A dry powder inhaler has a vibrator coupled to a blister filled with a dry powder drug substance. One or more of drug ejection apertures in the blister are substantially opposite the vibrator. One or more air intake apertures in the blister are not opposite the vibrator. Upon vibration of the vibrat
A dry powder inhaler has a vibrator coupled to a blister filled with a dry powder drug substance. One or more of drug ejection apertures in the blister are substantially opposite the vibrator. One or more air intake apertures in the blister are not opposite the vibrator. Upon vibration of the vibrator, the drug substance is deaggregated, aerosolized, and ejected from the drug ejection apertures for inhalation by a patient.
대표청구항▼
1. An dry powder inhaler, comprising: an inhaler body including a space for accommodating a container containing a dry powder, a vibratory element, a flow channel, and electronic circuitry to electrically drive the vibratory element, wherein said container has a flat bottom wall, a top wall and a si
1. An dry powder inhaler, comprising: an inhaler body including a space for accommodating a container containing a dry powder, a vibratory element, a flow channel, and electronic circuitry to electrically drive the vibratory element, wherein said container has a flat bottom wall, a top wall and a side wall bridging the top wall and the bottom wall;at least one drug substance ejection aperture in the top wall of said container; andat least one air intake aperture in the side wall of said container;wherein said vibratory element has a flat surface adapted to couple to the flat bottom of said container to vibrate said container and to eject said drug substance from said container through said at least one drug substance ejection aperture and into said flow channel adapted to be inhaled by a patient. 2. The inhaler as in claim 1, wherein said drug substance is deaggregated and aerosolized when ejected from said container. 3. The inhaler as in claim 1, wherein said drug substance is ejected from said container through synthetic jetting. 4. The inhaler as in claim 1, wherein said container is sized to empty of said drug substance in less than approximately 2 seconds. 5. The inhaler as in claim 1, wherein said drug substance is ejected from said container with gravimetric clearance from approximately 80% of said drug substance to approximately 100% of said drug substance. 6. The inhaler as in claim 1, wherein said drug substance is present in said container in quantity from approximately 1 mg to approximately 100 mg. 7. The inhaler as in claim 1, wherein said drug substance is selected from the group consisting of a drug powder, a mixture of a drug powder with an excipient, a mixture of two or more pharmaceutically active drug powder materials, a mixture of two or more pharmaceutically active drug powder materials with an excipient, and a combination thereof. 8. The inhaler as in claim 1, wherein said at least one air intake aperture is round and has a diameter from about 25 microns to about 400 microns. 9. The inhaler as in claim 1, wherein said at least one air intake aperture is round, triangular, square, or polygonal in shape. 10. The inhaler as in claim 1, wherein said container comprises a foil blister, a foil pouch, a plastic blister, or a combination thereof. 11. The inhaler as in claim 1, wherein said container is reusable. 12. The inhaler as in claim 1, wherein said container is formed from a metal, a metal foil, a polymer-coated metal foil, a polymer film, a barrier coated polymer film, a polymer, a polymer laminate, and a combination thereof. 13. The inhaler as in claim 1, wherein said vibratory element is a piezo actuator, a piezo transducer, or a piezo vibrator. 14. The inhaler as in claim 1, further comprising a driver for driving said vibratory element to vibrate at ultrasonic frequencies. 15. The inhaler as in claim 1, wherein said container has one air intake aperture and four drug substance ejection apertures. 16. The inhaler as in claim 1, having at least two apertures in the top wall of the container. 17. The inhaler as in claim 1, wherein said at least one aperture in the top wall of the container is in communication with an air stream in said flow channel adapted to be inhaled by a patient, wherein upon vibrating said drug is ejected from said at least one aperture in the top wall and picked up by said air stream adapted to be inhaled by said patient. 18. The inhaler as in claim 1, wherein the total area of ejection aperture(s) in the top wall of the container is at least two times the total area of our intake aperture(s) in the side wall(s) of the container. 19. The inhaler as in claim 18, wherein the total area of ejection aperture(s) in the top wall of the container is at least five times the total area of air intake aperture(s) in the side wall(s) of the container.
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