Methods and apparatus for isolating platelets from blood
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B04B-001/06
B01L-003/14
B01D-021/26
출원번호
US-0951701
(2010-11-22)
등록번호
US-8187477
(2012-05-29)
발명자
/ 주소
Dorian, Randel
King, Scott R.
Storrs, Richard W.
출원인 / 주소
Hanuman, LLC
대리인 / 주소
Harness, Dickey
인용정보
피인용 횟수 :
8인용 특허 :
334
초록▼
A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the den
A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
대표청구항▼
1. A method for separating platelets from blood for application to a patient in a medical treatment, comprising: placing the blood in a container above a moveable surface that at least partially defines a volume by a sidewall extending from a top to a bottom;sedimenting platelets from the blood plac
1. A method for separating platelets from blood for application to a patient in a medical treatment, comprising: placing the blood in a container above a moveable surface that at least partially defines a volume by a sidewall extending from a top to a bottom;sedimenting platelets from the blood placed in the container near the moveable surface within the container;accessing the volume through at least one of two access ports passing into the container through a cap at the top of the container; andwithdrawing at least a portion of the sedimented platelets while venting the container through a vent formed in the cap. 2. The method of claim 1, wherein sedimenting platelets further includes: centrifuging the container containing the blood and a float component having the moveable surface;wherein the float component moves in the container during centrifugation and defines the moveable surface in the container. 3. The method of claim 2, wherein the moveable surface is defined within the container; and wherein the centrifuging forms a thin layer of erythrocytes on the moveable surface in the container within the volume. 4. The method of claim 3, wherein centrifuging the container moves the float component to a position between a first fraction and a second fraction of the whole blood; wherein after cessation of the centrifuging, the float component is maintained in the position between the first fraction and the second fraction. 5. The method of claim 4, further comprising: maintaining a third fraction within a receptor cavity of the float component. 6. The method of claim 4, further comprising: placing the float component near the bottom of the container prior to the centrifuging the container;wherein the centrifuging causes the float component to move from near the bottom of the container towards the top of the container through the placed blood. 7. The method of claim 6, wherein withdrawing at least the portion of the sedimented platelets includes withdrawing at least the portion of the sedimented platelets from near a depression near a center of the moveable surface of the float component;wherein the depression forms a low region in the float component. 8. The method of claim 7, wherein withdrawing the sediment platelets includes directly accessing the sedimented platelets at a center of the float component through the container when accessing the volume. 9. The method of claim 8, wherein accessing the volume includes accessing the volume to withdraw the sedimented platelets through a second port of the at least two ports separate from a first port for introducing the blood. 10. A method for separating platelets from blood for application to a patient in a medical treatment, comprising: placing the blood in a container at least partially defining a volume by a sidewall extending from a top to a bottom;positioning a float in the container near the bottom, wherein the float is operable to move towards the top of the container;centrifuging the container, the float, and the blood placed in the container to: cause the float to move upward within the container during the centrifuging from the near the bottom of the container such that a layer of erythrocytes forms on a collection surface of the float, andsediment platelets from the blood placed in the container on the layer of erythrocytes; andaccessing the volume through at least one of two separate access ports passing into the container at the top of the container while venting the container through a vent separate passing through the top of the container, wherein the two access ports and at least an opening for the vent are all defined separately by a cap that engages the sidewall at the top of the container. 11. The method of claim 10, wherein placing the blood in the container includes placing the blood between the top of the container and the collection surface. 12. The method of claim 11, wherein the collection surface is defined by an upper surface of the float to contain the layer of erythrocytes and the sedimented platelets. 13. The method of claim 11, further comprising: connecting a syringe to the at least one access port to withdraw the sedimented platelets. 14. The method of claim 13, further comprising: withdrawing the sedimented platelets into the syringe though a tube placed in the container. 15. The method of claim 14, further comprising: maintaining the tube in the container during the centrifuging. 