Silicone acrylate hybride composition and method of making same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/70
C08L-083/10
출원번호
US-0303362
(2007-06-06)
등록번호
US-8124689
(2012-02-28)
국제출원번호
PCT/US2007/013321
(2007-06-06)
§371/§102 date
20081203
(20081203)
국제공개번호
WO2007/145996
(2007-12-21)
발명자
/ 주소
Loubert, Gary
Mitchell, Timothy P.
Thomas, Xavier
출원인 / 주소
Dow Corning Corporation
대리인 / 주소
Howard & Howard Attorneys PLLC
인용정보
피인용 횟수 :
8인용 특허 :
19
초록▼
A silicone acrylate hybrid composition includes the reaction product of a silicon-containing pressure sensitive adhesive composition, an ethylenically unsaturated monomer, and an initiator. The silicon-containing pressure sensitive adhesive composition includes acrylate or methacrylate functionality
A silicone acrylate hybrid composition includes the reaction product of a silicon-containing pressure sensitive adhesive composition, an ethylenically unsaturated monomer, and an initiator. The silicon-containing pressure sensitive adhesive composition includes acrylate or methacrylate functionality. A method of making the hybrid composition includes polymerizing the ethylenically unsaturated monomer and the silicon-containing pressure sensitive adhesive composition in the presence of the initiator.
대표청구항▼
1. A silicone acrylate hybrid composition comprising the reaction product of: A. a silicon-containing pressure sensitive adhesive composition comprising acrylate or methacrylate functionality and the condensation reaction product of; a silicone resin,a silicone polymer, anda silicon-containing cappi
1. A silicone acrylate hybrid composition comprising the reaction product of: A. a silicon-containing pressure sensitive adhesive composition comprising acrylate or methacrylate functionality and the condensation reaction product of; a silicone resin,a silicone polymer, anda silicon-containing capping agent which provides said acrylate or methacrylate functionality, wherein said silicon-containing capping agent is of the general formula XYR′2SiZ wherein X is a monovalent radical of the general formula AE- where E is —O— or —NH— and A is an acryl group or a methacryl group,Y is a divalent alkylene radical having from 1 to 6 carbon atoms,R′ is a methyl or a phenyl radical, andZ is a monovalent hydrolyzable organic radical or a halogen;wherein the silicone resin and silicone polymer are reacted to form a pressure sensitive adhesive, wherein the silicon-containing capping agent is introduced prior to, during, or after the silicone resin and silicone polymer are reacted, and wherein: the silicon-containing capping agent reacts with the pressure sensitive adhesive after the silicone resin and silicone polymer have been condensation reacted to form the pressure sensitive adhesive; orthe silicon-containing capping agent reacts in-situ with the silicone resin and silicone polymer;B. an ethylenically unsaturated monomer; andC. an initiator. 2. A hybrid composition as set forth in claim 1 wherein said ethylenically unsaturated monomer (B) is a compound selected from the group of aliphatic acrylates, aliphatic methacrylates, cycloaliphatic acrylates, cycloaliphatic methacrylates, and combinations thereof, each of said compounds having up to 20 carbon atoms in the alkyl radical. 3. A hybrid composition as set forth in claim 2 wherein said aliphatic acrylates are selected from the group of methyl acrylate, ethyl acrylate, propyl acrylate, n-butyl acrylate, iso-butyl acrylate, tert-butyl acrylate, hexyl acrylate, 2-ethylhexyl acrylate, iso-octyl acrylate, iso-nonyl acrylate, iso-pentyl acrylate, tridecyl acrylate, stearyl acrylate, lauryl acrylate, and combinations thereof, and said aliphatic methacrylates are selected from the group of methyl methacrylate, ethyl methacrylate, propyl methacrylate, n-butyl methacrylate, iso-butyl methacrylate, tert-butyl methacrylate, hexyl methacrylate, 2-ethylhexyl methacrylate, iso-octyl methacrylate, iso-nonyl methacrylate, iso-pentyl methacrylate, tridecyl methacrylate, stearyl methacrylate, lauryl methacrylate, and combinations thereof. 4. A hybrid composition as set forth in claim 1 wherein said silicon-containing pressure sensitive adhesive composition (A) is present in said hybrid composition in an amount of from 5 to 95 parts by weight based on 100 parts by weight of said hybrid composition. 5. A hybrid composition as set forth in claim 1 wherein said ethylenically unsaturated monomer (B) is present in said hybrid composition in an amount of from 5 to 95 parts by weight based on 100 parts by weight of said hybrid composition. 