Compositions comprising edible oils and vitamins and/or minerals and methods for making the compositions
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/48
A61K-031/20
A61K-031/59
A61K-031/355
A61K-031/714
A61K-031/44
A61K-031/4985
A61P-043/00
출원번호
US-0579527
(2005-05-18)
등록번호
US-8173160
(2012-05-08)
국제출원번호
PCT/US2005/017413
(2005-05-18)
§371/§102 date
20061103
(20061103)
국제공개번호
WO2005/112654
(2005-12-01)
발명자
/ 주소
Schramm, Jack H.
McGrath, Jr., James W.
출원인 / 주소
PBM Pharmaceuticals, Inc.
대리인 / 주소
Locke Lord LLP
인용정보
피인용 횟수 :
3인용 특허 :
50
초록▼
The invention provides compositions for an administration to a mammal orally or in a suppository that include one or more edible oils (preferably including one or more omega-3 fatty acids), one or more plant stanols, phytosterols, or esters thereof, and admixed in the one or more edible oils one or
The invention provides compositions for an administration to a mammal orally or in a suppository that include one or more edible oils (preferably including one or more omega-3 fatty acids), one or more plant stanols, phytosterols, or esters thereof, and admixed in the one or more edible oils one or more water-soluble vitamins and/or minerals, for example, vitamins B6, B9 and/or B12. The invention also provides a method of making the compositions comprising mixing the foregoing components to form a suspension or emulsion of the vitamins and/or minerals in the edible oils. The mixture can be inserted into hollow soft or hard capsules, gelcaps or caplets. The edible oils can coat particles of the water-soluble vitamins and/or minerals, which may provide them with an improved absorption in the body due to an increased resistance to degradation in the acidic environment of the stomach.
대표청구항▼
1. A composition in an oral dosage form for an oral administration to a mammal, or in a form of a suppository, consisting essentially of: (a) one or more vitamins or minerals, or a combination thereof, in a combined amount that is effective for providing or enhancing one or more nutritional, medical
1. A composition in an oral dosage form for an oral administration to a mammal, or in a form of a suppository, consisting essentially of: (a) one or more vitamins or minerals, or a combination thereof, in a combined amount that is effective for providing or enhancing one or more nutritional, medical or other health benefits, or a combination thereof, to a mammal, wherein the one or more vitamins are vitamin B6, vitamin B9 or vitamin B12, or combination thereof, are water-soluble and oil-insoluble, are initially in a solid-state form, are exogenous to one or more edible oils that may be included in the composition and are in a form that is capable of being mixed with one or more edible oils;(b) one or more edible oils, or a combination thereof, in a combined amount that is effective for permitting the one or more vitamins or minerals, or combination thereof, to be mixed with the one or more edible oils, or combination thereof, said one or more edible oils substantially omega-3 fatty acids, omega-6, or omega-9 fatty acids, or a combination thereof, containing docosahexaenoic acid (DHA) in an amount greater than about 50 weight percent of the total weight of the edible oils, wherein said DHA is present in a triglyceride form and the one or more edible oils, or combination thereof, includes one or more substances that can provide a nutritional, medical or other health benefit, or a combination thereof, to a mammal;(c) one or more edible suspending agents, or a combination thereof, in a combined amount that is effective for initiating, enhancing or maintaining a suspension of the one or more vitamins or minerals, or combination thereof, in the one or more edible oils, or combination thereof, or for providing a nutritional, medical or other health benefit, or a combination thereof, to a mammal, or both, wherein the one or more edible suspending agents, or a combination thereof, selected from the group consisting of phytosterols, phytosterol esters, plant stanols or plant stanol esters, or a combination thereof;(d) one or more edible hollow oral dosage forms or hollow suppository forms;wherein the one or more vitamins or minerals, or combination thereof, are admixed with the one or more edible oils, or combination thereof, or the one or more suspending agents, or combination thereof, or both; andwherein the one or more vitamins or minerals, or combination thereof, the one or more edible oils, or combination thereof, and the one or more edible suspending agents, or combination thereof, are present in the composition in a form of a suspension, wherein the one or more vitamins or minerals, or combination thereof, are at least temporarily suspended in the one or more edible oils, or combination thereof;wherein the suspension or dispersion is inserted into the one or more edible hollow oral dosage forms or hollow suppository forms, or is formed into a solid suppository, to provide one or more unit dosage forms of the composition; and wherein a substantially uniform quantity of the one or more vitamins or minerals, or combination thereof, and the one or more edible oils, or combination thereof, is present in the one or more unit dosage forms, and wherein said composition is in a unit dosage form. 2. A composition of claim 1 wherein the one or more edible suspending agents include a combination of at least two or more of phytosterols, phytosterol esters, plant stanols and plant stanol esters. 3. A composition of claim 1 wherein the one or more edible suspending agents are beta-sitosterol, campesterol, stigmasterol, brassicasterol, or sitostanol, or a combination thereof. 