IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0337882
(2008-12-18)
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등록번호 |
US-8152908
(2012-04-10)
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발명자
/ 주소 |
- Masel, Richard I.
- Radadia, Adarsh D.
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출원인 / 주소 |
- The Board of Trustees of the University of Illinois
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대리인 / 주소 |
Kilpatrick Townsend & Stockton LLP
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인용정보 |
피인용 횟수 :
1 인용 특허 :
167 |
초록
▼
Improved microcolumns and methods for producing microcolumns particularly suitable for use in gas chromatographs are disclosed. In particular, following deposition of the stationary phase coating, the microcolumns are subjected to a postcoating treatment with a molecule that binds to the active site
Improved microcolumns and methods for producing microcolumns particularly suitable for use in gas chromatographs are disclosed. In particular, following deposition of the stationary phase coating, the microcolumns are subjected to a postcoating treatment with a molecule that binds to the active sites in the stationary phase column thereby eliminating or reducing loss of gas chromatograph performance associated with those active sites. The postcoating treatment molecule binds to the same active sites as the analytes of interest.
대표청구항
▼
1. A Gas chromatography (GC) column, comprising: a plurality of column walls each having a deactivated inner surface;a stationary phase layer deposited on the deactivated inner surface of said plurality of column walls;a plurality of binding sites in said stationary phase layer; anda post-coating mo
1. A Gas chromatography (GC) column, comprising: a plurality of column walls each having a deactivated inner surface;a stationary phase layer deposited on the deactivated inner surface of said plurality of column walls;a plurality of binding sites in said stationary phase layer; anda post-coating molecule bound to at least one of said plurality of binding sites in said stationary phase layer;wherein the post-coating molecule is one or more compounds selected from the group consisting of a thiol, a phosphine, an amine, wherein R and R′ are linear, branched, or substituted hydrocarbons. 2. The GC column of claim 1, wherein the inner surface of said plurality of column walls has been deactivated with a compound selected from the group consisting of DMDCS, Ah3P, and DPTMDS. 3. The GC column of claim 1, wherein said stationary phase layer has a thickness of about 0.1 μM. 4. The GC column of claim 1, wherein said stationary phase layer is uniformly spread over the inner surface of said plurality of column walls. 5. The GC column of claim 1, wherein said plurality of column walls has a serpentine configuration. 6. The GC column of claim 1, wherein said plurality of column walls are rounded. 7. The GC column of claim 1, wherein said post-coating molecule comprises a structure of Formula I: where R and R′ are linear, branched, or substituted hydrocarbons. 8. The GC column of claim 1, wherein the post-coating molecule comprises the structure of Formula II: 9. A method for preparing a gas chromatograph (GC) column, said method comprising the steps of deactivating a plurality of walls of a GC column;depositing a stationary phase in the GC column; andtreating the GC column with a molecule such that the molecule binds to active sites in the stationary phase of the column;wherein the molecule is one or more compounds selected from the group consisting of an acid including hydrocarbon ligands, a base including hydrocarbon ligands, a thiol, a phosphine, and an amine. 10. The method of claim 9, wherein the stationary phase in said depositing step is applied at a pressure of about 0.9 psi and at a concentration of about 10 w/v %. 11. The method of claim 9, wherein the deactivating step comprises a method selected from the group consisting of silylation, perisilylation, and deactivation using an organosilicon hydride. 12. The method of claim 11, wherein the silylation is performed using DMDCS, the perisilylation is performed using Ah3P, and the deactivation with the organosilicon hydride is performed using DPTMDS. 13. The method of claim 9, wherein the molecule in said treating step comprises a structure of Formula I: where R and R′ are linear, branched, or substituted hydrocarbons. 14. The method of claim 13, wherein the molecule comprises the structure of Formula II: 15. A gas chromatograph (GC) column prepared by the method of claim 9. 16. The GC column of claim 15, wherein the molecule in said treating step comprises a structure of Formula I: where R and R′ are linear, branched, or substituted hydrocarbons. 17. The GC column of claim 15, wherein the molecule comprises the structure of Formula II: 18. The GC column of claim 15, wherein the molecule comprises the structure of Formula III: where R and R′ are linear, branched, or substituted hydrocarbons.
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