6. A hybrid composition as set forth in claim 1 wherein said initiator (C) is present in said hybrid composition in an amount of from 0.005 to 3 parts by weight based on 100 parts by weight of said hybrid composition. 7. A hybrid composition as set forth in claim 1 wherein said silicon-containing capping agent is selected from the group of acrylate functional silanes, acrylate functional silazanes, acrylate functional disilazanes, acrylate functional disiloxanes, methacrylate functional silanes, methacrylate functional silazanes, methacrylate functional disilazanes, methacrylate functional disiloxanes, and combinations thereof. 8. A hybrid composition as set forth in claim 1 wherein said silicon-containing pressure sensitive adhesive composition comprises a concentration of silicon bonded hydroxyl groups and said silicon-containing capping agent is further defined as an endblocking agent that reacts with said concentration of silicon bonded hydroxyl groups to cap said silicon-containing pressure sensitive adhesive composition. 9. A hybrid composition as set forth in claim 1 wherein said monovalent hydrolyzable organic radical is of the general formula R″O— where R″ is an alkyl radical. 10. A hybrid composition as set forth in claim 1 wherein said endblocking agent is selected from the group of 3-methacryloxypropyldimethylchlorosilane, 3-methacryloxypropyldimethylmethoxysilane, 3-methacryloxypropyldimethylethoxysilane, (methacryloxymethyl)dimethylmethoxysilane, (methacryloxymethyl)dimethylethoxysilane, 3-methacryloxypropyldimethylsilazane, 3-acryloxypropyldimethylchlorosilane, 3-acryloxypropyldimethylmethoxysilane, 3-acryloxypropyldimethylsilazane, and combinations thereof. 11. A hybrid composition as set forth in claim 1 wherein said silicone resin comprises a copolymer comprising triorganosiloxy units of the formula R33SiO1/2 and tetrafunctional siloxy units of the formula SiO4/2 in a ratio of about 0.6 to 0.9 triorganosiloxy units for each tetrafunctional siloxy unit, wherein each R3 independently denotes a monovalent hydrocarbon radical having from 1 to 6 carbon atoms; andsaid silicone polymer comprises at least one polydiorganosiloxane comprising AR3SiO units terminated with endblocking TR3ASiO1/2 units, wherein the polydiorganosiloxane has a viscosity of from about 100 centipoise to about 30,000,000 centipoise at 25° C., each A radical is independently selected from R3 or halohydro-carbon radicals having from 1 to 6 carbon atoms, each T radical is independently selected from the group consisting of R3, OH, H or OR4, and each R4 is independently an alkyl radical having from 1 to 4 carbon atoms. 12. A hybrid composition as set forth in claim 11 wherein, prior to reacting of said silicon-containing capping agent, said silicone resin reacts in an amount of from 30 to 80 parts by weight and said silicone polymer reacts in an amount of from 20 to 70 parts by weight, both based on 100 parts by weight of said silicon-containing pressure sensitive adhesive composition. 13. A silicone acrylate hybrid composition comprising the reaction product of: A. a silicon-containing pressure sensitive adhesive composition comprising acrylate or methacrylate functionality and the condensation reaction product of; a silicone resin,a silicone polymer, anda silicon-containing capping agent which provides said acrylate or methacrylate functionality;B. an ethylenically unsaturated monomer; andC. an initiator;blended with a non-hybrid pressure sensitive adhesive composition selected from the group of silicone pressure sensitive adhesive compositions, acrylic pressure sensitive adhesive compositions, polyurethane pressure sensitive adhesive compositions, natural rubber pressure sensitive adhesive compositions, synthetic rubber pressure sensitive adhesive compositions, and blends thereof. 