4. A composition of claim 1 wherein the one or more edible suspending agents additionally include Sunflower oil, yellow or other beeswax or lecithin, or a combination thereof. 5. A composition of claim 1 wherein the one or more edible oils include one or more marine oils. 6. A composition of claim 1 wherein the one or more fatty acids are essential fatty acids. 7. A composition of claim 1 wherein the one or more fatty acids are omega-3 fatty acids. 8. A composition of claim 1 wherein the one or more fatty acids are DHA, eicosapentaenoic acid (EPA), alpha-linolenic acid (ALA), Arachidonic acid (ARA or AA) or gamma-linolenic acid (GLA), or a combination thereof. 9. A composition of claim 8 wherein the one or more omega-3 fatty acids are DHA, EPA or ALA, or a combination thereof. 10. A composition of claim 1 wherein the composition is an oral dosage form, and wherein the one or more vitamins or minerals, or combination thereof, have an ability to travel through an acidic environment of a stomach and into an intestinal tract of the mammal without being substantially degraded, and to be absorbed by the body of the mammal. 11. A composition of claim 1 wherein the one or more vitamins or minerals, or combination thereof, and the one or more edible oils, or combination thereof, are at least initially in the composition in a form of a suspension. 12. A composition of claim 11 wherein the suspension is substantially homogeneous, and is capable of remaining in a form of a substantially homogenous suspension at least for a period of time that is required to partially, substantially or fully fill one or more edible hollow oral dosage forms or hollow suppository forms with the suspension during a process for producing soft-gel, hard-gel or other capsules, other oral dosage forms or suppositories. 13. A composition of claim 1 wherein the one or more vitamins or minerals, or combination thereof, and the one or more edible oils, or combination thereof, are present in the composition in a form of a dispersion. 14. A composition of claim 1 wherein the composition additionally comprises one or more vitamins or minerals that are oil-soluble, or a combination thereof. 15. A composition of claim 14 wherein the one or more oil-soluble vitamins or minerals, or combination thereof, include vitamin D, vitamin E or vitamin K, or a combination thereof. 16. A composition of claim 15 wherein the one or more oil-soluble vitamins or minerals, or combination thereof, are exogenous to the one or more edible oils, and wherein the one or more oil-soluble vitamins or minerals, or combination thereof, are substantially dissolved in the one or more edible oils or are otherwise mixed therewith. 17. A composition of claim 1 wherein one or more edible antioxidant agents, or a combination thereof, are included in the composition, and wherein the one or more edible antioxidant agents, or combination thereof, are admixed with the one or more vitamins or minerals, or combination thereof, and the one or more edible oils, or combination thereof. 18. A composition of claim 1 wherein the vitamins or minerals, or combination thereof, are coated with one or more edible oils, or a combination thereof. 19. A composition of claim 1 wherein the composition includes Vitamin B9, and wherein the vitamin B9 is in the form of L-5-methyltetrahydrofolate, (6S)-tetrahydrofolic acid, 5 methyl-(6S)-tetrahydrofolic acid, 5 formyl-(6S)-tetrahydrofolic acid, 10 formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, (6S)-5-methyltetrahydrofolic acid or a polyglutamyl derivative of tetrahydrofolate. 20. A composition of claim 1 wherein the composition includes vitamin B12, and wherein the vitamin B12 is in the form of cyanocobalamin, cobalamin or cobalamin bound to recombinant intrinsic factor. 21. A composition of claim 1 wherein the composition includes vitamin B12 and wherein the vitamin B12 is triturated with anhydrous ascorbic acid. 22. A composition of claim 1 wherein the one or more edible suspending agents include a combination of two or more of phytosterols, phytosterol esters, plant stanols and plant stanol esters. 23. A composition of claim 1 wherein the composition includes a substantially uniform mixture of two or more of vitamin B6, vitamin B9 or vitamin B12, in any combination, and wherein components or particles that are present in the substantially uniform mixture are coated with, and at least initially suspended within, one or more omega-3 oils, or a combination thereof. 24. A composition of claim 23 wherein the substantially uniform mixture of two or more of vitamin B6, vitamin B9 or vitamin B12, in any combination, is a finely divided substantially uniformly mixed powder. 25. A composition of claim 1 wherein the composition is in an oral dosage form, and wherein the oral dosage form is a soft-gel or hard-gel capsule. 26. A composition of claim 1 wherein the composition is in a form of a suppository. 27. A composition of claim 1 wherein the composition has a shelf life of about two years under room temperature conditions. 28. A composition of claim 1 wherein the one or more unit dosage forms include: (a) a combined amount of about 700 mg of the one or more edible oils, including about 500 mg of omega-3 oil, about 350 mg of which is DHA and about 35 mg of which is EPA; (b) about 12.5 mg of vitamin B6, about 500 μg of vitamin B12 and about 1000 μg of vitamin B9; 283.9 mg of a combination of beta-sitosterol, campesterol, stigmasterol, brassicasterol, and sitostanol; and (d) a trace amount of tocopherol. 