IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0070332
(2008-02-15)
|
등록번호 |
US-8165668
(2012-04-24)
|
발명자
/ 주소 |
- Dacey, Jr., Ralph G.
- Della Rocca, Gregory J.
- Derdeyn, Colin P.
- Dowling, Joshua L.
- Goodall, Eleanor V.
- Hyde, Roderick A.
- Ishikawa, Muriel Y.
- Kare, Jordin T.
- Leuthardt, Eric C.
- Myhrvold, Nathan P.
- Smith, Michael A.
- Wood, Jr., Lowell L.
- Wood, Victoria Y. H.
- Zipfel, Gregory J.
|
출원인 / 주소 |
- The Invention Science Fund I, LLC
|
인용정보 |
피인용 횟수 :
27 인용 특허 :
127 |
초록
▼
Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with magnetic stimuli are disclosed. Methods and systems for reversing effects of blocking stimuli and/or for producing substantially permanent conduction block are also dis
Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with magnetic stimuli are disclosed. Methods and systems for reversing effects of blocking stimuli and/or for producing substantially permanent conduction block are also disclosed.
대표청구항
▼
1. A method of modulating neural activity comprising the steps of: producing a reversible conduction block in a peripheral neural structure of a subject with a magnetic field blocking stimulus while the subject is in a low activity state;reversing the reversible conduction block in the peripheral ne
1. A method of modulating neural activity comprising the steps of: producing a reversible conduction block in a peripheral neural structure of a subject with a magnetic field blocking stimulus while the subject is in a low activity state;reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a higher activity state; andrepeating the steps of producing a reversible conduction block in a peripheral neural structure of a subject with a magnetic field blocking stimulus while the subject is in a low activity state and reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a higher activity state. 2. The method of claim 1, wherein the activity of the subject includes the overall activity of the subject. 3. The method of claim 1, wherein the activity of the subject includes use of a body portion innervated by the peripheral neural structure by the subject. 4. The method of claim 1, wherein producing a reversible conduction block in a peripheral neural structure of a subject includes producing a reversible conduction block in a sensory-motor nerve of a subject. 5. The method of claim 1, wherein producing a reversible conduction block in a peripheral neural structure of a subject includes producing a reversible conduction block in an autonomic nerve of a subject. 6. The method of claim 1, wherein producing a reversible conduction block in a peripheral neural structure of a subject includes producing a reversible conduction block in a peripheral nerve of a subject. 7. The method of claim 6, wherein producing a reversible conduction block in a peripheral nerve of a subject includes producing a reversible conduction block in at least one of a radial nerve, a median nerve, an ulnar nerve, a femoral nerve, an obturator nerve, a sciatic nerve, a popliteal nerve, a tibial nerve, a peroneal nerve, or a vagus nerve of a subject. 8. The method of claim 1, further comprising: receiving an input indicative of an activity state of the subject, wherein the input is indicative of at least one of a low activity state and a higher activity state of the subject. 9. The method of claim 8, wherein receiving an input indicative of an activity state of the subject includes receiving an input representing physiological activity of the subject. 10. The method of claim 9, wherein receiving an input representing physiological activity of the subject includes receiving an input representing at least one of heart rate of the subject, respiration, brain activity, peripheral neural activity, muscle activity, or body temperature of the subject. 11. The method of claim 8, wherein receiving an input indicative of an activity state of the subject includes receiving an input representative of physical activity of the subject. 12. The method of claim 11, wherein receiving an input representative of physical activity of the subject includes receiving an input representative of at least one of motion, body position, or posture of the subject. 13. The method of claim 11, wherein receiving an input representative of physical activity of the subject includes receiving an input from at least one of a pressure sensor, a force sensor, an accelerometer, a gyro, a switch, or a piezoelectric device. 14. The method of claim 8, wherein receiving an input indicative of an activity state of the subject includes receiving an input representing rest or waking state of the subject. 15. The method of claim 1, including receiving an input indicative of a user instruction. 16. The method of claim 15, wherein receiving an input indicative of a user instruction includes receiving an input from a user-controlled intermediate device. 17. The method of claim 15, wherein receiving an input indicative of a user instruction includes receiving a signal from a user input device. 18. The method of claim 17, wherein receiving a signal from a user input device includes receiving a signal from at least one of a sound-activated input device, a user-activated switch, a pointing device, a touch screen, or a keyboard. 19. The method of claim 15, wherein receiving an input indicative of a user instruction includes receiving an input indicative of an instruction to modify at least one of the definition of the low activity state or the definition of the higher activity state. 20. The method of claim 1, wherein producing a reversible conduction block in a peripheral neural structure of a subject while the subject is in a first activity state includes producing a reversible conduction block in a peripheral neural structure of a subject with a blocking stimulus source worn on the body of the subject. 21. The method of claim 20, wherein producing a reversible conduction block in a peripheral neural structure of a subject while the subject is in a low activity state includes producing a reversible conduction block in a peripheral neural structure of a subject with a blocking stimulus source located in or on at least one of a wrap adapted to be positioned around at least a portion of the body of the subject, a bracelet configured to be worn on a limb of the subject, an anklet configured to be worn on a limb of the subject, a cuff configured to be worn on a limb of the subject, a collar configured to be worn on a neck of the subject, or necklace configured to be worn on a neck of the subject. 22. The method of claim 1, wherein producing a reversible conduction block in a peripheral neural structure of a subject while the subject is in a low activity state includes producing a reversible conduction block in a peripheral neural structure of a subject with a blocking stimulus source configured to be positioned beneath at least a portion of the body of the subject. 