초록 ▼

Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting b

Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.

대표청구항 ▼

1. An osteogenic implant for promoting bone growth between first and second bone surfaces, comprising: a first resorbable implant material defining an implant body configured for receipt between the first and second bone surfaces, said first resorbable implant material comprising a porous collagenou

1. An osteogenic implant for promoting bone growth between first and second bone surfaces, comprising: a first resorbable implant material defining an implant body configured for receipt between the first and second bone surfaces, said first resorbable implant material comprising a porous collagenous matrix containing mineral particles, said implant body having an outer surface; the first resorbable implant material being substantially free of an osteogenic protein;a second resorbable implant material comprising a collagen sponge sheet wrapped around at least a portion of said outer surface of said implant body and positioned to contact said first and second bone surfaces; andan osteogenic protein carried by said second resorbable implant material. 2. The osteogenic implant of claim 1, wherein: said osteogenic protein is a bone morphogenic protein (BMP). 3. The osteogenic implant of claim 2, wherein: said BMP is BMP-2 or BMP-7. 4. The osteogenic implant of claim 1, wherein: said osteogenic protein is BMP-2. 5. The osteogenic implant of claim 4, wherein: said BMP-2 is recombinant human BMP-2. 6. The osteogenic implant of claim 1, wherein: said mineral particles comprise bone. 7. The osteogenic implant of claim 1, wherein: said mineral particles comprise synthetic ceramic. 8. The osteogenic implant of claim 7, wherein: (i) said synthetic ceramic comprises tricalcium phosphate or (ii) said synthetic ceramic comprises biphasic calcium phosphate. 9. The osteogenic implant of claim 8, wherein: said biphasic calcium phosphate has a weight ratio of tricalcium phosphate to hydroxyapatite of about 50:50 to about 95:5. 10. The osteogenic implant of claim 9, wherein: said ratio of tricalcium phosphate to hydroxyapatite is about 80:20 to about 90:10. 11. The osteogenic implant of claim 10, wherein: said ratio of tricalcium phosphate to hydroxyapatite is about 85:15. 12. An implant configured to promote posterolateral spinal fusion between first and second transverse processes in a patient, comprising: a first resorbable implant material configured for receipt between the first and second transverse processes, said first resorbable implant material comprising mineral particles, said implant material having an outer surface;a collagen sponge sheet wrapped around at least a portion of said outer surface of said implant body and positioned to contact the first and second transverse processes;and a bone morphogenic protein (BMP) incorporated in said collagen sponge sheet. 13. The implant of claim 12, wherein: said collagen sponge sheet comprises the BMP at a concentration of about 0.6 mg/cc to about 4 mg/cc; and at least a portion of said implant material is essentially free from said BMP. 14. An implant for promoting bone growth, comprising: a first bioresorbable implant material comprising a mineral and configured to occupy a volume for bone ingrowth; anda second bioresorbable implant material comprising a porous collagen sponge sheet wrapped around at least a portion of said first implant material; said implant comprising an osteogenic factor. 15. The implant of claim 14, wherein: the osteogenic factor is BMP-2 and the mineral comprises tricalcium phosphate and hydroxyapatite in a ratio of about 85:15. 16. The implant of claim 14, wherein the first bioresorbable implant material is a ceramic block.