29. A composition of claim 1 wherein the one or more edible oils, or combination thereof, are present in the composition in a combined amount ranging from about 0.01 to about 90 weight percent and the one or more suspending agents, or combination thereof, are present in the composition in an amount ranging from about 1 to about 60 weight percent. 30. A composition of claim 1 wherein the composition includes vitamin B6 in an amount ranging from about 1 mg to about 50 mg, vitamin B9 in an amount ranging from about 100 μg to about 1000 μg, and vitamin B12 in an amount ranging from about 200 μg to about 2000 μg. 31. A composition for an oral administration to a mammal consisting essentially of: (a) one or more solid-state particles of one or more water-soluble vitamins or minerals, or a combination thereof, wherein the one or more vitamins are vitamin B6, vitamin B9 or vitamin B12, or a combination thereof, in a combined amount that is effective for providing or enhancing a nutritional, medical or other health benefit to the mammal;(b) one or more edible oils, or a combination thereof, wherein the one or more edible oils substantially omega-3 fatty acids, omega-6 fatty acids or omega-9 fatty acids, or a combination thereof, and are in a combined amount that is effective for permitting the solid-state particles to be at least temporarily suspended therein, said one or more edible oils containing DHA in an amount greater than about 50 weight percent of the total weight of the edible oils and said DHA is present in a triglyceride form; and(c) one or more edible suspending agents, or a combination thereof, in a combined amount that is effective for initiating, enhancing or maintaining a suspension of the one or more vitamins or minerals, or combination thereof, in the one or more edible oils, or for providing a nutritional, medical or other health benefit, or a combination thereof, to a mammal, or both, wherein the one or more edible suspending agents, or a combination thereof, selected from the group consisting of phytosterols, phytosterol esters, plant stanols or plant stanol esters, or a combination thereof; wherein the solid-state particles are admixed with the one or more edible oils, or combination thereof, or are at least temporarily suspended therein; and wherein said composition is in a unit dosage form. 32. A composition of claim 31 wherein the composition is included in a suppository. 33. A composition of claim 31 wherein the oral unit dosage form is a gelatin capsule. 34. A composition of claim 31 further comprising one or more antioxidant agents, or combination thereof, in an amount that is effective for preventing or reducing an oxidation, degradation or decomposition of the one or more water-soluble vitamins or minerals, or combination thereof, or the one or more edible oils, or combination thereof, wherein the one or more antioxidant agents, or combination thereof, are admixed with the one or more water-soluble vitamins or minerals, or combination thereof, and the one or more edible oils, or combination thereof. 35. A composition of claim 31 wherein the composition is in an oral unit dosage form, and wherein the water-soluble vitamins or minerals, or combination thereof, are coated with the one or more edible oils, or combination thereof, and have an enhanced ability to travel through a stomach to an intestinal tract of the mammal without being substantially degraded. 36. A composition of claim 31 further comprising one or more oil-soluble vitamins or minerals, or a combination thereof. 37. A composition for an oral administration, or an administration in a suppository, to a mammal consisting essentially of: (a) one or more solid-state particles of one or more water-soluble vitamins wherein the one or more water-soluble vitamins are vitamin B6, vitamin B9 or vitamin B12, or a combination thereof, and wherein the one or more water-soluble vitamins, or combination thereof, are in a combined amount that is effective for providing or enhancing a nutritional, medical or other health benefit to the mammal;(b) one or more edible oils, or a combination thereof, wherein the one or more edible oils substantially omega-3 fatty acids, omega-6 fatty acids or omega-9 fatty acids, in a combined amount that is effective for providing or enhancing a nutritional, medical or other health benefit to the mammal, said one or more edible oils containing DHA in an amount greater than about 50 weight percent of the total weight of the edible oils and said DHA is present in a triglyceride form; and(c) one or more edible suspending agents, or a combination thereof, in a combined amount that is effective for initiating, enhancing or maintaining a suspension of the one or more solid-state particles of the one or more water-soluble vitamins, or combination thereof, in the one or more edible oils, or combination thereof, or for providing a nutritional, medical or other health benefit, or a combination thereof, to a mammal, or both, wherein the one or more edible suspending agents, or a combination thereof, selected from the group consisting of phytosterols, phytosterol esters, plant stanols or plant stanol esters, or a combination thereof;wherein the solid-state particles are mixed with the one or more edible oils, or combination thereof, or are at least temporarily suspended therein; and wherein said composition is in a unit dosage form. 38. A composition of claim 37 wherein the composition is included within an oral unit dosage form. 39. A composition of claim 37 wherein the composition is included in a suppository. 40. A composition of claim 37 wherein the oral unit dosage form is a gelatin capsule. 41. A composition of claim 37 wherein the one or more omega-3 fatty acids is DHA, EPA or ALA, or a combination thereof. 