초록 ▼

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices incl

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

대표청구항 ▼

1. An implantable device for measuring an analyte, the device comprising: a sensor body comprising a sensor configured to measure an analyte; anda composite bilayer membrane comprising an angiogenic material configured to promote angiogenesis and a bioprotective membrane disposed on at least a porti

1. An implantable device for measuring an analyte, the device comprising: a sensor body comprising a sensor configured to measure an analyte; anda composite bilayer membrane comprising an angiogenic material configured to promote angiogenesis and a bioprotective membrane disposed on at least a portion of the sensor, wherein the bioprotective membrane comprises polycarbonate urethane and polyvinylpyrrolidone, and wherein the angiogenic material is adjacent to the bioprotective membrane. 2. The device of claim 1, wherein the bioprotective membrane comprises pores having pore sizes of from about 0.1 micron to about 1 micron. 3. The device of claim 1, wherein the bioprotective membrane further comprises at least one material selected from the group consisting of polytetrafluoroethylene, polypropylene, polysulfone, and polyethylene terephthalate. 4. The device of claim 1, wherein the angiogenic material comprises expanded polytetrafluoroethylene.