16. The method of claim 15, wherein the tube extends from at least one of the two access ports and withdrawing the sedimented platelets includes withdrawing the sedimented platelets through the tube and through the at least one of the two access ports. 17. The method of claim 16, wherein connecting a syringe includes connecting the syringe to the at least one of the two access ports. 18. A method for separating platelets from blood for application to a patient in a medical treatment, comprising: placing the blood in a container at least partially defining a volume by a sidewall extending from a top to a bottom;positioning a float component in the container near the bottom, wherein the float component is operable to move towards the top of the container and the float has sidewalls that are substantially parallel to the sidewalls of the container when the float is near the bottom of the container;centrifuging the container, the float component, and the blood placed in the container to: cause the float component to move within the container during the centrifuging from near the bottom of the container such that a layer of erythrocytes form on a collection surface of the float component, andsediment platelets from the blood placed in the container on the layer of erythrocytes and near a low region defined near a center of the float component;ceasing centrifugation to allow the float component to be held at a selected position within the container via cooperation of the sidewall and the sidewall of the float component;accessing the volume through at least one of two access ports passing into the container through a cap integrated at the top of the container, wherein the two ports are separately defined through the cap; andwithdrawing directly at least a portion of the sedimented platelets in the container from near the low region while venting the container through a vent defined through the cap separate from the two ports in the cap of the container and the sidewalls of the float remain substantially parallel to sidewalls of the container. 19. The method of claim 18, wherein accessing the volume further comprises: connecting a syringe to the at least one port of the two ports; andactuating the syringe to perform the withdrawing of the sedimented platelets. 20. The method of claim 19, further comprising: maintaining a tube extending from the at least one port of the two ports;wherein withdrawing of the sedimented platelets includes withdrawing the sedimented platelets through the tube extending from the at least one port of the two ports and into the syringe. 21. The method of claim 19, wherein connecting a syringe to the at least one port of the two ports includes connecting the syringe to the at least one port offset from a center of the container.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (334)
Zine ; Jr. Anthony R. (Corning NY), Access device for centrifugal separation assemblies.
Katz, Adam J.; Llull, Ramon; Futrell, William J.; Hedrick, Marc H.; Benhaim, Prosper; Lorenz, Hermann Peter; Zhu, Min, Adipose-derived stem cells and lattices.
Latham ; Jr. Allen (Jamaica Plain MA) Jorgensen Glen E. (Marlborough MA) Sibinga Theodoor H. S. (Boston MA) Plante Joseph R. (Millis MA) Knapp Tracey E. (Hanover MA), Apheresis apparatus and method.
Latham ; Jr. Allen (Jamaica Plain MA) Jorgensen Glen E. (Marlborough MA) Sibinga Theodoor H. S. (Boston MA) Plante Joseph R. (Millis MA) Knapp Tracey E. (Hanover MA), Apheresis apparatus for separating an intermediate density component from whole blood.
Higgins, Joel C.; Leach, Michael D.; Woodell-May, Jennifer E.; Miller, Brandon, Apparatus and method for separating and concentrating fluids containing multiple components.
Coelho Philip Henry ; Kingsley Phil ; Brausch Jim ; Godsey James H. ; Rock Gail,CAX, Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby.
Deniega Jose C. (Lake Forest CA) Duff Daniel H. (Irvine CA) Schoendorfer Donald W. (Santa Ana CA) Miller William R. (Santa Ana CA), Apparatus and methods for generating leukocyte free platelet concentrate.
Deniega Jose C. (Lake Forest CA) Duff Daniel H. (Irvine CA) Schoendorfer Donald W. (Santa Ana CA) Miller William R. (Santa Ana CA), Apparatus and methods for generating leukocyte free platelet concentrate.
McEwen James A. (10551 Bamberton Drive Richmond ; British Columbia CAX V7A 1K6) Godolphin William J. (827 West 24th Avenue Vancouver ; British Columbia CAX V5Z-2C2) Bohl Rainer M. (41 East 40th Avenu, Apparatus for collecting blood.
Hlavinka Dennis (Golden CO) Langley Robert (Westminster CO) Taylor Linda (Littleton CO) Walker John C. (Boulder CO), Apparatus for separating particles.
McEwen James A. (Richmond CAX) Godolphin William J. (Vancouver CAX) Bohl Rainer M. (Vancouver CAX) Dance Mark N. (Vancouver CAX) Furse Marty L. (Vancouver CAX) Osborne John C. (Port Coquitlam CAX), Apparatus for separating phases of blood.
Giesler Richard ; Chapman John R. ; Ellis Dale R. ; Bischof Daniel F., Apparatus for separation of biologic components from heterogeneous cell populations.
Hwang Yean Yow (Cypress CA) Ritchey Brian (Long Beach CA) Schoendorfer Donald W. (Santa Ana CA), Automated blood component separation procedure and apparatus promoting different functional characteristics in multiple.