42. A composition of claim 37 wherein the composition includes Vitamin B9, and wherein the vitamin B9 is in the form of L-5-methyltetrahydrofolate, (6S)-tetrahydrofolic acid, 5 methyl-(6S)-tetrahydrofolic acid, 5 formyl-(6S)-tetrahydrofolic acid, 10 formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, (6S)-5-methyltetrahydrofolic acid or a polyglutamyl derivative of tetrahydrofolate. 43. A composition of claim 37 wherein the composition includes vitamin B12, and wherein the vitamin B12 is in the form of cyanocobalamin, cobalamin or cobalamin bound to recombinant intrinsic factor. 44. A composition of claim 37 wherein the composition includes vitamin B12 and wherein the vitamin B12 is triturated with anhydrous ascorbic acid. 45. A composition of claim 37 wherein the one or more solid-state particles of the one or more water-soluble vitamins or minerals, or combination thereof, are coated with the one or more edible oils, or a combination thereof. 46. A composition of claim 37 wherein the composition includes a combination or two or more suspending agents. 47. A composition of claim 46 wherein the suspending agents additionally include Sunflower oil, yellow or other beeswax or lecithin, or a combination thereof. 48. A composition of claim 46 wherein the two or more suspending agents include a combination of two or more of phytosterols, phytosterol esters, plant stanols or plant stanol esters. 49. A composition of claim 37 wherein the composition is in an oral dosage form, and wherein the water-soluble vitamins or minerals, or combination thereof, have an enhanced ability to travel through a stomach to an intestinal tract of the mammal without being substantially degraded. 50. A composition of claim 37 further comprising one or more oil-soluble vitamins or minerals, or a combination thereof. 51. A composition of claim 37 wherein the composition includes vitamin B6 in an amount ranging from about 1 mg to about 50 mg, vitamin B9 in an amount ranging from about 100 μg to about 1000 μg, and vitamin B12 in an amount ranging from about 200 μg to about 2000 μg. 52. A method for producing a composition in an oral dosage form for an oral administration to a mammal, or in a form of a suppository, consisting essentially of: (a) providing one or more vitamins or minerals, or a combination thereof, in a combined amount that is effective for providing or enhancing one or more nutritional, medical or other health benefits, or a combination thereof, to a mammal, wherein the one or more vitamins or minerals are vitamin B6, vitamin B9 or vitamin B12, or combination thereof, are water-soluble and oil-insoluble, are initially in a solid-state form, are exogenous to one or more edible oils that may be included in the composition and are in a form that is capable of being mixed with one or more edible oils;(b) providing one or more edible oils, or a combination thereof, in a combined amount that is effective for permitting at least some of the one or more vitamins or minerals, or combination thereof, to be mixed therewith, or at least temporarily suspended therein, or for forming a continuous or disperse phase of a dispersion, wherein the one or more edible oils, or combination thereof, said one or more edible oils substantially omega-3 fatty acids, omega-6, or omega-9 fatty acids, or a combination thereof, containing DHA in an amount greater than about 50 weight percent of the total weight of the edible oils, wherein said DHA is present in a triglyceride form includes one or more substances that can provide a nutritional, medical or other health benefit, or a combination thereof, to a mammal;(c) providing one or more edible suspending agents, or a combination thereof, in a combined amount that is effective for initiating, enhancing or maintaining a suspension of the one or more vitamins or minerals, or combination thereof, in the one or more edible oils, or combination thereof, or for providing a nutritional, medical or other health benefit, or a combination thereof, to a mammal, or both, wherein the one or more edible suspending agents, or a combination thereof, selected from the group consisting of phytosterols, phytosterol esters, plant stanols or plant stanol esters, or a combination thereof;(d) providing one or more edible hollow oral dosage forms or hollow suppository forms;(e) optionally, mixing the one or more vitamins or minerals, or combination thereof, for a period of time and under conditions that are effective for producing a substantially uniform mixture of the one or more vitamins or minerals, or combination thereof;(f) optionally, mixing the one or more vitamins or minerals, or combination thereof, with an amount of an aqueous liquid, and for a period of time and under conditions, that are effective for forming an aqueous solution;(g) optionally, mixing the one or more edible oils, or combination thereof, for a period of time and under conditions that are effective for producing a uniform mixture of the one or more edible oils, or combination thereof,(h) optionally, mixing the one or more edible suspending agents, or combination thereof, for a period of time and under conditions that are effective for producing a uniform mixture of the one or more edible suspending agents;(i) combining the one or more vitamins or minerals, or combination thereof, with the one or more edible oils, or combination thereof, or the one or more edible suspending agents, or combination thereof, or both, for a period of time and under conditions that are effective for: (i) producing a suspension of at least some of the one or more vitamins or minerals, or