Prouroguanylin, and synthetic analogs or proteolytic cleavage products derived from it, as therapeutic and diagnostic agents for diseases involving salt and/or fluid homeostasis
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/00
A61P-009/00
A61P-009/12
A61P-007/10
출원번호
US-0596493
(2005-05-16)
등록번호
US-8173596
(2012-05-08)
국제출원번호
PCT/US2005/016937
(2005-05-16)
§371/§102 date
20070717
(20070717)
국제공개번호
WO2006/001931
(2006-01-05)
발명자
/ 주소
Goy, Michael F.
Moss, Nicholas G.
Qian, Xun
출원인 / 주소
The University of North Carolina at Chapel Hill
대리인 / 주소
Jenkins, Wilson, Taylor & Hunt, P.A.
인용정보
피인용 횟수 :
0인용 특허 :
5
초록▼
A method for treating a disorder characterized by salt retention, fluid retention, and combinations thereof. A method for determining the presence of or the progression of a disorder characterized by salt retention, fluid retention, salt loss, fluid loss, and combinations thereof. An immunoassay kit
A method for treating a disorder characterized by salt retention, fluid retention, and combinations thereof. A method for determining the presence of or the progression of a disorder characterized by salt retention, fluid retention, salt loss, fluid loss, and combinations thereof. An immunoassay kit for detecting a level of prouroguanylin in a sample.
대표청구항▼
1. A method for treating a disorder characterized by salt retention, fluid retention, and combinations thereof, in a patient in need thereof, the method comprising administering an effective amount of preprouroguanylin, prouroguanylin, or analog thereof, to the patient, thereby producing diuresis, n
1. A method for treating a disorder characterized by salt retention, fluid retention, and combinations thereof, in a patient in need thereof, the method comprising administering an effective amount of preprouroguanylin, prouroguanylin, or analog thereof, to the patient, thereby producing diuresis, natriuresis, or a combination thereof, wherein said analog comprises preprouroguanylin or prouroguanylin modified by the addition of a non-peptide moiety selected from the group consisting of a radiolabelling component, a fluorescent moiety, a fatty acid group, a carbohydrate, and a polymer. 2. The method of claim 1, wherein the disorder is selected from the group consisting of kidney disease, heart disease, liver disease, hypertension, and combinations thereof. 3. The method of claim 1, wherein the preprouroguanylin, prouroguanylin, or analog thereof, is administered by infusion. 4. The method of claim 1, wherein the preprouroguanylin, prouroguanylin, or analog thereof, is selected from the group consisting of a synthetic, natural, and recombinant preprouroguanylin, prouroguanylin, or analog thereof. 5. The method of claim 1, wherein the effective amount of preprouroguanylin, prouroguanylin, or analog thereof, is administered in combination with at least one other drug that has diuretic properties, natriuretic properties, or both diuretic and natriuretic properties. 6. The method of claim 5, wherein the other drug is a diuretic. 7. The method of claim 6, wherein the diuretic is selected from the group consisting of carbonic anhydrase inhibitors, thiazide-like diuretics, loop or high ceiling diuretics, and potassium-sparing diuretics. 8. The method of claim 6, wherein the diuretic is selected from the group consisting of furosemide, bumetadine, torsemide, hydrochlorothiazide, triamterine, indapamide, ethocrinic acid, spironolactone, and metolazone.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (5)
Marnett Lawrence J. (Nashville TN) Honn Kenneth V. (Detroit MI) Johnson Carl R. (Detroit MI) Chen Yung-fa (Tainan MI TWX) Shimoji Katsu-ichi (Detroit MI), Cyclic hydroxamic acids.
Seipp Ulrich (Aachen DEX) Vollenberg Werner (Stolberg DEX) Englberger Werner (Stolberg DEX) Geist Cornelia (Aachen DEX) Haurand Michael (Stolberg DEX), Oxyalkyne compounds, pharmaceutical compositions containing them and processes for preparing such compounds and composit.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.