Zelmanovic David ; Colella Gregory M. ; Hetherington Edward J. ; Chapman Evelyn Sabrinah ; Paseltiner Lynn, Automated method and device for identifying and quantifying platelets and for determining platelet activation state usi.
Blatt William F. (Framingham MA) Agranat Edward A. (Weston MA) Rigopulos Peter N. (Melrose MA), Blood fractionating process and apparatus for carrying out same.
Brown Richard I ; Foley John T ; Min Kyungyoon ; Sahlin Mark, Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent.
Zaleske David J. ; Peretti Giuseppe,ITX ; Caruso Enzo ; Rossetti Francesco,ITX ; Randolph Mark, Bonding of cartilage pieces using isolated chondrocytes and a biological gel.
Brown Richard I. (Northbrook IL) Smith Sidney (Lake Forest IL) Cerny David E. (Crystal Lake IL) Foley John T. (Wheeling IL), Centrifugation pheresis system.
Brown Richard I. (Northbrook IL) Smith Sidney (Lake Forest IL) Cerny David E. (Crystal Lake IL) Foley John T. (Wheeling IL), Centrifugation system having an interface detection surface.
Levine Robert A. (31 Pilgrim La. Guilford CT 06437) Wardlaw Stephen C. (191 North Cove Rd. Old Saybrook CT 06475), Centrifuged material layer measurements taken in an evacuated tube.
Schoendorfer Donald W. (67 Balboa Coves Santa Ana CA) McLaughlin William F. (67 Balboa Coves Newport Beach CA 92663), Closed hemapheresis system and method.
Cunningham Robert W. (Cohasset MA) Koch Durmus (Demarest NJ) Mura Janine R. (Colchester CT) Felix Augustus (Providence RI) Halick Gary V. (East Greenwich RI), Closed wound orthopaedic drainage and autotransfusion system.
Rich ; Jr. William E. (Mountain View CA) Smith Frank C. (Felton CA) McNeill Janet L. (Sunnyvale CA), Combination apparatus and method for chromatographic separation and quantitative analysis of multiple ionic species.
Bacehowski David V. (Wildwood IL) Cullis Herbert M. (Silver Spring MD) VanBaelen Armand R. (Rolling Meadows IL), Combination disposable plastic blood receiving container and blood component centrifuge.
Prior Jeffrey J. ; Wallace Donald G. ; Sierra David H. ; DeLustro Frank A., Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof.
Burnouf-Radosevich Miryana (Wavrin FRX) Burnouf Thierry (Wavrin FRX), Concentrate of thrombin coagulable proteins, the method of obtaining same and therapeutical use thereof.
Levine Robert A. (31 Pilgrim La. Guilford CT 06437) Wardlaw Stephen C. (191 N. Cove Rd. Old Saybrook CT 06475), Constitutent layer harvesting from a centrifuged sample in a tube.
Lake William C. (Laguna Niguel CA) Giesler Richard (Deerfield IL) Epps Dennis Van (Cary IL) Chapman John R. (Lake Villa IL) Martinson Jeffrey A. (Mundelein IL) Ellis Dale R. (Wonder Lake IL) Aono Fre, Continuous centrifugation process for the separation of biological components from heterogeneous cell populations.
Schoendorfer Donald W. (Santa Ana CA) Berthe Claude E. (San Dimas CA), Continuous centrifugation system and method for directly deriving intermediate density material from a suspension.
Lake William C. ; Giesler Richard ; Van Epps Dennis ; Chapman John R. ; Martinson Jeffrey A. ; Ellis Dale R. ; Aono Frederick ; Bischof Daniel F., Continuous process for the separation of biologic components from heterogeneous cell populations.
Fischel Richard J. (Minneapolis MN) Brumfield Robert C. (Anaheim CA), Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear.
Bormann Thomas J. (Melville NY) Matkovich Vlado I. (Glen Cove NY) Gsell Thomas C. (Glen Cove NY) Pall David B. (Roslyn Estates NY), Device and method for separating plasma from a biological fluid.
Pall David B. (Glen Cove NY) Gsell Thomas C. (Glen Cove NY) Muellers Brian T. (Rockville Centre NY), Device for processing blood for human transfusion.
Delmas Olivier (14 ; rue Bellevue 37250 Montbazon FRX), Device for producing a supernatant of activated thrombocytes, method for implementing the device and supernatant obtaine.
