초록 ▼

A system and method for predicting the onset of glaucoma uses a Finite Element Model (FEM) to obtain a response profile of the Optical Nerve Head (ONH) inside an eye. To do this, the FEM is programmed with data from first and second images of the ONH that are respectively taken at the beginning and

A system and method for predicting the onset of glaucoma uses a Finite Element Model (FEM) to obtain a response profile of the Optical Nerve Head (ONH) inside an eye. To do this, the FEM is programmed with data from first and second images of the ONH that are respectively taken at the beginning and the end of an imposed pressure differential (e.g. over a range of about 8 kPa). The FEM is then subjected to a sequence of pressure increments and the resultant profile is compared with empirical data to predict an onset of glaucoma.

대표청구항 ▼

1. A method for determining an onset of glaucoma in an eye which comprises the steps of: providing a programmable Finite Element Model (FEM) of an Optical Nerve Head (ONH) of a patient having elements with tensor parameters respectively representative of a Lamina Cribrosa (LC), Prelaminar Neural Tis

1. A method for determining an onset of glaucoma in an eye which comprises the steps of: providing a programmable Finite Element Model (FEM) of an Optical Nerve Head (ONH) of a patient having elements with tensor parameters respectively representative of a Lamina Cribrosa (LC), Prelaminar Neural Tissue (PrNT), Postlaminar Neural Tissue (PoNT), and Sclera;measuring data of stress-strain characteristics for tissue at each of a plurality of locations in the ONH of the patient in response to a predetermined pressure differential, wherein each location corresponds to a respective element of the FEM;entering the data into the FEM;varying the tensor parameters of the FEM to obtain a patient-specific pressure response profile for the ONH of the patient; andusing a computer to evaluate the profile in comparison with an empirical statistic to predict the onset of glaucoma. 2. A method as recited in claim 1 wherein the measuring step further comprises the steps of: creating a first image of the ONH of the patient at a first pressure;creating a second image of the ONH of the patient at a second pressure; andassessing the first image and the second image to establish the data. 3. A method as recited in claim 2 wherein the predetermined pressure differential is approximately 8 kPa. 4. A method as recited in claim 2 wherein the first pressure is approximately 2 kPa, and the second pressure is approximately 8 kPa. 5. A method as recited in claim 1 wherein the varying step is accomplished relative to a base condition to simulate a change of pressure in the eye of the patient through a range of about 8 kPa. 6. A method as recited in claim 5 wherein the change of pressure is accomplished in pressure increments, wherein each pressure increment is equal to approximately 1 kPa. 7. A method as recited in claim 1 wherein the FEM substantially replicates a cylindrical shaped body having a first end surface and a second end surface with a cylindrical surface therebetween, and further wherein elements of the FEM representing the PrNT are arranged on the first end surface, wherein elements of the FEM representing the PoNT are arranged on the second end surface, wherein elements of the FEM representing the LC are located between the first end surface and the second end surface, and wherein elements of the FEM representing the sclera are arranged on the cylindrical surface. 8. A method as recited in claim 7 wherein the elements of the FEM representing the sclera include a plurality of fiber elements, with the fiber elements transitioning in an outward direction from the cylindrical surface, with the transition being characterized by a change from a substantially circumferential orientation at the cylindrical surface to an increasingly spiral orientation with increasing distance from the cylindrical surface to add stability to the FEM. 9. A method as recited in claim 8 wherein the elements of the FEM representing the LC include simulated pores, wherein a location and a size for each pore is determined by Second Harmonic Generation (SHG) imaging of the ONH.