IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0154136
(2002-05-22)
|
등록번호 |
US-8187326
(2012-05-29)
|
발명자
/ 주소 |
- Hammer, Joseph J.
- Contiliano, Joseph H.
- Vyakarnam, Murty N.
- Brown, Kelly R.
|
출원인 / 주소 |
- Advanced Technologies and Regenerative Medicine, LLC.
|
대리인 / 주소 |
Roberts Mlotkowski Safran & Cole, P.C.
|
인용정보 |
피인용 횟수 :
6 인용 특허 :
62 |
초록
▼
The present invention relates to tissue scaffold implant devices useful in the repair and/or regeneration of diseased and/or damaged musculoskeletal tissue and that include a tissue scaffold component fixedly attached to a scaffold fixation component via a polymeric adhesive layer, and to methods of
The present invention relates to tissue scaffold implant devices useful in the repair and/or regeneration of diseased and/or damaged musculoskeletal tissue and that include a tissue scaffold component fixedly attached to a scaffold fixation component via a polymeric adhesive layer, and to methods of making such tissue scaffold implant devices.
대표청구항
▼
1. A tissue scaffold implant device, comprising: a non-woven textile tissue scaffold component having a top surface and a bottom surface, the tissue scaffold component comprising a soluble polymer,a tissue scaffold support, having a top surface and a fixation post integral therewith and extending op
1. A tissue scaffold implant device, comprising: a non-woven textile tissue scaffold component having a top surface and a bottom surface, the tissue scaffold component comprising a soluble polymer,a tissue scaffold support, having a top surface and a fixation post integral therewith and extending opposite from said top surface, the tissue scaffold support comprising a soluble thermoplastic polymer, andan adhesive layer between said scaffold component and said top surface of said tissue scaffold support, said adhesive layer comprising a soluble polymer having a top surface and a bottom surface, the bottom surface of the scaffold component is fixedly attached to the top surface of the adhesive layer and the bottom surface of the adhesive layer is fixedly attached to the top surface of the scaffold support,andsaid soluble polymer of the tissue scaffold component is selected from the group consisting of polyalkylene oxalates, polyamides, polycarbonates, polyorthoesters, polyoxaesters, polyamidoesters, polyanhydrides and polyphosphazenes, and aliphatic polyesters selected from the group consisting of glycolide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate (1,3-dioxan-2-one), δ-valerolactone, β-butyrolactone, ε-decalactone, 2,5-diketomorpholine, pivalolactone, α,α-diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one and 6,8-dioxabicycloctane-7-one. 2. The device of claim 1 wherein said adhesive layer soluble polymer is thermoplastic. 3. The device of claim 1, wherein the top surface of said tissue scaffold support is non-porous. 4. The device of claim 1, wherein the scaffold support comprises a biocompatible ceramic. 5. The device of claim 1, wherein the tissue scaffold component and the scaffold support comprise different bioabsorbable polymers. 6. The device of claim 5, wherein the tissue scaffold component is a wet-laid nonwoven textile comprising 90 mole % PGA/10 mole % PLA copolymer fibers and the scaffold support comprises 85 mole % PLA/15 mole % PGA copolymer.
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