Benebo Biebele Opubo ; Benjamin Edmund Glenn ; Edwards Robert Douglas ; Konrad John Joseph ; Wells Timothy Leroy ; Zalesinski Jerzy Maria, Electrolytic method of depositing gold connectors on a printed circuit board.
Conston Stanley R. (San Carlos CA) Dapper Gregory S. (Newark CA) Murphy Aileen L. (Menlo Park CA) Raeder-Devens Jennifer (Oakland CA) Yamamoto Ronald (San Francisco CA), Embolization plugs for blood vessels.
Coleman Charles M. (958 Washington Rd. Pittsburgh PA 15228) Kendrick William (34 Willowbrook Dr. Doylestown PA 18901), Fluid collection, separation and dispensing tube.
Zelmanovic David ; Colella Gregory M. ; Hetherington Edward J. ; Chapman Evelyn Sabrinah ; Paseltiner Lynn, Highly sensitive, accurate, and precise automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples.
Wenthold Randal M. ; Hall ; II Robert T. ; Andrus Robert G. ; Brinda Paul D. ; Cosentino Louis C. ; Reggin Robert F. ; Pigott Daniel T., Hollow fiber membranes and method of manufacture.
O\Donnell ; Jr. Francis E. (6035 Lindell Blvd. St. Louis MO 63112) Nalbandian Robert M. (901 S. Skinker ; Apt. E. Clayton MO 63105) Mammen Eberhard (652 Woods La. Grosse Point Woods MI 48236), Intraocular lens implant and method of locating and adhering within the posterior chamber.
Prockop Darwin J. ; Pereira Ruth F. ; Leeper Dennis B. ; O'Hara Michael D., Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects.
Peterson Dale R. ; Nousek-Goebl Nancy, Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration.
Wolf Stephen J. (Hillsborough NJ) Mart Robert K. (Martinsville NJ) Otto Scott C. (Yardley PA), Locking holder for a pair of syringes and method of use.
hlin L. Erik (Stocksund SEX) Unger H. Peter (Stockholm SEX) Westberg J. Eric (Liding SEX), Method and apparatus for centrifugal batch separation of blood.
Biesel Wolfgang (Ottweiler DEX) Geibel Johannes (Wadern DEX) Brass Henning (Homburg DEX), Method and apparatus for the separation of blood into its components.
Figdor Carl G. (The Netherlands Cancer Inst. Plesmanlaan 121 1066 CX Amsterdam NLX) Bont Willy S. (The Netherlands Cancer Inst. Plesmanlaan 121 1066 CX Amsterdam NLX), Method and device for the separation and isolation of blood or bone marrow components.
Jonsson Svante U. R. (Glumslv SEX), Method and machine based on the principle of centrifugation for cytapheresis such as platelet apheresis, and for plasma.
Cullis Herbert M. (Silver Spring MD) Dorsey Evelyn E. (Washington DC) De Vries James H. (McHenry IL), Method and system for fractionating a quantity of blood into the components thereof.
Rothman Ulf S. E. (Bjrred SEX) Jacobsson Sten A. L. (Malm SEX), Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method.
Rothman, Ulf S. E.; Jacobsson, Sten A. L., Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method.
Caplan Arnold I. (1300 Oakridge Dr. Cleveland Heights OH 44121) Haynesworth Stephen E. (3643 Antisdale Rd. Cleveland Heights OH 44118), Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells.
Philip Henry Coelho ; Phil Kingsley ; Jim Brausch ; James H. Godsey ; Gail Rock CA; Trista K. Madsen ; Sona B. Frausto, Method for preparing thrombin for use in a biological glue.
Pall David B. (Glen Cove NY) Gsell Thomas C. (Glen Cove NY) Muellers Brian T. (Rockville Centre NY), Method for processing blood for human transfusion.
Dolecek, Victor D.; Baugh, Robert F.; Rivera, John G.; McKay, William F.; Marx, Jeffery C., Method for the production of a blood component composition.
Caplan Arnold I. (1300 Oakridge Dr. Cleveland Heights OH 44121) Haynesworth Stephen E. (3643 Antisdale Rd. Cleveland Heights OH 44118), Method for treating connective tissue disorders.