23. The method of claim 22, wherein producing a reversible conduction block in a peripheral neural structure of a subject while the subject is in a low activity state includes producing a reversible conduction block in a peripheral neural structure of a subject with a blocking stimulus source located in or on at least one of a chair, a bed, a pad, or cushion. 24. The method of claim 1, wherein producing a reversible conduction block in a peripheral neural structure of a subject while the subject is in a low activity state includes producing a reversible conduction block in a peripheral neural structure of a subject with a blocking stimulus source implanted within the body of the subject. 25. The method of claim 1, wherein producing a reversible conduction block includes applying a magnetic field to at least a portion of the peripheral neural structure. 26. The method of claim 25, wherein producing a reversible conduction block includes applying at least one of a pulsed magnetic field, an oscillating magnetic field, a cyclical magnetic field, a periodic magnetic field, or a time-varying magnetic field to at least a portion of the peripheral neural structure. 27. The method of claim 1, including reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a higher activity state by removing the magnetic field blocking stimulus used to produce the reversible conduction block in the peripheral neural structure of the subject. 28. The method of claim 1, wherein reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a higher activity state by applying a reversing stimulus configured to counter the magnetic field blocking stimulus used to produce the reversible conduction block in the peripheral neural structure of the subject. 29. The method of claim 28, wherein applying a reversing stimulus to counter the magnetic field blocking stimulus used to produce the reversible conduction block in the peripheral neural structure of the subject includes applying an electric field to at least a portion of the peripheral neural structure. 30. The method of claim 28, wherein applying a reversing stimulus to counter the blocking stimulus used to produce the reversible conduction block in the peripheral neural structure of the subject includes applying at least one of a pulsed electric field, a cyclical electric field, or a time-varying electric field to at least a portion of the peripheral neural structure. 31. The method of claim 28, wherein applying a reversing stimulus to counter the blocking stimulus used to produce the reversible conduction block in the peripheral neural structure of the subject includes applying at least one of a magnetic field, a pulsed magnetic field, or electromagnetic energy to at least a portion of the peripheral neural structure. 32. The method of claim 28, wherein applying a reversing stimulus to counter the blocking stimulus used to produce the reversible conduction block in the peripheral neural structure of the subject includes at least one of heating or cooling at least a portion of the peripheral neural structure. 33. The method of claim 1, further comprising: determining that producing the reversible conduction block in the peripheral neural structure of the subject with a magnetic field blocking stimulus while the subject is in a low activity state results in a desired effect in the subject; andproducing a non-reversible conduction block in the peripheral neural structure of the subject. 34. The method of claim 33, including: producing a non-reversible conduction block by applying heat to at least a portion of the peripheral neural structure of the subject. 35. The method of claim 1, wherein producing a reversible conduction block in a peripheral neural structure of a subject with a magnetic field blocking stimulus while the subject is in a low activity state includes producing a reversible conduction block of a subset of nerve fibers in the peripheral neural structure of the subject with a magnetic field while the subject is in the low activity state;reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a higher activity state includes reversing the reversible conduction block of the subset of nerve fibers in the peripheral neural structure of the subject to permit conduction in the subset of nerve fibers in the peripheral neural structure when the subject is in the higher activity state. 36. The method of claim 35, wherein the subset of nerve fibers in the peripheral neural structure of the subject includes at least one of nerve fibers within a selected diameter range, nerve fibers within a selected spatial distribution within the peripheral neural structure, nerve fibers within selected fascicles within the peripheral neural structure, or nerve fibers including a selected molecular feature. 37. The method of claim 33, including: producing a non-reversible conduction block by removing heat from at least a portion of the peripheral neural structure of the subject. 38. The method of claim 33, wherein producing a non-reversible conduction block includes producing substantially complete blockage of conduction in the peripheral neural structure of the subject. 39. The method of claim 33, including: producing a non-reversible conduction block by at least one of applying an electrical current to at least a portion of the peripheral neural structure of the subject, delivering acoustic energy to at least a portion of the peripheral neural structure of the subject, delivering photons to at least a portion of the peripheral neural structure of the subject, delivering a chemical agent to at least a portion of the peripheral neural structure of the subject, or surgical transection of at least a portion of the peripheral neural structure of the subject. 40. The method of claim 1, wherein the steps of producing a reversible conduction block in a peripheral neural structure of a subject while the subject is in a low activity state and reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a higher activity state occur over a period of time sufficient to produce a modulation of at least one of an immune response an inflammatory response in a region innervated by the peripheral neural structure. 41. The method of claim 1, wherein producing a reversible conduction block in a peripheral neural structure of a subject includes producing a reversible conduction block in at least one of a spinal root, a geniculate ganglion, an autonomic ganglion, or a nerve plexus of a subject. 42. The method of claim 1, including at least one of storing information regarding an activity state of the subject, storing information regarding producing the reversible conduction block, transmitting information regarding an activity state of the subject, or transmitting information regarding producing the reversible conduction block.
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