IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0070331
(2008-02-15)
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등록번호 |
US-8170658
(2012-05-01)
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발명자
/ 주소 |
- Dacey, Jr., Ralph G.
- Della Rocca, Gregory J.
- Derdeyn, Colin P.
- Dowling, Joshua L.
- Goodall, Eleanor V.
- Hyde, Roderick A.
- Ishikawa, Muriel Y.
- Kare, Jordin T.
- Leuthardt, Eric C.
- Myhrvold, Nathan P.
- Smith, Michael A.
- Wood, Jr., Lowell L.
- Wood, Victoria Y.H.
- Zipfel, Gregory J.
|
출원인 / 주소 |
- The Invention Science Fund I, LLC
|
인용정보 |
피인용 횟수 :
9 인용 특허 :
127 |
초록
▼
Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with electrical stimuli are disclosed. Methods and systems for reversing effects of blocking stimuli and/or for producing substantially permanent conduction block are also d
Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with electrical stimuli are disclosed. Methods and systems for reversing effects of blocking stimuli and/or for producing substantially permanent conduction block are also disclosed.
대표청구항
▼
1. A neural modulation system comprising: a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;a signal processing portion configured to: distinguish a low activity state of th
1. A neural modulation system comprising: a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;a signal processing portion configured to: distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; andgenerate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state; anda blocking stimulus source configured to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal. 2. The neural modulation system of claim 1, including a sensor operatively connected to the signal input structure and configured to generate the signal indicative of the activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure responsive to an activity of the at least a portion of the body of the subject. 3. The neural modulation system of claim 1, wherein the blocking stimulus source includes an electrical field source. 4. The neural modulation system of claim 1, wherein the signal processing portion is configured to: determine the onset of the low activity state; andgenerate the blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject at least intermittently responsive to detecting the onset of a low activity state in the subject. 5. The neural modulation system of claim 4, wherein the signal processing portion is configured to generate the blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject substantially immediately upon detecting the onset of the low activity state in the subject. 6. The neural modulation system of claim 4, wherein the signal processing portion is configured to generate the blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject at a delay interval after detecting the onset of the low activity state in the subject. 7. The neural modulation system of claim 4, wherein the signal processing portion is configured to: initiate a release period during which no blocking stimulus control signal is generated after an interval determined relative to the onset of generation of the blocking stimulus control signal. 8. The neural modulation system of claim 1, wherein the signal processing portion is configured to: predict the onset of the higher activity state in the subject; andinitiate a release period during which no blocking stimulus control signal is generated responsive to the predicted onset of the higher activity state in the subject. 9. The neural modulation system of claim 8, wherein the signal processing portion is configured to: initiate the release period at an interval prior to the predicted onset of the higher activity state in the subject. 10. The neural modulation system of claim 8, wherein the signal processing portion is configured to: initiate the release period at an interval simultaneous with the predicted onset of the higher activity state in the subject. 11. The neural modulation system of claim 8, wherein the signal processing portion is configured to: initiate the release period at a delay interval after the predicted onset of the higher activity state in the subject. 12. The neural modulation system of claim 1, wherein the signal processing portion is configured to: predict the onset of the low activity state; andgenerate the blocking stimulus control signal for driving production of a an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject at least intermittently responsive to the predicted onset of a low activity state in the subject. 13. The neural modulation system of claim 12, wherein the signal processing portion is configured to generate the blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject at least intermittently prior to the predicted onset of a low activity state in the subject. 14. The neural modulation system of claim 12, wherein the signal processing portion is configured to generate the blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject at least intermittently simultaneously with the predicted onset of a low activity state in the subject. 15. The neural modulation system of claim 12, wherein the signal processing portion is configured to generate the blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject at least intermittently subsequent to the predicted onset of a low activity state in the subject. 16. The neural modulation system of claim 1, wherein the signal processing portion is configured to: determine the onset of the higher activity state in the subject; andinitiate a release period during which no blocking stimulus control signal is generated responsive to detecting the higher activity state in the subject. 17. The neural modulation system of claim 16, wherein the signal processing portion is configured to: initiate the release period substantially immediately upon detection of the onset of the higher activity state in the subject. 18. The neural modulation system of claim 16, wherein the signal processing portion is configured to: initiate the release period at a delay interval after detection of the onset of the higher activity state in the subject. 19. A neural modulation system comprising: a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;a signal processing portion configured to:distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; andgenerate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state; and a blocking stimulus source configured to be worn on the body of the subject and to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal. 20. The neural modulation system of claim 19, wherein the signal processing portion is configured to be located at a location remote from the body of the subject. 21. The neural modulation system of claim 19, wherein the signal processing portion is configured to be worn on the body of the subject. 22. The neural modulation system of claim 21, wherein the signal processing portion is packaged with the blocking stimulus source in a package configured to be worn on the body of the subject. 