IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0117601
(2008-05-08)
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등록번호 |
US-8197828
(2012-06-12)
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발명자
/ 주소 |
- Van, Sang
- Song, Yucheng
- Wang, Xinghe
- Hou, Zheng
- Feng, Zhongling
- Zhao, Gang
- Yu, Lei
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출원인 / 주소 |
|
대리인 / 주소 |
Knobbe, Martens, Olson & Bear LLP
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인용정보 |
피인용 횟수 :
0 인용 특허 :
77 |
초록
Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.
대표청구항
▼
1. A composition comprising a first hydrophobic drug, a second hydrophobic drug and a polymer conjugate, wherein: the polymer conjugate comprises a polymeric matrix that non-covalently entraps at least a portion of the first hydrophobic drug therein;the polymer conjugate comprises a recurring unit o
1. A composition comprising a first hydrophobic drug, a second hydrophobic drug and a polymer conjugate, wherein: the polymer conjugate comprises a polymeric matrix that non-covalently entraps at least a portion of the first hydrophobic drug therein;the polymer conjugate comprises a recurring unit of the formula (I): wherein n is 1 or 2;each A1 is independently oxygen or NR5, where R5 is hydrogen or C1-4 alkyl; andat least one of R1 and R2 is a group that comprises the second hydrophobic drug, wherein if only one of R1 and R2 is the group that comprises the second hydrophobic drug, the other one of R1 and R2 is selected from the group consisting of hydrogen, a C1-10 alkyl group, a C6-20 aryl group, an ammonium group, an alkali metal, a polydentate ligand, a polydentate ligand precursor with protected oxygen atoms, a group that comprises a targeting agent, a group that comprises an optical imaging agent, a group that comprises a magnetic resonance imaging agent, and a group that comprises a stabilizing agent. 2. The composition of claim 1, wherein the polymer conjugate further comprises a recurring unit of the formula (II): wherein m is 1 or 2;each A2 is independently oxygen or NR6, where R6 is hydrogen or C1-4 alkyl; andR3 and R4 are each independently selected from the group consisting of hydrogen, ammonium, and an alkali metal. 3. The composition of claim 1, wherein the polymer conjugate further comprises a recurring unit of the formula (III): wherein R7 is hydrogen, ammonium, or an alkali metal. 4. The composition of claim 1, wherein the first hydrophobic drug has a chemical structure that is different from that of the second hydrophobic drug. 5. The composition of claim 1, wherein the first hydrophobic drug has a chemical structure that is the same as that of the second hydrophobic drug. 6. The composition of claim 1, wherein at least one of the first hydrophobic drug and the second hydrophobic drug is an anticancer drug. 7. The composition of claim 6, wherein the anticancer drug is selected from the group consisting of a taxane, a camptotheca, and an anthracycline. 8. The composition of claim 6, wherein the anticancer drug is selected from the group consisting of paclitaxel, docetaxel, camptothecin and doxorubicin. 9. The composition of claim 1, wherein the polymer conjugate comprises an amount of the second hydrophobic drug in the range of about 1% to about 50% (weight/weight) based on the mass ratio of the second hydrophobic drug to the combined weight of the first hydrophobic drug and the polymer conjugate. 10. The composition of claim 1, wherein the first hydrophobic drug is present in an amount in the range of about 1% to about 50% (weight/weight) based on the mass ratio of the first hydrophobic drug to the combined weight of the first hydrophobic drug and the polymer conjugate. 11. The composition of claim 1, wherein the targeting agent is selected from the group consisting of an arginine-glycine-aspartate (RGD) peptide, fibronectin, folate, galactose, an apolipoprotein, insulin, transferrin, a fibroblast growth factor (FGF), an epidermal growth factor (EGF), and an antibody. 12. The composition of claim 1, wherein the optical imaging agent is selected from the group consisting of an acridine dye, a coumarine dye, a rhodamine dye, a xanthene dye, a cyanine dye, and a pyrene dye. 13. The composition of claim 1, wherein the magnetic resonance imaging agent comprises a Gd(III) compound. 14. The composition of claim 13, wherein the Gd(III) compound comprises: 15. The composition of claim 1, wherein the polydentate ligand comprises: wherein each R9 is independently selected from the group consisting of hydrogen, ammonium, and an alkali metal; and wherein each R10 is independently selected from the group consisting of hydrogen, ammonium, and an alkali metal. 16. The composition of claim 1, wherein the polydentate ligand precursor with protected oxygen atoms comprises: 17. The composition of claim 1, wherein the stabilizing agent is polyethylene glycol. 18. A method of making the composition of claim 1, comprising the steps of: at least partially dissolving the polymer conjugate in a solvent; andintermixing the first hydrophobic drug with the at least partially dissolved polymer conjugate to form a mixture. 19. The method of claim 18, wherein the intermixing comprises mixing a solution of the first hydrophobic drug with the at least partially dissolved polymer conjugate to form the mixture. 20. A method of treating, ameliorating or diagnosing a disease or condition, comprising administering an effective amount of the composition of claim 1 to a mammal in need thereof. 21. The method of claim 20, wherein the disease or condition is selected from the group consisting of lung cancer, breast cancer, colon cancer, ovarian cancer, prostate cancer, and melanoma. 22. The method of claim 20, wherein the composition is administered intravenously. 23. The composition of claim 1, wherein the first hydrophobic drug is present in an amount in the range of about 5% to about 40% (weight/weight) based on the mass ratio of the first hydrophobic drug to the combined weight of the first hydrophobic drug and the polymer conjugate.
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