초록

The present invention provides porous barrier compositions comprising color change indicators and methods of making and using the same.

대표청구항 ▼

1. A self-sealing barrier composition comprising: a sintered porous matrix, the sintered porous matrix comprising at least one plastic, at least one absorbent material, and particles of at least one color change indicator, wherein the particles of the at least one color change indicator in the sinte

1. A self-sealing barrier composition comprising: a sintered porous matrix, the sintered porous matrix comprising at least one plastic, at least one absorbent material, and particles of at least one color change indicator, wherein the particles of the at least one color change indicator in the sintered porous matrix dissolve upon contact with liquid and at least partially change the color of the sintered porous matrix, and the sintered porous matrix is self-sealing upon contact with the liquid. 2. The self-sealing barrier composition of claim 1, wherein the at least one color change indicator comprises an organic dye, food grade dye, or mixtures thereof. 3. The self-sealing barrier composition of claim 2, wherein the color change indicator comprises FD&C Blue No. 1, FD&C Blue No. 2, FD&C Green No. 3, FD&C Red No. 40, FD&C Red No. 3, FD&C Yellow No. 5, FD&C Yellow No. 6, Solvent Red 24, Solvent Red 26, Solvent Red 164, Solvent Yellow 124, Solvent Blue 35, or mixtures thereof. 4. The self-sealing barrier composition of claim 1, wherein the color change indicator is responsive to pH. 5. The self-sealing barrier composition of claim 4, wherein the color change indicator comprises methyl violet, eosin yellow, malachite green, thymol blue, methyl yellow, bromophenol blue, congo red, methyl orange, bromocresol green, methyl red, litmus, bromocresol purple, bromophenol red, bromothymol blue, phenol red, neutral red, naphtholphthalein, cresol red, phenolphthalein, thymolphthalein, alkali blue, Alizarin Yellow R, indigo carmine, epsilon blue, or mixtures thereof. 6. The self-sealing barrier composition of claim 1, wherein the at least one absorbent material comprises carboxymethylcellulose, cellulose gums, hydrolyzed acrylonitrile graft copolymer, neutralized starch-acrylic acid graft copolymer, acrylamide copolymer, modified crosslinked polyvinyl alcohol, neutralized self-crosslinking polyacrylic acid, crosslinked polyacrylate salts, neutralized crosslinked isobutylene-maleic anhydride copolymers, or salts or mixtures thereof. 7. The self-sealing barrier composition of claim 1, wherein the at least one plastic comprises a polyolefin, polyamide, polyester, polyurethane, polyacrylonitrile, polycarbonate, polyvinylchloride, polymethylmethacrylate, polyvinylidene fluoride, polytetrafluoroethylene, polyethersulfone, polystyrene, polyether imide, polyetheretherketone, polysulfone, or combinations or copolymers thereof. 8. The self-sealing barrier composition of claim 7, wherein the polyolefin comprises polyethylene, polypropylene, polybutylene, or combinations or copolymers thereof. 9. The self-sealing barrier composition of claim 1, wherein the at least one color change indicator is present in an amount ranging from about 0.001 weight percent to about 2 weight percent of the sintered porous matrix. 10. The self-sealing barrier composition of claim 1, wherein the at least one color change indicator is present in an amount ranging from about 0.05 weight percent to about 0.5 weight percent of the sintered porous matrix. 11. The self-sealing barrier composition of claim 1, wherein the at least one plastic is present in an amount ranging from about 40 weight percent to about 95 weight percent of the sintered porous matrix. 12. The self-sealing barrier composition of claim 1, wherein the sintered porous matrix has an average pore size ranging from about 1 μm an to about 200 μm. 13. The self-sealing barrier composition of claim 1, wherein the sintered porous matrix has a porosity of up to about 90%. 14. The self-sealing barrier composition of claim 1, wherein the self-sealing barrier composition is not responsive to ambient atmospheric moisture. 15. An apparatus comprising: a pipette tip and the self-sealing barrier composition of claim 1, wherein the self-sealing barrier composition of claim 1 is at least partially disposed in the pipette tip. 16. An apparatus comprising: an aspirator, the aspirator comprising a receptacle, an inlet to the receptacle, and an outlet to the receptacle, wherein the self-sealing barrier composition of claim 1 at least partially covers the outlet of the receptacle. 17. An analytical device comprising: a liquid sample collection chamber comprising a sample inlet and the self-sealing barrier composition of claim 1 disposed within the sample collection chamber. 18. The self-sealing barrier composition of claim 1, wherein the at least one color change indicator does not comprise inorganic salts. 19. The self-sealing barrier composition of claim 1, wherein the at least one color change indicator does not comprise a conjugate or complex that changes color upon the binding of an analyte. 20. The self-sealing barrier composition of claim 1, wherein the at least one color change indicator does not comprise proteins or other biological molecules. 21. A self-sealing barrier composition comprising: a sintered porous matrix, the sintered porous matrix comprising at least one self-sealing layer and at least one indicator layer, wherein the self-sealing layer comprises at least one absorbent material and the indicator layer comprises particles of at least one color change indicator, wherein the particles of the at least one color change indicator in the indicator layer dissolve upon contact with liquid and at least partially change the color of the indicator layer, and the self-sealing layer is self-sealing upon contact with the liquid. 22. The self-sealing barrier composition of claim 21, wherein the at least one color change indicator comprises an organic dye, food grade dye, or mixtures thereof. 