Hendriks Marc,NLX ; Verhoeven Michel,NLX ; Cahalan Linda L.,NLX ; Cahalan Patrick T.,NLX ; Fouache Benedicte,NLX, Method of modifying the surface of a medical device.
Patat Jean-Louis (Paris FRX) Delmas Olivier (Montbazon FRX) Schmitthaeusler Roland (Montigny-le-Bretonneux FRX), Method of preparing a biological adhesive enriched with platelet factors, and application.
Patat Jean-Louis,FRX ; Delmas Olivier,FRX ; Schmitthaeusler Roland,FRX, Method of preparing a biological glue able to coagulate simply by addition of calcium ions.
Neumann Hans-Jrgen (St. Wendel DEX) Meisberger Artur (St. Wendel DEX) Weber Wolfram (Spiesen DEX), Method of separating blood and apparatus for carrying out the method.
Williams Stuart K. (Wilmington DE) Jarrell Bruce E. (Philadelphia PA), Method of treating a synthetic naturally occurring surface with a collagen laminate to support microvascular endothelial.
Antanavich Richard D. (Paso Robles CA) Dorian Randel (Orinda CA), Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant.
Michalski Catherine (Lille FRX) Dernis Dominique (Marquette lez Lille FRX), Process for preparing a human thrombin concentrate intended for therapeutic use.
Bui-Khac Trung (Montreal CAX) Lavoie Lise (St-Eustache CAX) Michel St Picq Dominique (Ste-Genevive CAX), Process for the obtention of a biological adhesive made of concentrated coagulation factors by “salting-out”.
Schwinn Horst (Marburg DEX) Heimburger Norbert (Marburg DEX) Kumpe Gerhardt (Wetter DEX) Drescher Heinz H. (Neustadt DEX), Process for the purification of the blood clotting factors, II, VII, IX and/or X.
Levine Robert A. (Guilford CT) Wardlaw Stephen C. (Old Saybrook CT) Hart Allan H. (Guilford CT), Quantification of fibrinogen in whole blood samples contained in a tube using a float to separate materials.
Kaleskas Edward W. (Jefferson MA) Minior ; Jr. Thaddeus G. (Bedford MA) Nott Sepideh H. (Fall River MA), Rotary centrifuge bowl and seal for blood processing.
Chitte, Ratnakar Ravindra; Dey, Sabita, STREPTOMYCES MEGASPORUS SD5, PROCESS FOR THE ISOLATION THEREOF, NOVEL FIBRINOLYTIC ENZYME PREPARED THEREFROM, PROCESS FOR THE PRODUCTION OF SAID ENZYME AND METHOD OF TREATMENT OF THROMBOLYTIC DISORDE.
Coleman Charles M. (958 Washington Rd. Pittsburgh PA 15228) Kendrick William (34 Willowbrook Dr. Doylestown PA 18901), Separator float and tubular body for blood collection and separation and method of use thereof.
MacPhee Martin James ; Drohan William Nash ; Liau Gene ; Haudenschild Christian, Supplemented and unsupplemented tissue sealants, method of their production and use.
MacPhee Martin James ; Drohan William Nash ; Lasa ; Jr. Carlos I.,PHX ; Liau Gene ; Haudenschild Christian, Supplemented and unsupplemented tissue sealants, methods of their production and use.
MacPhee Martin James ; Drohan William Nash ; Woolverton Christoper J., Supplemented and unsupplemented tissue sealants, methods of their production and use.
Pall David B. (Roslyn Estates NY) Gsell Thomas C. (Glen Cove NY) Matkovich Vlado I. (Glen Cove NY) Bormann Thomas (Seaford NY), System and method for processing biological fluid.
Baugh, Robert F.; Lim, Lisa M.; Johnston, Julie S.; Rivera, John G.; Dolecek, Victor D., System and method for the production of autologous platelet gel.
Bennet Richard I. (Crewe GB2) Berthiaume Guy H. (Charlotte NC) Haw Michael F. (Charlotte NC) Melber ; Jr. Joseph G. (Charlotte NC) Neill Jimmie (Sherrilles Ford NC), Thickness sensor comprising a leaf spring means, and a light sensor.
Landrigan, Matthew D.; Leach, Michael D.; Higgins, Joel C., Apparatus and method for separating and concentrating fluids containing multiple components.
Leach, Michael D.; Higgins, Joel C.; Swift, Matthew; Gordon, Nathan, Apparatus and method for separating and concentrating fluids containing multiple components.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.