Blocking exogenous action potentials by an implantable medical device
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A63B-021/00
A61N-001/18
출원번호
US-0109467
(2008-04-25)
등록번호
US-8204603
(2012-06-19)
발명자
/ 주소
Maschino, Steven E.
출원인 / 주소
Cyberonics, Inc.
대리인 / 주소
Cyberonics, Inc.
인용정보
피인용 횟수 :
3인용 특허 :
207
초록▼
An implantable medical device (IMD) to treat a medical condition in a patient comprises an electrical signal generator; a cathode and an anode operatively coupled to the electrical signal generator and a cranial nerve of the patient; and a third electrode operatively coupled to the electrical signal
An implantable medical device (IMD) to treat a medical condition in a patient comprises an electrical signal generator; a cathode and an anode operatively coupled to the electrical signal generator and a cranial nerve of the patient; and a third electrode operatively coupled to the electrical signal generator and implanted within the patient's body; wherein the electrical signal generator is capable of generating and delivering at least one electrical signal effective at the anode to block at least a sufficient portion of action potentials induced by the at least one electrical signal in the cranial nerve proximate the cathode to reduce a side effect of said induced action potentials.
대표청구항▼
1. An implantable medical device to treat a medical condition in a patient, the implantable medical device comprising: a cathode and an anode configured to be coupled to an electrical signal generator and to be coupled to a cranial nerve of the patient;a third electrode configured to be implanted wi
1. An implantable medical device to treat a medical condition in a patient, the implantable medical device comprising: a cathode and an anode configured to be coupled to an electrical signal generator and to be coupled to a cranial nerve of the patient;a third electrode configured to be implanted within the patient and configured to be coupled to the electrical signal generator;wherein the electrical signal generator is configured to deliver a first electrical signal to the cathode and to the anode during a first time period, wherein the first electrical signal causes depolarization of a first portion of the cranial nerve proximate to the cathode and causes hyperpolarization of a second portion of the cranial nerve proximate to the anode, andwherein the electrical signal generator is configured to deliver a second electrical signal to the anode and to the third electrode during a second time period following the first time period, wherein the hyperpolarization of the second portion of the cranial nerve caused by the first electrical signal persists when the second electrical signal is delivered and delivery of the second electrical signal continues the hyperpolarization of the second portion of the cranial nerve. 2. The implantable medical device of claim 1, wherein delivery of the second electrical signal is effective to inhibit one or more side effects associated with depolarization of the first portion of the cranial nerve. 3. The implantable medical device of claim 2, wherein the one or more side effects include at least one of vocal cord modulation, breathing difficulty, shortness of breath, apnea, dyspnea, and impairment of at least one quality of the patient's voice. 4. The implantable medical device of claim 1, wherein the third electrode is not coupled to the cranial nerve. 5. The implantable medical device of claim 1, wherein the third electrode is a shell of the electrical signal generator. 6. The implantable medical device of claim 1, wherein the cranial nerve is a vagus nerve. 7. The implantable medical device of claim 5, wherein current density associated with at least one of the first electrical signal and the second electrical signal proximate the third electrode is reduced relative to a corresponding current density proximate the anode and the cathode. 8. A method of treating a medical condition in a patient using an implantable medical device, the method comprising: delivering a first electrical signal during a first time period to a cathode and an anode of the implantable medical device, wherein the implantable medical device is coupled to a cranial nerve of the patient, wherein the first electrical signal causes depolarization of a first portion of the cranial nerve proximate to the cathode and causes hyperpolarization of a second portion of the cranial nerve proximate to the anode, anddelivering a second electrical signal to the anode and to a third electrode of the implantable medical device during a second time period following the first time period, wherein the hyperpolarization of the second portion of the cranial nerve caused by the first electrical signal persists when the second electrical signal is delivered and delivery of the second electrical signal continues the hyperpolarization of the second portion of the cranial nerve. 9. The method of claim 8, wherein the hyperpolarization of the second portion of the cranial nerve during the first time period and during the second time period is effective to block at least a portion of endogenous action potentials at the second portion of the cranial nerve and to block at least a portion of action potentials induced by the depolarization caused by the first electrical signal. 10. The method of claim 8, wherein the depolarization of the first portion of the cranial nerve induces action potentials at the first portion of the cranial nerve, wherein the action potentials are inhibited, by the hyperpolarization of the second portion of the cranial nerve, from propagating in one or more nerve fiber types of the cranial nerve, wherein the one or more nerve fiber types include at least one of Aα fibers, Aβ fibers, Aγ fibers, Aδ fibers, B fibers, and C fibers. 11. The method of claim 10, wherein the action potentials are efferent action potentials. 12. The method of claim 8, wherein the third electrode is a shell of the implantable medical device. 13. The method of claim 8, wherein delivery of the second electrical signal is effective to block action potentials that would, if unblocked, propagate towards one or more body structures of the patient that are innervated by the cranial nerve, the blocking of the action potentials reducing one or more side effects occurring at the one or more body structures of the patient. 14. The method of claim 8, wherein a duration of the depolarization proximate to the cathode is from about 0.01 msec to about 1 msec. 15. The method of claim 8, further comprising balancing charge by passive discharge from at least one of the cathode and the anode. 16. The method of claim 15, wherein passive discharge is performed at both the cathode and the anode. 17. The method of claim 8, further comprising balancing charge by active discharge from at least one of the cathode and the anode. 18. The method of claim 17, wherein active discharge is performed at both the cathode and the anode. 19. A method comprising: delivering a first electrical signal during a first time period to an anode and a cathode of an implantable medical device coupled to a cranial nerve of a patient, wherein the first electrical signal causes depolarization of a first portion of the cranial nerve proximate to the cathode and causes hyperpolarization of a second portion of the cranial nerve proximate to the anode, anddelivering a second electrical signal to the anode and to a third electrode of the implantable medical device during a second time period following the first time period, wherein the hyperpolarization of the second portion of the cranial nerve caused by the first electrical signal persists when the second electrical signal is delivered, and wherein delivery of the second electrical signal is effective to block action potentials that would, if unblocked, stimulate muscle activity proximate to a larynx of the patient. 20. A system comprising: a cathode and an anode configured to be coupled to an electrical signal generator and to be coupled to a cranial nerve of a patient;an electrode configured to be implanted within the patient and to be coupled to the electrical signal generator;wherein the electrical signal generator is configured to deliver a first electrical signal to the anode and the cathode during a first time period, wherein the first electrical signal causes depolarization of a first portion of the cranial nerve proximate to the cathode and causes hyperpolarization of a second portion of the cranial nerve proximate to the anode;wherein the electrical signal generator is configured to deliver a second electrical signal to the anode and to the electrode during a second time period following the first time period, wherein the hyperpolarization of the second portion of the cranial nerve caused by the first electrical signal persists when the second electrical signal is delivered, and wherein delivery of the second electrical signal is effective to block action potentials that would, if unblocked, stimulate muscle activity proximate to a larynx of the patient. 21. The system of claim 20, further comprising a switching controller to control delivery and duration of the first electrical signal to the anode and the cathode, and to control delivery and duration of the second electrical signal to the anode and the electrode.
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