23. The self-sealing barrier composition of claim 22, wherein the color change indicator comprises FD&C Blue No. 1, FD&C Blue No. 2, FD&C Green No. 3, FD&C Red No. 40, FD&C Red No. 3, FD&C Yellow No. 5, FD&C Yellow No. 6, Solvent Red 24, Solvent Red 26, Solvent Red 164, Solvent Yellow 124, Solvent Blue 35, or mixtures thereof. 24. The self-sealing barrier composition of claim 21, wherein the self-sealing layer is adjacent to the indicator layer. 25. The self-sealing barrier composition of claim 21, wherein the self-sealing layer is spaced apart from the indicator layer. 26. The self-sealing barrier composition of claim 21, wherein the self-sealing layer further comprises a second color change indicator. 27. The self-sealing barrier composition of claim 26, wherein the second color change indicator is different than the color change indicator of the indicator layer. 28. The self-sealing barrier composition of claim 21, wherein the self-sealing layer further comprises at least one plastic. 29. A self-sealing barrier composition comprising: a sintered porous matrix, the sintered porous matrix comprising a self-sealing surface and an indicator surface in facing opposition to the self-sealing surface wherein the self-sealing surface comprises at least one absorbent material and the indicator surface comprises particles of at least one color change indicator, wherein the particles of the at least one color change indicator in the indicator surface dissolve upon contact with liquid and at least partially change the color of the indicator surface, and the self-sealing surface is self-sealing upon contact with the liquid. 30. A hydrophobic barrier composition comprising: a sintered porous matrix, the sintered porous matrix comprising at least one plastic and particles of at least one color change indicator, wherein the hydrophobic barrier composition is substantially free of any absorbent material, wherein the particles of the at least one color change indicator in the sintered porous matrix dissolve upon contact with liquid and at least partially change the color of the sintered porous matrix, and the sintered porous matrix inhibits the liquid from passing through the hydrophobic barrier composition upon contact with the liquid. 31. The hydrophobic barrier composition of claim 30, wherein the at least one color change indicator comprises an organic dye, food grade dye, or mixtures thereof. 32. The hydrophobic barrier composition of claim 31, wherein the color change indicator comprises FD&C Blue No. 1, FD&C Blue No. 2, FD&C Green No. 3, FD&C Red No. 40, FD&C Red No. 3, FD&C Yellow No. 5, FD&C Yellow No. 6, Solvent Red 24, Solvent Red 26, Solvent Red 164, Solvent Yellow 124, Solvent Blue 35, or mixtures thereof. 33. The hydrophobic barrier composition of claim 30, wherein the color change indicator is responsive to pH. 34. The hydrophobic barrier composition of claim 33, wherein the color change indicator comprises methyl violet, eosin yellow, malachite green, thymol blue, methyl yellow, bromophenol blue, congo red, methyl orange, bromocresol green, methyl red, litmus, bromocresol purple, bromophenol red, bromothymol blue, phenol red, neutral red, naphtholphthalein, cresol red, phenolphthalein, thymolphthalein, alkali blue, Alizarin Yellow R, indigo carmine, epsilon blue, or mixtures thereof. 35. The hydrophobic barrier composition of claim 30, wherein the at least one color change indicator is present in an amount ranging from about 0.001 weight percent to about 2 weight percent of the sintered porous matrix. 36. The hydrophobic barrier composition of claim 30, wherein the at least one color change indicator is present in an amount ranging from about 0.05 weight percent to about 0.5 weight percent of the sintered porous matrix. 37. The hydrophobic barrier composition of claim 30, wherein the sintered porous matrix has an average pore size ranging from about 1 μm to about 200 μm. 38. A hydrophilic composition comprising: a sintered porous matrix, the sintered porous matrix comprising at least one plastic, particles of at least one color change indicator, and at least one surfactant, wherein the particles of the at least one color change indicator dissolve upon contact with liquid and at least partially change the color of the sintered porous matrix. 39. The hydrophilic composition of claim 38, wherein the at least one surfactant comprises anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants, or mixtures thereof. 40. The hydrophilic composition of claim 38, wherein the at least one surfactant is present in an amount ranging from about 0.001 weight percent to about 3 weight percent of the sintered porous matrix. 41. A method of making a self-sealing barrier composition comprising: providing particles of at least one plastic;providing particles of at least one absorbent material;providing particles of at least one color change indicator; andcosintering the particles of the at least one plastic, the particles of the at least one absorbent material, and the particles of the at least one color change indicator to form the self-sealing barrier composition, wherein the particles of the at least one color change indicator dissolve upon contact with liquid and the self-sealing barrier composition at least partially changes color and is self-sealing upon contact with the liquid. 42. The method of claim 41, further comprising mixing the particles of the at least one plastic, the particles of the at least one absorbent material, and the particles of the at least one color change indicator to form a substantially uniform mixture. 43. The method of claim 41, wherein the particles of the at least one plastic have an average diameter ranging from about 1 μm to about 500 μm. 44. A hydrophobic barrier composition comprising: a sintered porous matrix, the sintered porous matrix comprising at least one plastic and at particles of least one color change indicator, wherein the particles of the at least one color change indicator in the sintered porous matrix dissolve upon contact with liquid and at least partially change the color of the sintered porous matrix, and the sintered porous matrix inhibits the liquid from passing through the hydrophobic barrier composition upon contact with the liquid.