particles or combination thereof, in the one or more edible oils, or combination thereof, wherein the one or more vitamins or minerals, or particles or combination thereof, and the one or more edible oils, or combination thereof, remain in suspension for at least a period of time that is sufficient to enable the one or more edible hollow dosage forms or hollow suppository forms to be partially or fully filled with the suspension; or(ii) producing a dispersion; and(j) inserting the suspension or dispersion into the one or more edible hollow oral dosage forms or hollow suppository forms, or forming a solid suppository therewith, in an amount that is effective for partially or fully filling the one or more edible hollow oral dosage forms or hollow suppository forms so as to form one or more unit dosage forms, wherein substantially the same quantity of each of the components that are present in the composition becomes present in each of the one or more unit dosage forms. 53. A method of claim 52 wherein the one or more edible suspending agents include a combination of two or more of phytosterols, phytosterol esters, plant stanols or plant stanol esters. 54. A method of claim 52 wherein the one or more edible suspending agents are beta-sitosterol, campesterol, stigmasterol, brassicasterol, or sitostanol, or a combination thereof. 55. A method of claim 52 wherein the one or more edible suspending agents additionally include Sunflower oil, yellow or other beeswax or lecithin, or a combination thereof. 56. A method of claim 52 wherein the one or more edible oils includes one or more marine oils. 57. A method of claim 52 wherein the one or more fatty acids are essential fatty acids. 58. A method of claim 52 wherein the one or more fatty acids are omega-3 fatty acids. 59. A method of claim 52 wherein the one or more fatty acids are DHA, EPA, ALA, ARA, AA or GLA, or a combination thereof. 60. A method of claim 58 wherein the one or more omega-3 fatty acids are DHA, EPA or ALA, or a combination thereof. 61. A method of claim 52 wherein the composition is in an oral dosage form, and wherein the one or more vitamins or minerals, or combination thereof, have an enhanced ability to travel through an acidic environment of a stomach and into an intestinal tract of the mammal without being substantially degraded, and to be absorbed by the body of the mammal. 62. A method of claim 52 wherein the one or more vitamins or minerals, or combination thereof, and the one or more edible oils, or combination thereof, are combined in a manner that at least initially produces a suspension. 63. A method of claim 62 wherein the suspension is substantially homogeneous, and is capable of remaining in a form of a substantially homogenous suspension at least for a period of time that is required to partially, substantially or fully fill one or more edible hollow oral dosage forms or hollow suppository forms with the suspension during a process for producing soft-gel, hard-gel or other capsules, other oral dosage forms or suppositories. 64. A method of claim 52 wherein the one or more vitamins or minerals, or combination thereof, and the one or more edible oils, or combination thereof, are combined in a manner that produces a dispersion. 65. A method of claim 52 wherein the method additionally comprises the step of providing one or more vitamins or minerals that are oil-soluble, or a combination thereof. 66. A method of claim 65 wherein the one or more oil-soluble vitamins or minerals, or combination thereof, include vitamin D, vitamin E or vitamin K, or a combination thereof. 67. A method of claim 65 wherein the one or more oil-soluble vitamins or minerals, or combination thereof, are exogenous to the one or more edible oils, and wherein the one or more oil-soluble vitamins or minerals, or combination thereof, are substantially dissolved in the one or more edible oils or are otherwise mixed therewith. 68. A method of claim 52 wherein one or more edible antioxidant agents, or a combination thereof, are provided, and wherein the one or more edible antioxidant agents, or combination thereof, are admixed with the one or more vitamins or minerals, or combination thereof, and the one or more edible oils, or combination thereof. 69. A method of claim 52 wherein the vitamins or minerals, or combination thereof, are coated with one or more edible oils, or a combination thereof. 70. A method of claim 52 wherein the composition includes Vitamin B9, and wherein the vitamin B9 is in the form of L-5-methyltetrahydrofolate, (6S)-tetrahydrofolic acid, 5 methyl-(6S)-tetrahydrofolic acid, 5 formyl-(6S)-tetrahydrofolic acid, 10 formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, (6S)-5-methyltetrahydrofolic acid or a polyglutamyl derivative of tetrahydrofolate. 71. A method of claim 52 wherein the composition includes vitamin B12, and wherein the vitamin B12 is in the form of cyanocobalamin, cobalamin or cobalamin bound to recombinant intrinsic factor. 72. A method of claim 52 wherein the composition includes vitamin B12 and wherein the vitamin B12 is triturated with anhydrous ascorbic acid. 73. A method of claim 52 wherein the one or more edible suspending agents include a combination of two or more of phytosterols, phytosterol esters, plant stanols and plant stanol esters. 74. A method of claim 52 wherein the composition includes a substantially uniform mixture of two or more of vitamin B6, vitamin B9 or vitamin B12, in any combination, and wherein components or particles that are present in the substantially uniform mixture are coated with, and at least initially suspended within, one or more omega-3 oils, or a combination thereof. 