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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0650065 (2009-12-30) |
등록번호 | US-8148164 (2012-04-03) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 4 인용 특허 : 537 |
The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about
The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 2.0 seconds or less, and/or having a clinically low Total System Error.
1. A method for determining a concentration of a medically significant component of a biological fluid in contact with a reagent compound, comprising the steps of: a) applying a first signal having an AC component to the biological fluid;b) measuring a first response to the first signal;c) applying
1. A method for determining a concentration of a medically significant component of a biological fluid in contact with a reagent compound, comprising the steps of: a) applying a first signal having an AC component to the biological fluid;b) measuring a first response to the first signal;c) applying a second signal to the biological fluid, wherein the second signal is a DC signal;d) measuring a second response to the second signal; ande) combining the first response with the second response to produce an indication of the concentration of the medically significant component; wherein said first signal comprises a multi-frequency excitation waveform formed by adding a plurality of individual waveforms of varying frequency together so that the fluid sample is excited by multiple frequencies at the same time such that the first response contains measurement data collected simultaneously for all of the multiple frequencies. 2. The method according to claim 1, wherein the first response comprises admittance data corresponding to each frequency of the multi-frequency excitation waveform, the second response comprises an uncorrected response of the medically significant component predicted with the DC signal, and wherein combining the first response with the second response comprises an algorithmic combination of the admittance data and the uncorrected response to calculate a predicted concentration of the medically significant component in the biological fluid. 3. The method according to claim 2, wherein the medically significant component comprises glucose and the biological fluid comprises blood. 4. The method according to claim 1, wherein combining the first response with the second response comprises the steps of determining an interferent correction from the first response, determining an indicated concentration from the second response, and correcting the indicated concentration using the interferent correction. 5. The method according to claim 4, wherein the medically significant component comprises glucose, the biological fluid comprises blood, and the first response comprises information pertaining substantially only to one or both of hematocrit and temperature. 6. The method according to claim 1, wherein the total time from applying the first signal to measuring the second response is within about 2.0 seconds. 7. The method according to claim 1, wherein the method has a Total System Error of less than about 15%. 8. The method according to claim 1, wherein the multi-frequency excitation waveform comprises at least two frequencies selected from the group consisting of about 1 kHz, about 2 kHz, about 10 kHz and about 20 kHz. 9. The method according to claim 8, wherein measuring the first response comprises measuring one or both of admittance and phase information corresponding to each of the frequencies comprising the multi-frequency excitation waveform generally simultaneously. 10. The method according to claim 9, wherein measuring the second response occurs within about 1000 ms or less after the measuring the first response. 11. The method of claim 6, wherein the determination has a Total Test Time of between about 0.5 seconds and about 1,525 seconds, and wherein the method has a Total System Error of less than about 11%.
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