 and a pharmaceutically acceptable vehicle, excipient or carrier. 3. A composition comprising an immu

이 특허에 인용된 특허 (23)

  1. Hook Magnus ; Lindberg Kjell Martin,SEX ; Wadstrom Torkel Mikael,SEX, Bacterial cell surface protein with fibronectin, fibrinogen, collagen and laminin binding ability, process for the manu.
  2. Hook Magnus ; Patti Joseph M. ; House-Pompeo Karen ; Sthanam Narayana ; Symersky Jindrich, Collagen binding protein compositions and methods of use.
  3. Foster, Timothy; Roche, Fiona; Pallen, Mark; Patti, Joseph M.; Hutchins, Jeff T.; Speziale, Pietro, Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and Staphylococcus aureus.
  4. Patti, Joseph M.; Foster, Timothy J.; Josefsson, Elisabet; Eidhin, Deidre Ni; Hook, Magnus A. O.; Perkins, Samuel E., Extracellular matrix-binding proteins from staphylococcus aureus.
  5. Hook, Magnus; Patti, Joseph M.; House-Pompeo, Karen L.; Speziale, Pietro; Joh, Danny; McGavin, Martin J., Fibronectin binding protein compositions and methods of use.
  6. Losi Salvatore (Geneva CH) LaLanne Pierre (Gex FR) Henzi Rene (Geneva CH) Marka Erwin (Geneva CH), Gold sulfite baths containing organophosphorous compounds.
  7. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
  8. Patti, Joseph M.; Hutchins, Jeff T.; Domanski, Paul; Patel, Pratiksha; Hall, Andrea, Monoclonal antibodies to the ClfA protein and method of use in treating or preventing infections.
  9. Patti, Joseph M.; Foster, Timothy J.; Hook, Magnus, Multicomponent vaccines.
  10. Patti, Joseph M.; Foster, Timothy J.; Hook, Magnus, Multicomponent vaccines.
  11. Emery, Daryll A.; Straub, Darren E.; Wonderling, Laura; Herron Olson, Lisa L., Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use.
  12. Emery, Daryll A.; Straub, Darren E.; Wonderling, Laura; Herron Olson, Lisa L., Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use.
  13. Foster, Timothy J.; McCrea, Kirk; Hook, Magnus A. O.; Davis, Stacy; Ni Eidhin, Deirdre; Hartford, Orla, Polypeptides and polynucleotides from coagulase-negative staphylococci.
  14. Piasio ; Roger N. ; Ryan ; James W. ; Woiszwillo ; James E., Reverse sandwich immunoassay.
  15. Foster Timothy James,IEX ; McDevitt Damien Leo,IEX, S. aureus fibrinogen binding protein gene.
  16. Foster Timothy James,IEX ; McDevitt Damien Leo,IEX, S. aureusfibrinogen binding protein.
  17. Patti, Joseph M.; Foster, Timothy J.; Josefsson, Elisabet; Eidhin, Deidre Ni; Hook, Magnus A. O.; Perkins, Samuel E., SDRE protein from and diagnostic kits including same.
  18. Patti, Joseph M.; Foster, Timothy J.; Hook, Magnus, Staphylococcal immunotherapeutics via donor selection and donor stimulation.
  19. Patti,Joseph M.; Foster,Timothy J.; Hook,Magnus, Staphylococcal immunotherapeutics via donor selection and donor stimulation.
  20. Kunsch, Charles A.; Choi, Gil A.; Barash, Steven C.; Dillon, Patrick J.; Fannon, Michael R.; Rosen, Craig A., Staphylococcus aureus polynucleotides and sequences.
  21. Kunsch, Charles A.; Choi, Gil H.; Barash, Steven; Dillon, Patrick J.; Fannon, Michael R.; Rosen, Craig A., Staphylococcus aureus polynucleotides and sequences.
  22. Foster, Timothy; Roche, Fiona; Pallen, Mark; Patti, Joseph M.; Hutchins, Jeff T.; Speziale, Pietro, Surface proteins from coagulase-negative staphylococci and .
  23. Foster,Timothy James; McDevitt,Damien Leo, fibrinogen binding protein gene.

이 특허를 인용한 특허 (7)

  1. Ehricht, Ralf; Monecke, Stefan; Rejman, John J.; Buechler, Joseph, Devices and methods for detection of Panton-Valentine Leukocidin (PVL).
  2. Beaumont, Tim; Kwakkenbos, Mark Jeroen; Brown, Eric J.; Morisaki, John Hiroshi; Hazenbos, Wouter L. W.; Mariathasan, Sanjeev; Kajihara, Kimberly; Xia, Yi, Gram-positive bacteria specific binding compounds.
  3. Beaumont, Tim; Kwakkenbos, Mark Jeroen; Brown, Eric J.; Morisaki, John Hiroshi; Hazenbos, Wouter L. W.; Mariathasan, Sanjeev; Kajihara, Kimberly; Xia, Yi, Gram-positive bacteria specific binding compounds.
  4. Beaumont, Tim; Kwakkenbos, Mark Jeroen; Brown, Eric J.; Morisaki, John Hiroshi; Hazenbos, Wouter L. W.; Mariathasan, Sanjeev; Kajihara, Kimberly; Xia, Yi, Gram-positive bacteria specific binding compounds.
  5. Beaumont, Tim; Kwakkenbos, Mark Jeroen; Brown, Eric J.; Morisaki, John Hiroshi; Hazenbos, Wouter L. W.; Mariathasan, Sanjeev; Kajihara, Kimberly; Xia, Yi, Gram-positive bacteria specific binding compounds.
  6. Beaumont, Tim; Kwakkenbos, Mark Jeroen; Brown, Eric J.; Morisaki, John Hiroshi; Hazenbos, Wouter L. W.; Mariathasan, Sanjeev; Kajihara, Kimberly; Xia, Yi, Gram-positive bacteria specific binding compounds.
  7. Beaumont, Tim; Kwakkenbos, Mark Jeroen; Brown, Eric J.; Morisaki, John Hiroshi; Hazenbos, Wouter L. W.; Mariathasan, Sanjeev; Kajihara, Kimberly; Xia, Yi, Gram-positive bacteria specific binding compounds.
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