75. A method of claim 74 wherein the substantially uniform mixture of two or more of vitamin B6, vitamin B9 or vitamin B12, in any combination, is a finely divided substantially uniformly mixed powder. 76. A method of claim 52 wherein the composition is in an oral dosage form, and wherein the oral dosage form is a soft-gel or hard-gel capsule. 77. A method of claim 52 wherein the composition is in a form of a suppository. 78. A method of claim 52 wherein the composition has a shelf life of about two years under room temperature conditions. 79. A method of claim 52 wherein the one or more unit dosage forms include: (a) a combined amount of about 700 mg of the one or more edible oils, including about 500 mg of omega-3 oil, about 350 mg of which is DHA and about 35 mg of which is EPA;(b) about 12.5 mg of vitamin B6, about 500 μg of vitamin B12 and about 1000 μg of vitamin B9;(c) about 105.3 mg of a combination of beta-sitosterol, campesterol, stigmasterol, brassicasterol, and sitostanol; and(d) a trace amount of tocopherol. 80. A method of claim 52 wherein the components that are included in the composition, with the exception of the one or more edible hollow oral dosage forms or hollow suppository forms, are mixed, shaken or circulated together at least one time prior to inserting the components into the one or more edible hollow oral dosage forms or hollow suppository forms in a manner that permits substantially a uniform quantity of the components to be included in each of the one or more edible hollow oral dosage forms or hollow suppository forms. 81. A method of claim 52 wherein the one or more edible oils, or combination thereof, are present in the composition in a combined amount ranging from about 0.01 to about 90 weight percent and the one or more suspending agents, or combination thereof, are present in the composition in an amount ranging from about 1 to about 60 weight percent. 82. A composition of claim 52 wherein the composition includes vitamin B6 in an amount ranging from about 1 mg to about 50 mg, vitamin B9 in an amount ranging from about 100 μg to about 1000 μg, and vitamin B12 in an amount ranging from about 200 μg to about 2000 μg. 83. A method for preparing a composition for an oral administration to a mammal, or in a suppository, consisting essentially of: (a) providing one or more solid state particles of one or more water-soluble vitamins or minerals, or a combination thereof, wherein the one or more vitamins are vitamin B6, vitamin B9 or vitamin B12, or a combination thereof, in a combined amount that is effective for providing or enhancing a nutritional, medical or other health benefit to the mammal;(b) providing one or more edible oils, or a combination thereof, including one or more fatty acids in a combined amount that is effective for permitting the one or more water-soluble vitamins or minerals, or combination thereof, to be at least temporarily suspended therein said one or more edible oils substantially omega-3 fatty acids, omega-6, or omega-9 fatty acids, or a combination thereof, containing DHA in an amount greater than about 50 weight percent of the total weight of the edible oils, wherein said DHA is present in a triglyceride form and the one or more edible oils, or combination thereof;(c) providing one or more edible suspending agents, or a combination thereof, in a combined amount that is effective for initiating, enhancing or maintaining a suspension of the one or more solid state particles of the one or more water-soluble vitamins or minerals, or combination thereof, in the one or more edible oils, or combination thereof, or for providing a nutritional, medical or other health benefit, or a combination thereof, to a mammal, or both, wherein the one or more edible suspending agents, or a combination thereof, selected from the group consisting of phytosterols, phytosterol esters, plant stanols or plant stanol esters, or a combination thereof;(d) optionally, mixing the one or more water-soluble vitamins or minerals, or combination thereof, for a period of time and under conditions that are sufficient to produce a substantially uniform mixture of the one or more water-soluble vitamins or minerals, or combination thereof;(e) optionally, mixing the one or more edible oils, or combination thereof, for a period of time and under conditions that are sufficient to produce a substantially uniform mixture of the one or more edible oils, or combination thereof;(f) suspending, at least temporarily, an amount of the one or more water-soluble vitamins or minerals, or combination thereof, within an amount of the one or more edible oils, or combination thereof, that is effective for producing a suspension of the solid-state particles of the one or more water-soluble vitamins or minerals, or combination thereof, within the one or more edible oils, or mixtures thereof; and(g) injecting or inserting a resulting suspension into one or more oral dosage forms or hollow suppository forms, wherein the oral dosage forms are hard or soft capsules, gelatin capsules, caplets or gelatin caplets. 84. A method of claim 83 wherein vitamin B9 is provided and wherein the vitamin B9 is in the form of L-5-methyltetrahydrofolate, (6S)-tetrahydrofolic acid, 5 methyl-(6S)-tetrahydrofolic acid, 5 formyl-(6S)-tetrahydrofolic acid, 10 formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, (6S)-5-methyltetrahydrofolic acid or polyglutamyl derivatives of tetrahydrofolate. 85. A method of claim 83 wherein vitamin B12 is provided and wherein the vitamin B12 is in the form of cyanocobalamin, cobalamin or cobalamin bound to recombinant intrinsic factor. 