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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0154410 (2008-05-22) |
등록번호 | US-8185202 (2012-05-22) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 18 인용 특허 : 402 |
Methods and devices for reducing phrenic nerve stimulation of cardiac pacing systems involve delivering a pacing pulse to a ventricle of a heart. A transthoracic impedance signal is sensed, and a deviation in the signal resulting from the pacing pulse may be used to determine phrenic nerve stimulati
Methods and devices for reducing phrenic nerve stimulation of cardiac pacing systems involve delivering a pacing pulse to a ventricle of a heart. A transthoracic impedance signal is sensed, and a deviation in the signal resulting from the pacing pulse may be used to determine phrenic nerve stimulation. Methods may further involve detecting the phrenic nerve stimulation from the pacing pulse by delivering two or more pacing pulse to the ventricle of the heart, and determining a temporal relationship. A pacing vector may be selected from the two or more vectors that effects cardiac capture and reduces the phrenic nerve stimulation. A pacing voltage and/or pulse width may be selected that provides cardiac capture and reduces the phrenic nerve stimulation. In other embodiments, a pacing pulse width and a pacing voltage may be selected from a patient's strength-duration curve that effects cardiac capture and reduces the phrenic nerve stimulation.
1. A medical device, comprising: a plurality of electrodes electrically coupled to a heart;a pulse generator coupled to the plurality of electrodes and configured to sense cardiac activity and deliver pacing pulses to a heart using at least some of the plurality of electrodes;a transthoracic impedan
1. A medical device, comprising: a plurality of electrodes electrically coupled to a heart;a pulse generator coupled to the plurality of electrodes and configured to sense cardiac activity and deliver pacing pulses to a heart using at least some of the plurality of electrodes;a transthoracic impedance sensor configured to sense a transthoracic impedance signal; anda control circuit coupled to the pulse generator and the transthoracic impedance sensor, the control circuit configured to detect a breathing event based on a temporal association between pacing pulse delivery during a non-refractory period of the heart and a perturbation in the transthoracic impedance signal, the control circuit further configured to verify that the detected breathing event is representative of phrenic nerve stimulation resulting from pacing pulse delivery based on detection of an additional perturbation in the transthoracic impedance signal that is temporally associated with an additional pacing pulse delivered during a cardiac refractory period of the heart. 2. The device of claim 1, wherein the control circuit is configured to detect the breathing event and verify that the breathing event is representative of phrenic nerve stimulation based on detection of one or both of inspiration and expiration corresponding to pacing pulse delivery timing. 3. The device of claim 1, wherein the control circuit is configured to detect the breathing event and verify that the breathing event is representative of phrenic nerve stimulation based on detection of a change in one or both of inspiration and expiration superimposed over a normal breathing pattern, where the change corresponds with pacing pulse delivery timing. 4. The device of claim 1, wherein the control circuit is configured to open a time window following delivery of each pacing pulse, and evaluate the transthoracic impedance signal during the time window for the perturbation indicative of phrenic nerve stimulation. 5. The device of claim 4, wherein the control circuit is configured to open the time window following delivery of a left-ventricular pacing pulse and close the time window after expiration of a predetermined period following left-ventricular pacing pulse delivery. 6. The device of claim 1, wherein the control circuit is configured to alter one or more of a pacing vector, pacing pulse amplitude, and pacing pulse width to reduce the phrenic nerve stimulation. 7. The device of claim 1, wherein the control circuit is configured to search for one or more of new pacing vectors, pacing parameter settings, and pulse generator control parameters that effect capture with reduced phrenic nerve stimulation. 8. The device of claim 1, wherein the control circuit is configured, in response to determining that the device is in an ambulatory mode, to change a pacing vector or one or more pacing parameters, wait for the next scheduled pacing pulse to be delivered, and determine if capture occurs using the changed pacing vector or the one or more changed pacing parameters. 9. The device of claim 1, wherein the control circuit is configured, in response to determining that the device is in an ambulatory mode, to adjust one or more pacing parameters from a strength-duration curve established for a patient that effects cardiac capture and reduces phrenic nerve stimulation. 10. The device of claim 1, wherein the control circuit comprises a band-pass filter centered at a pacing rate and coupled to an output of the transthoracic impedance sensor, the filter configured to detect the perturbation in the transthoracic impedance signal indicative of phrenic nerve stimulation. 11. The device of claim 1, wherein the control circuit comprises a lock-in amplifier configured to analyze the pacing pulses and the transthoracic impedance signal for indications of phrenic nerve stimulation. 