14. A method of making a silicone acrylate hybrid composition comprising the steps of: providing a silicon-containing pressure sensitive adhesive composition comprising acrylate or methacrylate functionality by condensation reacting a silicone resin, a silicone polymer, and a silicon-containing capping agent which provides the acrylate or methacrylate functionality, wherein said silicon-containing capping agent is of the general formula XYR′2SiZ wherein X is a monovalent radical of the general formula AE- where E is —O— or —NH— and A is an acryl group or a methacryl group,Y is a divalent alkylene radical having from 1 to 6 carbon atoms,R′ is a methyl or a phenyl radical, andZ is a monovalent hydrolyzable organic radical or a halogen;wherein the silicone resin and silicone polymer are reacted to form a pressure sensitive adhesive, wherein the silicon-containing capping agent is introduced prior to, during, or after the silicone resin and silicone polymer are reacted, and wherein: the silicon-containing capping agent reacts with the pressure sensitive adhesive after the silicone resin and silicone polymer have been condensation reacted to form the pressure sensitive adhesive; orthe silicon-containing capping agent reacts in-situ with the silicone resin and silicone polymer; andpolymerizing an ethylenically unsaturated monomer and the silicon-containing pressure sensitive adhesive composition in the presence of an initiator. 15. A method of making a hybrid composition as set forth in 14 wherein the silicon-containing capping agent is reacted after the silicone resin and the silicone polymer have been condensation reacted. 16. A method of making a hybrid composition as set forth in claim 14 wherein the silicon-containing capping agent is reacted in situ with the silicone resin and the silicone polymer as the silicone resin and the silicone polymer are condensation reacting. 17. A method of making a hybrid composition comprising the steps of: providing a silicon-containing pressure sensitive adhesive composition comprising acrylate or methacrylate functionality by condensation reacting a silicone resin, a silicone polymer, and a silicon-containing capping agent which provides the acrylate or methacrylate functionality; andpolymerizing an ethylenically unsaturated monomer and the silicon-containing pressure sensitive adhesive composition in the presence of an initiatorat a temperature of from 50 to 100° C. 18. A method of making a hybrid composition as set forth in claim 14 further comprising the step of mixing the silicon-containing pressure sensitive adhesive composition, the ethylenically unsaturated monomer, and the initiator to form a pre-reaction mixture prior to said step of polymerizing. 19. A transdermal drug delivery system comprising: I. an active agent for controlled transdermal delivery to a substrate; andII. a silicone acrylate hybrid composition for maintaining contact with the substrate, said hybrid composition comprising the reaction product of: A. a silicon-containing pressure sensitive adhesive composition comprising acrylate or methacrylate functionality and the condensation reaction product of: a silicone resin,a silicone polymer, anda silicon-containing capping agent which provides said acrylate or methacrylate functionality;B. an ethylenically unsaturated monomer; andC. an initiator. 20. A system as set forth in claim 19 wherein said active agent is selected from the group of cardioactive medications, androgenic steroids, estrogens, hormones, external analgesics, progestational agents, drugs having an action on the central nervous system, nutritional agents, anti-inflammatory agents, antihistamines, respiratory agents, sympathomimetics, miotics, cholinergic agonists, antimuscarinic or muscarinic cholinergic blocking agents, mydriatics, psychicenergizers, anti-infectives, dermatological agents, humoral agents, antispasmodics, antidepressant drugs, anti-diabetic, anorectic drugs, anti-allergenics, tranquilizers, antipsychotics, decongestants, antipyretics, antimigrane agents, drugs for treating nausea and vomiting, anti-malarials, anti-ulcerative agents, peptides, drugs for Parkinson's disease, drugs for spasticity, drugs for acute muscle spasms, anti-estrogen, anti-hormone agents, therapeutic agents, and combinations thereof. 21. A system as set forth in claim 19 wherein said active agent is disposed in said hybrid composition for the controlled transdermal delivery to the substrate. 22. A system as set forth in claim 19 wherein said active agent and said hybrid composition coexist in said system in discrete layers. 23. A system as set forth in claim 19 further comprising; a backing layer for supporting said hybrid composition; and/ora release liner for protecting said hybrid composition and/or said active agent prior to the controlled transdermal delivery to a substrate. 24. A system as set forth in claim 19 selected from the group of patches, films, multi-layer dressings, reservoir systems, and combinations thereof.
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