86. A method of claim 83 wherein vitamin B12 is provided and wherein the vitamin B12 is triturated with anhydrous ascorbic acid. 87. A method of claim 83 wherein the one or more edible suspending agents, or combination thereof, is blended with the one or more edible oils, or combination thereof. 88. A method of claim 83 wherein the composition includes one or more omega-3 fatty acids and wherein the one or more omega-3 fatty acids are DHA, EPA or ALA, or combination thereof. 89. A method of claim 88 wherein the one or more edible suspending agents include a combination of two or more of phytosterols, phytosterol esters, plant stanols and plant stanol esters. 90. A method of claim 83 wherein the composition includes vitamin B6 in an amount ranging from about 1 mg to about 50 mg, vitamin B9 in an amount ranging from about 100 μg to about 1000 μg, and vitamin B12 in an amount ranging from about 200 μg to about 2000 μg. 91. A method for preparing a composition in an oral form for an oral administration to a mammal, or in a form of a suppository, consisting essentially of: (a) providing one or more solid-state particles of one or more water soluble vitamins or minerals, or a combination thereof, wherein the one or more vitamins are vitamin B6, vitamin B9 or vitamin B12, or a combination thereof, in a combined amount that is effective for providing or enhancing a nutritional, medical or other health benefit to the mammal;(b) mixing the solid-state particles in an amount of water that is sufficient to form an aqueous solution;(c) providing one or more edible emulsifiers, or a combination thereof;(d) providing one or more edible oils, or combination thereof, including one or more fatty acids, said one or more edible oils substantially omega-3 fatty acids, omega-6, or omega-9 fatty acids, or a combination thereof, containing DHA in an amount greater than about 50 weight percent of the total weight of the edible oils, wherein said DHA is present in a triglyceride form and the one or more edible oils, or combination thereof;(e) providing one or more edible suspending agents, or a combination thereof, in a combined amount that is effective for initiating, enhancing or maintaining a suspension of the one or more solid state particles of the one or more water-soluble vitamins or minerals, or combination thereof, in the one or more edible oils, or combination thereof, or for providing a nutritional, medical or other health benefit, or a combination thereof, to a mammal, or both, wherein the one or more edible suspending agents, or a combination thereof, selected from the group consisting of phytosterols, phytosterol esters, plant stanols or plant stanol esters, or a combination thereof;(f) optionally, mixing the one or more edible oils, or combination thereof, for a period of time and under conditions that are sufficient to produce a uniform mixture of the one or more edible oils, or combination thereof;(g) mixing the aqueous solution with the one or more edible emulsifiers, or combination thereof, and the one or more edible oils, or combination thereof, under conditions that are sufficient to form an emulsion; and(h) injecting or otherwise inserting the emulsion into one or more hollow oral dosage forms or hollow suppository forms, wherein the hollow oral dosage forms are soft or hard capsules, gelatin capsules, caplets or gelatin caplets. 92. A method for enhancing the quantity of one or more vitamins or minerals, or combination thereof, that are absorbed by an intestinal tract of a mammal and delivered to the mammal's body after the mammal consumes one or more vitamins or minerals, or combination thereof, comprising orally administering to the mammal a composition of claim 1 in an oral dosage form and in an amount that is effective for enhancing the quantity of one or more vitamins or minerals, or combination thereof, that are absorbed by the intestinal tract of the mammal and delivered to the mammal's body after the mammal consumes the composition. 93. A method for enhancing the nutrition, health or medical condition of a mammal comprising administering to the mammal orally, or in a suppository, a composition of claim 1 in an amount that is effective for enhancing the nutrition, health or medical condition of the mammal. 94. A method for enhancing the nutrition, health or medical condition of a mammal comprising: (a) providing an effective amount of a composition according to claim 1; and(b) administering the effective amount of a composition according to claim 1 to the mammal orally, or in a form of a suppository. 95. A method for enhancing the nutrition, health or medical condition of a mammal comprising: (a) providing an effective amount of a composition according to claim 37; and(b) administering the effective amount of the composition according to claim 37 to a mammal orally, or in a form of a suppository. 