Method of using pomegranate extracts for increasing prostate specific antigen doubling time
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-036/00
출원번호
US-0282800
(2007-03-15)
등록번호
US-8178137
(2012-05-15)
국제출원번호
PCT/US2007/064112
(2007-03-15)
§371/§102 date
20090130
(20090130)
국제공개번호
WO2007/106909
(2007-09-20)
발명자
/ 주소
Liker, Harley
출원인 / 주소
Pom Wonderful, LLC
대리인 / 주소
Cotman IP Law Group, PLC
인용정보
피인용 횟수 :
3인용 특허 :
22
초록▼
Pomegranate juice consumption by a patient may be used to treat prostate cancer. Prior to the present invention, it has been observed that various pomegranate compositions have cancer chemopreventive properties on various in vitro treatment of human prostate cancer cell lines and in vivo treatment o
Pomegranate juice consumption by a patient may be used to treat prostate cancer. Prior to the present invention, it has been observed that various pomegranate compositions have cancer chemopreventive properties on various in vitro treatment of human prostate cancer cell lines and in vivo treatment of human prostate cancer cell lines xenografted in athymic nude mice. Until the discovery of the present invention, it was not known if there is an efficacy for treating prostate cancer in human patient by any route of administration. The present invention provides a method of treating a subject with prostate cancer a composition comprising a therapeutically effective amount of an extract from pomegranate fruit. The extract of pomegranate may be a juice extract of pomegranate, an extract from inner or outer peel of pomegranate, or mixture thereof. Pomegranate juice may be used to treat subjects with rising serum PSA after prostate surgery or radiotherapy.
대표청구항▼
1. A method of increasing a prostate specific antigen (PSA) doubling time in treating a person with prostate cancer comprising: selecting a subject with rising serum PSA; andadministering to said a subject a composition comprising a therapeutically effective amount of a pomegranate extract comprisin
1. A method of increasing a prostate specific antigen (PSA) doubling time in treating a person with prostate cancer comprising: selecting a subject with rising serum PSA; andadministering to said a subject a composition comprising a therapeutically effective amount of a pomegranate extract comprising a higher content of high molecular weight polyphenols compared to pomegranate juice from arils, wherein said therapeutically effective amount increases a prostate specific antigen doubling time, wherein said pomegranate extract is formed from an insoluble byproduct component obtained bycrushing and squeezing whole pomegranates including inner and outer peels and seeds of said whole pomegranates to yield a juice component and an insoluble byproduct component, andseparating said juice component from said insoluble byproduct component. 2. The method of claim 1 further comprising: measuring a prostate specific antigen doubling time in said subject to confirm a slowing of said prostate specific antigen doubling time. 3. The method of claim 1, wherein said composition comprises at least one dosage unit of said pomegranate extract administered daily over an extended period to decrease serum PSA levels. 4. The method of claim 2, wherein said at least one dosage unit comprises at least 30 to 3000 umol of polyphenols. 5. The method of claim 1, wherein said subject has a rising serum PSA of greater than about 0.2 ng/ml and less about than 5 ng/ml. 6. The method of claim 1, wherein said subject has a confirmed prostate biopsy showing a Gleason score of 7 or less. 7. The method of claim 3, wherein at least one periodic measurement is performed every 3 months. 8. The method of claim 3, wherein said PSA level of said subject from said at least one periodic measurement is evaluated for decreased PSA level to determine an efficacy of treatment. 9. The method of claim 3, wherein said PSA level of said subject from said at least one periodic measurement is evaluated for lengthened PSA doubling time to determine an efficacy of treatment. 10. The method of claim 3, wherein said extended period is at least three months. 11. The method of claim 3, wherein said extended period is at least one year. 12. The method of claim 3, wherein said extended period is at least two years. 13. The method of claim 3, wherein said at least one dosage unit further comprises a pharmaceutically acceptable carrier. 14. The method of claim 3, wherein said at least one dosage unit is in a form selected from tablets, suspensions, implants, solutions, emulsions, capsules, powders, syrups, liquid compositions, ointments, lotions, creams, pastes, and gels. 15. The method of claim 1, wherein said composition is in a form selected from nutritional supplements, pharmaceutical preparations, vitamin supplements, food additives, or foods supplements. 16. The method of claim 1, wherein said extract is a solid extract. 17. The method of claim 1, wherein said extract is a liquid extract. 18. The method of claim 1, wherein said subject is a subject with rising serum PSA after prostate surgery. 19. The method of claim 1, wherein said subject is a subject with rising serum PSA after radiotherapy.
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