12. The device of claim 1, wherein the control circuit is configured to verify that the detected breathing event is representative of phrenic nerve stimulation resulting from pacing pulse delivery independent of cardiac motion. 13. The device of claim 1, wherein a signal processor is provided in a patient-external device or system, the signal processor and the control circuit coupled to respective communication devices to facilitate wireless communication between the signal processor and the control circuit. 14. The device of claim 1, wherein a signal processor is provided in a network server system, the signal processor and the control circuit coupled to respective communication devices to facilitate wireless communication between the signal processor and the control circuit. 15. A medical device, comprising: a plurality of electrodes electrically coupled to a heart;a pulse generator coupled to the plurality of electrodes and configured to sense cardiac activity and deliver pacing pulses to a heart using at least some of the plurality of electrodes;a transthoracic impedance sensor configured to sense a transthoracic impedance signal; anda control circuit coupled to the pulse generator and the transthoracic impedance sensor, the control circuit configured to detect a breathing event based on a temporal association between pacing pulse delivery during a non-refractory period of the heart and a perturbation in the transthoracic impedance signal, the control circuit further configured to verify that the detected breathing event is representative of phrenic nerve stimulation resulting from pacing pulse delivery based on detection of an additional perturbation in the transthoracic impedance signal that is temporally associated with an additional delivered pacing pulse. 16. The device of claim 15, wherein the control circuit is configured to detect the breathing event and verify that the breathing event is representative of phrenic nerve stimulation based on detection of one or both of inspiration and expiration corresponding to pacing pulse delivery timing. 17. The device of claim 15, wherein the control circuit is configured to detect the breathing event and verify that the breathing event is representative of phrenic nerve stimulation based on detection of a change in one or both of inspiration and expiration superimposed over a normal breathing pattern, where the change corresponds with pacing pulse delivery timing. 18. The device of claim 15, wherein the control circuit is configured to open a time window following delivery of each pacing pulse, and evaluate the transthoracic impedance signal during the time window for the perturbation indicative of phrenic nerve stimulation. 19. The device of claim 18, wherein the control circuit is configured to open the time window following delivery of a left-ventricular pacing pulse and close the time window after expiration of a predetermined period following left-ventricular pacing pulse delivery. 20. The device of claim 15, wherein the control circuit is configured to alter one or more of a pacing vector, pacing pulse amplitude, and pacing pulse width to reduce the phrenic nerve stimulation. 21. The device of claim 15, wherein the control circuit is configured to search for one or more of new pacing vectors, pacing parameter settings, and pulse generator control parameters that effect capture with reduced phrenic nerve stimulation. 22. The device of claim 15, wherein the control circuit is configured, in response to determining that the device is in an ambulatory mode, to change a pacing vector or one or more pacing parameters, wait for the next scheduled pacing pulse to be delivered, and determine if capture occurs using the changed pacing vector or the one or more changed pacing parameters. 23. The device of claim 15, wherein the control circuit is configured, in response to determining that the device is in an ambulatory mode, to adjust one or more pacing parameters from a strength-duration curve established for a patient that effects cardiac capture and reduces phrenic nerve stimulation. 24. The device of claim 15, wherein the control circuit comprises a band-pass filter centered at a pacing rate and coupled to an output of the transthoracic impedance sensor, the filter configured to detect the perturbation in the transthoracic impedance signal indicative of phrenic nerve stimulation. 25. The device of claim 15, wherein the control circuit comprises a lock-in amplifier configured to analyze the pacing pulses and the transthoracic impedance signal for indications of phrenic nerve stimulation. 26. The device of claim 15, wherein the control circuit is configured to verify that the detected breathing event is representative of phrenic nerve stimulation resulting from pacing pulse delivery independent of cardiac motion. 27. The device of claim 15, wherein a signal processor is provided in a patient-external device or system, the signal processor and the control circuit coupled to respective communication devices to facilitate wireless communication between the signal processor and the control circuit. 28. The device of claim 15, wherein a signal processor is provided in a network server system, the signal processor and the control circuit coupled to respective communication devices to facilitate wireless communication between the signal processor and the control circuit.
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