Cross-linked gelatin composition comprising a wetting agent
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-013/00
A61K-009/70
A61L-015/16
A61L-015/00
출원번호
US-0068812
(2002-02-04)
등록번호
US-8187625
(2012-05-29)
발명자
/ 주소
Greff, Richard J.
출원인 / 주소
Boston Scientific Scimed, Inc.
대리인 / 주소
Seager, Tufte & Wickhem LLC
인용정보
피인용 횟수 :
1인용 특허 :
168
초록
Disclosed is a biocompatible, hemostatic, cross-linked gelatin composition comprising a biocompatible material comprising cross-linked gelatin and a sufficient amount of wetting agent to permit uniform wetting of the sponge in the presence of an aqueous solution.
대표청구항▼
1. A biocompatible, hemostatic, cross-linked gelatin composition comprising: a preformed cross-linked gelatin sponge; anda wetting agent;wherein the wetting agent decreases hydration time of the gelatin sponge and the wetting agent is soluble in a non-aqueous solvent;wherein the wetting agent is coa
1. A biocompatible, hemostatic, cross-linked gelatin composition comprising: a preformed cross-linked gelatin sponge; anda wetting agent;wherein the wetting agent decreases hydration time of the gelatin sponge and the wetting agent is soluble in a non-aqueous solvent;wherein the wetting agent is coated on at least a substantial portion of the surface of the preformed gelatin sponge by soaking the preformed gelatin sponge in a coating solution including the wetting agent and the non-aqueous solvent. 2. The biocompatible, hemostatic, cross-linked gelatin composition of claim 1, wherein the gelatin composition is bioabsorbable. 3. The biocompatible, hemostatic, cross-linked gelatin composition of claim 1, wherein the wetting agent is an anionic wetting agent. 4. The biocompatible, hemostatic, cross-linked gelatin composition of claim 1, wherein the wetting agent is selected from the group consisting of ether capped polyoxyalkylenes, ester capped polyoxyalkylenes, polyethylene oxides, carboxymethyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone, sorbitan esters, phosphatides, alkyl amines, and glycerin. 5. The biocompatible, hemostatic, cross-linked gelatin composition of claim 1, wherein the wetting agent is selected from the group consisting of alkyl (C6-C20) sulfate salts, aryl (C6-C10) sulfate salts, and alkaryl (C7C24) sulfate salts. 6. The biocompatible, hemostatic, cross-linked gelatin composition of claim 1, wherein the gelatin composition comprises from about 0.01 to about 5 weight percent of the wetting agent. 7. The biocompatible, hemostatic, cross-linked gelatin composition of claim 1, wherein the solvent from the coating solution is thereafter evaporated. 8. The biocompatible, hemostatic, cross-linked gelatin composition of claim 1, wherein the coating solution comprises from about 0.01 to about 20 weight percent of the wetting agent. 9. The biocompatible, hemostatic, cross-linked gelatin composition of claim 1, wherein the gelatin composition is sterilized and packaged for use in surgical procedures. 10. The biocompatible, hemostatic, cross-linked gelatin of claim 1, wherein the gelatin composition further comprises a growth factor. 11. The biocompatible, hemostatic, cross-linked gelatin of claim 1, wherein the gelatin composition further comprises a thrombus enhancing agent. 12. The biocompatible, hemostatic, cross-linked gelatin of claim 1, wherein the gelatin composition further comprises an antimicrobial agent. 13. The biocompatible, hemostatic, cross-linked gelatin composition of claim 1, wherein the wetting agent is selected from a group consisting of polyoxyalkylenes.
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