96. A composition in an oral dosage form for an oral administration to a mammal consisting essentially of: (a) one or more water-soluble vitamins or minerals, or a combination thereof, wherein the one or more vitamins are vitamin B6, vitamin B9 or vitamin B12, or a combination thereof, in a combined amount that is effective for providing or enhancing one or more nutritional, medical or other health benefits, or a combination thereof, to a mammal, wherein the one or more water-soluble vitamins or minerals, or combination thereof, are in a form that is capable of being mixed with one or more edible oils;(b) one or more edible oils, or a combination thereof, in a combined amount that is effective for permitting the one or more water-soluble vitamins or minerals, or combination thereof, to be mixed with the one or more edible oils, said one or more edible oils substantially omega-3 fatty acids, omega-6 fatty acids or omega-9 fatty acids, or a combination thereof, containing DHA in an amount greater than about 50 weight percent of the total weight of the edible oils and said DHA is present in a triglyceride form;(c) one or more edible suspending agents in a combined amount that is effective for initiating, enhancing or maintaining a suspension of the one or more water-soluble vitamins or minerals, or combination thereof, in the one or more edible oils, or for providing a nutritional, medical or other health benefit, or a combination thereof, to a mammal, or both, wherein the one or more suspending agents selected from the group consisting of phytosterols, phytosterol esters, plant stanols or plant stanol esters, or a combination thereof;(d) two or more edible hollow oral dosage forms;wherein the one or more water-soluble vitamins minerals, or combination thereof, and the one or more edible oils, or combination thereof, are present in the compositions in a manner or form that permits substantially a uniform quantity of the one or more water-soluble vitamins or minerals, or combination thereof, and the one or more edible oils, or combination thereof, to be inserted into each of the one or more hollow oral dosage forms, and wherein the one or more water-soluble vitamins or minerals, or combination thereof, has an ability to travel through an acidic environment of a stomach and into the intestinal tract of the mammal without being substantially or fully degraded, and to be absorbed by the body of the mammal. 97. The composition of claim 1 further comprising one or more edible antioxidant agents, or a combination thereof in a combined amount that is effective for preventing or reducing an oxidation, degradation or other decomposition of the one or more vitamins or minerals, or combination thereof, the one or more edible oils, or combination thereof, or one or more other components that are included in the composition, or any combination thereof. 98. The composition of claim 1 further comprising wherein the one or more edible diluents, or a combination thereof, in a combined amount that is effective for diluting, rendering less potent, thinning, weakening or facilitating a physical separation of one or more components that are included in the composition. 99. The composition of claim 1 further comprising one or more edible emulsifiers, or a combination thereof, in a combined amount that is effective for causing or enhancing a formation of an emulsion. 100. The composition of claim 1 further comprising one or more edible surfactants, or a combination thereof, in a combined amount that is effective for reducing a surface tension when dissolved or otherwise included in an aqueous liquid or reducing an interfacial tension between two liquids, or between a liquid and a solid. 101. The method of claim 52, between steps (d) and (e), further comprising: providing one or more edible antioxidant agents, or a combination thereof in a combined amount that is effective for preventing or reducing an oxidation, degradation or other decomposition of the one or more vitamins or minerals, or combination thereof, the one or more edible oils, or combination thereof, or one or more other components that are included in the composition, or any combination thereof. 102. The method of claim 52, between steps (d) and (e), further comprising: providing one or more edible diluents, or a combination thereof, in a combined amount that is effective for diluting, rendering less potent, thinning, weakening or facilitating a physical separation of one or more components that are included in the composition. 103. The method of claim 52, between steps (d) and (e), further comprising: providing one or more edible emulsifiers, or a combination thereof, in a combined amount that is effective for causing or enhancing a formation of an emulsion. 104. The method of claim 52, between steps (d) and (e), further comprising: providing one or more edible surfactants, or a combination thereof, in a combined amount that is effective for reducing a surface tension when dissolved or otherwise included in an aqueous liquid or reducing an interfacial tension between two liquids, or between a liquid and a solid. 105. The method of claim 52, after step (h), further comprising: combining the antioxidant agents, diluents, emulsifiers, surfactants or other optional ingredients, or combination thereof, with the one or more vitamins or minerals or the one or more edible oils, or with any combination thereof. 106. The composition of claim 96, wherein the one or more edible antioxidant agents, or a combination thereof in a combined amount that is effective for preventing or reducing an oxidation, degradation or other decomposition of the one or more vitamins or minerals, or combination thereof, the one or more edible oils, or combination thereof, or one or more other components that are included in the composition, or any combination thereof. 107. The composition of claim 96, wherein the one or more edible diluents, or a combination thereof, in a combined amount that is effective for diluting, rendering less potent, thinning, weakening or facilitating a physical separation of one or more components that are included in the composition. 108. The composition of claim 96, wherein the one or more edible emulsifiers, or a combination thereof, in a combined amount that is effective for causing or enhancing a formation of an emulsion.
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