초록 ▼

Apparatus and methods for delivering a clotted biological component (such as blood, autologous conditioned plasma (ACP), platelet-rich plasma (PRP), bone marrow aspirate (BMA), demineralized bone matrix, anticoagulants and/or clotting agents, or combination of these materials) into a tissue void (fo

Apparatus and methods for delivering a clotted biological component (such as blood, autologous conditioned plasma (ACP), platelet-rich plasma (PRP), bone marrow aspirate (BMA), demineralized bone matrix, anticoagulants and/or clotting agents, or combination of these materials) into a tissue void (for example, a bone void such as a bone tunnel, socket, opening or cavity), and then cutting the clotted biological component with a cutting or shearing mechanism at the tissue surface. The apparatus is provided with a tube and a cutting or shearing mechanism (provided on or within the distal end of the tube) that is actuated to cut or break off the clot at the desired insertion length. The tube may then be placed over the next tissue void so that the obturator drives the next clot into the next tissue void until all tissue voids are filled. Upon insertion at the defect site, the biological component advances the healing of the damaged tissue and tissue growth.

대표청구항 ▼

1. A device for filling a tissue void in a patient, comprising: a tube having an inner lumen configured to house a clotted biological component;the clotted biological component housed within the inner lumen;an obturator sized and configured to pass through the inner lumen of the tube and to advance

1. A device for filling a tissue void in a patient, comprising: a tube having an inner lumen configured to house a clotted biological component;the clotted biological component housed within the inner lumen;an obturator sized and configured to pass through the inner lumen of the tube and to advance the clotted biological component through the tube to a distal end of the tube; anda cutting mechanism provided at the distal end of the tube to cut the clotted biological component, wherein the cutting mechanism is a blade having an outer surface about perpendicular to a longitudinal axis of the tube. 2. The device of claim 1, wherein the clotted biological component is a blood clot. 3. The device of claim 1, wherein the clotted biological component comprises a material selected from the group consisting of blood, autologous conditioned plasma, platelet-rich plasma, bone marrow aspirate, demineralized bone matrix, anticoagulants, clotting agents and growth factors. 4. The device of claim 1, wherein the tissue void is a bone void. 5. The device of claim 4, wherein the bone void is a tunnel, socket, opening or cavity. 6. The device of claim 1, wherein the device is configured to sequentially fill at least two tissue voids with material from the same clotted biological component. 7. The device of claim 1, wherein the cutting mechanism is a circular blade capable of being rotated relative to a longitudinal axis of the tube from a first, closed position to a second, open position, wherein in the second, open position the clotted biological component advances through the tube. 8. The device of claim 1, wherein the cutting mechanism is integral to the tube. 9. The device of claim 1, further comprising a matrix disposed within at least a part of the tube to allow formation of the clotted biological component on or within the matrix and subsequent transport and placement of the clotted biological component in the tissue void. 10. The device of claim 9, wherein the matrix is a flexible strand, a porous material, or a tape. 11. The device of claim 9, wherein the matrix is a suture strand securely attached to the tube. 12. The device of claim 1, wherein the clotted biological component further comprises collagen or allograft. 13. A method of providing a desired amount of a clotted biological component into an anatomical void formed in anatomical tissue, comprising the steps of providing a tube in the vicinity of the anatomical void, the tube having an inner lumen, a proximal end and a distal end, and a cutting mechanism at the distal end;forming a clotted biological component within the tube;advancing the clotted biological component towards the distal end of the tube so that at least a part of the clotted biological component exits the tube; andcutting off the at least part of the clotted biological component that exits the tube and filling the anatomical void by actuating a blade of the cutting mechanism from an open position to a closed position, wherein, when the blade is in the open position, the clotted biological component can pass through a most distal end of the tube and, when the blade is in the close position, an inner lumen of the tube is fully blocked so that the clotted biological component cannot pass through the most distal end of the tube. 14. The method of claim 13, wherein the at least part of the clotted biological component fully fills the anatomical void. 15. The method of claim 13, wherein the at least part of the clotted biological component partially fills the anatomical void. 16. The method of claim 13, wherein the anatomical void is a bone tunnel or socket. 17. The method of claim 13, further comprising the steps of: sealing the distal end of the tube with a distal cap;injecting at least one of blood and autologous conditioned plasma within the tube through the proximal end of the tube;optionally, providing a filler material within the tube and mixing the least one of blood and autologous conditioned plasma with the filler material to form the clotted biological component;removing the distal cap of the tube;placing the distal end of the tube over the anatomical void;advancing an obturator though the inner lumen of the tube and into the anatomical void, so that at least a part of the clotted biological component is advanced within the anatomical void;actuating a cutting or shearing mechanism located at the distal end of the tube, to cut the clotted biological component at a surface of the anatomical tissue and allow the at least part of the clotted biological component to fill in the anatomical void. 18. The method of claim 17, wherein the filler material is a stabilizing or a therapeutic material.