Medical radioisotopes and methods for producing the same
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01J-019/08
C01G-039/00
G21G-001/00
G21G-001/04
G21G-001/10
출원번호
US-0659394
(2005-08-02)
등록번호
US-8126104
(2012-02-28)
국제출원번호
PCT/US2005/027558
(2005-08-02)
§371/§102 date
20081002
(20081002)
국제공개번호
WO2006/028620
(2006-03-16)
발명자
/ 주소
Schenter, Robert E.
Wester, Dennis W.
Hollenberg, Glenn W.
Rapko, Brian M.
Lumetta, Gregg J.
출원인 / 주소
Battelle Memorial Institute
대리인 / 주소
Klarquist Sparkman, LLP
인용정보
피인용 횟수 :
5인용 특허 :
29
초록▼
This disclosure concerns a new method for preparing radioisotopes, such as molybdenum-99, by alpha particle irradiation, such as by alpha particle irradiation of zirconium-96. Molybdenum-99 is a precursor to the medically-significant radioisotope technetium-99m. Also disclosed are novel compositions
This disclosure concerns a new method for preparing radioisotopes, such as molybdenum-99, by alpha particle irradiation, such as by alpha particle irradiation of zirconium-96. Molybdenum-99 is a precursor to the medically-significant radioisotope technetium-99m. Also disclosed are novel compositions containing one or more of technetium-99m, molybdenum-99 and zirconium species. Systems for producing molybdenum-99 and technetium-99m, including alpha particle generators and irradiation targets, also are described.
대표청구항▼
1. A process for producing molybdenum-99, comprising: irradiating at least a portion of a zirconium target with alpha particles, thereby producing an irradiated target portion comprising molybdenum-99; andseparating the molybdenum-99 from other target species, wherein the irradiating and the separat
1. A process for producing molybdenum-99, comprising: irradiating at least a portion of a zirconium target with alpha particles, thereby producing an irradiated target portion comprising molybdenum-99; andseparating the molybdenum-99 from other target species, wherein the irradiating and the separating occur simultaneously. 2. The process according to claim 1, wherein separating comprises chemical separation. 3. The process according to claim 1, wherein separating comprises mass difference separation. 4. The process according to claim 3, wherein the mass difference separation comprises plasma separation. 5. The process according to claim 1, wherein the irradiating at least a portion of the target includes exposing the target to an alpha particle beam having a flux of at least about 1016 α/(cm2)s. 6. The process according to claim 1, wherein the target comprises at least about 10% zirconium-96. 7. The process according to claim 1, further comprising purifying the molybdenum-99 to produce purified molybdenum-99. 8. The process according to claim 7, further comprising loading the purified molybdenum-99 onto an adsorbent column. 9. The process according to claim 8, further comprising allowing at least a portion of the purified molybdenum-99 to decay to technetium-99m. 10. The process according to claim 9, further comprising eluting the technetium-99m from the adsorbent column. 11. The process according to claim 1, further comprising producing technetium-99m from the molybdenum-99. 12. A process for producing molybdenum-99, comprising: irradiating a first location of a zirconium target with alpha particles, thereby producing first irradiated target material comprising molybdenum-99, while simultaneously removing second irradiated target material from a second location of the target. 13. The process according to claim 12, wherein removing comprises contacting the second irradiated target material with a solvent, thereby producing an irradiated target solution. 14. The process according to claim 13, wherein the solvent is aqua regia. 15. The process according to claim 14, further comprising adjusting the concentration of the irradiated target solution to a chloride molarity of from about 4 to about 8 and subjecting the solution to ion-exchange chromatography. 16. The process according to claim 14, further comprising evaporating the aqua regia, thereby yielding a residue comprising zirconium and molybdenum-99. 17. The process according to claim 16, further comprising contacting the residue with an alkaline solution to selectively dissolve molybdenum species. 18. The process according to claim 12, wherein removing the second irradiated target material from the target comprises sputtering. 19. The process according to claim 18, wherein sputtering employs a focused ion beam. 20. The process according to claim 12, wherein removing the second irradiated target material from the target comprises mechanical milling. 21. The process according to claim 12, wherein removing and irradiating are performed in a continuous process. 22. The process according to claim 12, wherein alpha particles are within an alpha beam, and further comprising optimizing an energy of the alpha beam using alpha transport theory so as to maximize the production of molybdenum-99 and minimize the production of other products. 23. The process according to claim 12, further comprising producing technetium-99m from the molybdenum-99. 24. A process for producing molybdenum-99, comprising: irradiating a zirconium target with alpha particles while contacting the irradiated target with a fluorinating agent; andcontinuously adjusting the target such that different portions of the target are irradiated by alpha particles and contacted with the fluorinating agent,wherein the continuously adjusting occurs while continuously removing at least some irradiated target material from the target. 25. The process according to claim 24, wherein contacting the irradiated target with the fluorinating agent produces fluoride species comprising MoF5, MoF6 or both. 26. The process according to claim 25, wherein the fluorinating agent comprises at least one of NF3 and HF. 27. The process according to claim 25, wherein contacting the irradiated target with the fluorinating agent comprises activating the fluorinating agent with microwave radiation. 28. The process according to claim 24, further comprising producing technetium-99m from the molybdenum-99. 29. A process for producing molybdenum-99, comprising: positioning a zirconium target such that a portion of the target is irradiated by alpha particles from an alpha particle source, thereby producing irradiated target material comprising molybdenum-99; andcontinuously adjusting the target, the alpha particle source, or both the target and the alpha particle source such that a different portion of the target is irradiated by alpha particles,wherein the continuously adjusting occurs while continuously removing at least some of the irradiated target material from the target. 30. The process according to claim 29, further comprising purifying molybdenum-99 from the irradiated target material. 31. The process according to claim 30, wherein purifying molybdenum-99 comprises ion-exchange chromatography. 32. The process according to claim 30, wherein purifying molybdenum-99 comprises selectively dissolving molybdenum-99 in a solvent. 33. The process according to claim 30, wherein purifying molybdenum-99 comprises forming a molybdenum fluoride. 34. The process according to claim 29, further comprising producing technetium-99m from the molybdenum-99. 35. The process according to claim 29, wherein the continuously adjusting comprises moving the target in a cyclical pattern such that the removing exposes non-irradiated target material that is subsequently irradiated by the alpha particles. 36. The process according to claim 35, wherein the target comprises a rotating disk. 37. The process according to claim 35, wherein the target comprises a thin strip circulating in a loop.
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이 특허에 인용된 특허 (29)
Peterson Steven H. (Murrysville PA) Phillips D. Colin (Monroeville PA), Chemical separation method for uranium isotopes.
McIntyre, Raymond D; Johnsen, Stanley W; Marc, Marcel; Delfino, Michelangelo; Seppi, Edward, Method and apparatus for producing radioactive materials for medical treatment using x-rays produced by an electron accelerator.
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