23. The neural modulation system of claim 19, wherein the blocking stimulus source is located in or on at least one of a wrap adapted to be positioned around at least a portion of the body of the subject, a bracelet configured to be worn on a limb of the subject, an anklet configured to be worn on a limb of the subject, a cuff configured to be worn on a limb of the subject, collar configured to be worn on a neck of the subject, or necklace configured to be worn on a neck of the subject. 24. A neural modulation system comprising: a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;a signal processing portion configured to:distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; andgenerate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first low activity state; anda blocking stimulus source configured to be positioned beneath at least a portion of the body of the subject and to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal. 25. The neural modulation system of claim 24, wherein the blocking stimulus source is configured to be located in or on at least one of a chair, a bed, a pad or a cushion. 26. A neural modulation system comprising: a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;a signal processing portion configured to:distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; andgenerate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state; anda blocking stimulus source configured to be implanted within the body of the subject and to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal. 27. A neural modulation system comprising: a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;a signal processing portion configured to:distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure;generate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state; and generate a release stimulus control signal for controlling discontinuation of production of the electrical field blocking stimulus when the subject is in the higher activity state; and a blocking stimulus source configured to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal. 28. The neural modulation system of claim 27, including a sensor operatively connected to the signal input structure and configured to generate the signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure responsive to an activity of the at least a portion of the body of the subject. 29. The neural modulation system of claim 27, wherein the signal processing portion is configured to repetitively generate the blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state and the release stimulus control signal for controlling discontinuation of production of the blocking stimulus when the subject is in the higher activity state. 30. The neural modulation system of claim 27, wherein the signal processing portion is configured to repetitively generate the blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state and the release stimulus control signal for controlling discontinuation of production of the electrical field blocking stimulus when the subject is in the higher activity state over a period of time sufficient to produce modulation of an immune response in a region innervated by the peripheral neural structure. 31. The neural modulation system of claim 27, wherein the signal processing portion is configured to generate the blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state and the release stimulus control signal for controlling discontinuation of production of the electrical field blocking stimulus when the subject is in the higher activity state cyclically, wherein each cycle includes a blocking period during which an electrical field blocking stimulus sufficient to produce reversible conduction block in a peripheral neural structure of a subject is produced while the subject is in a low activity state and a release period during which no electrical field blocking stimulus is delivered. 32. The neural modulation system of claim 31, wherein the signal processing portion is configured to generate the blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state and the release stimulus control signal for controlling discontinuation of production of the electrical field blocking stimulus when the subject is in the higher activity state cyclically at a rate of one cycle per day. 33. The neural modulation system of claim 27, wherein the signal processing portion is configured to generate the electrical field blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state and generate the release stimulus control signal for controlling discontinuation of production of the electrical field blocking stimulus when the subject is in the higher activity state in alternation according to a pre-set schedule. 34. A neural modulation system comprising: a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;a signal processing portion configured to: distinguish a first activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure;generate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first activity state; andgenerate a reversing stimulus control signal for driving production of a reversing stimulus to counter the electrical field blocking stimulus used to produce the reversible conduction block in the peripheral neural structure of the subject;a blocking stimulus source configured to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal; anda reversing stimulus source configured to produce a reversing stimulus responsive to the reversing stimulus control signal. 35. The neural modulation system of claim 34, wherein the reversing stimulus source includes at least a portion of the blocking stimulus source. 36. The neural modulation system of claim 34, wherein the reversing stimulus source includes at least one of a heating element, a cooling element, an electric field source, a magnetic field source, an electromagnetic transducer, an optical photon source, an acoustic energy source, or a chemical agent source. 37. A neural modulation system comprising: a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;a signal processing portion configured to: distinguish a first activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure;generate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first activity state;determine that producing the reversible conduction block in the peripheral neural structure of the subject while the subject is in a first activity state results in a desired effect in the subject; andgenerate a non-reversible blocking source control signal for driving a non-reversible blocking source to perform an action adapted for producing a non-reversible conduction block in the peripheral neural structure of the subject;a blocking stimulus source configured to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal; anda non-reversible blocking source configured to perform an action adapted for producing a non-reversible conduction block in the peripheral neural structure of the subject responsive to the non-reversible blocking source control signal. 38. The neural modulation system of claim 37, wherein the non-reversible blocking source includes at least one of a heat source, a cooling source, an electrical current source, an acoustic energy source, a photon source, a chemical agent source, or a surgical transection mechanism.
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