System and method for monitoring health using exhaled breath
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/08
A61M-031/00
출원번호
US-0512856
(2006-08-29)
등록번호
US-8211035
(2012-07-03)
발명자
/ 주소
Melker, Richard J.
Bjoraker, David G.
Lampotang, Samsun
출원인 / 주소
University of Florida Research Foundation, Inc.
대리인 / 주소
Thomas, Kayden, Horstemeyer & Risley, LLP
인용정보
피인용 횟수 :
13인용 특허 :
154
초록▼
The present invention includes systems and methods for monitoring endogenous compound concentration in blood by detecting markers, such as odors, upon exhalation by a patient, wherein such markers are the endogenous compound itself or result from the endogenous compound. In the case of olfactory mar
The present invention includes systems and methods for monitoring endogenous compound concentration in blood by detecting markers, such as odors, upon exhalation by a patient, wherein such markers are the endogenous compound itself or result from the endogenous compound. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor endogenous compound levels in blood. The invention further includes a reporting system capable of tracking endogenous compound concentrations in blood (remote or proximate locations) and providing the necessary alerts with regard to emergent or harmful conditions in a patient.
대표청구항▼
1. An anesthetic agent delivery system or apparatus for intravenously delivering a desired dose of anesthetic agent to a patient comprising: (a) an intravenous anesthetic supply;(b) a breath analyzer for analyzing the patient's breath for concentration of at least one substance, selected from the gr
1. An anesthetic agent delivery system or apparatus for intravenously delivering a desired dose of anesthetic agent to a patient comprising: (a) an intravenous anesthetic supply;(b) a breath analyzer for analyzing the patient's breath for concentration of at least one substance, selected from the group consisting of the active anesthetic agent itself or a metabolite thereof, indicative of the anesthetic agent concentration in the patient's bloodstream, and for providing a signal to indicate the anesthetic agent concentration delivered to the patient; and(c) a system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent based on the signal. 2. The system or apparatus of claim 1 wherein the breath analyzer comprises a collector for sampling the patient's expired breath, a sensor for analyzing the breath for concentration of at least one substance indicative of the anesthetic agent concentration, a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 3. The system or apparatus of claim 2 wherein the sensor is selected from semiconductor gas sensor technology, surface acoustic wave gas sensor technology or conductive polymer gas sensor technology. 4. The system or apparatus of claim 1, further comprising respiratory phase sensor technology for determining a specific phase of the respiratory cycle from which the sample of breath is collected. 5. The system or apparatus of claim 4, wherein said respiratory phase sensor technology is selected from the group consisting of: viscosity sensors; flow sensors; pressure sensors; humidity sensors;temperature sensors; and gas sensors. 6. The system or apparatus of claim 5, wherein said respiratory phase sensor technology is selected from the group consisting of: CO2 sensors; O2 sensors; and NO sensors. 7. The system or apparatus of claim 4, wherein the sample of breath is collected from the initial phase or end-tidal phase. 8. The system or apparatus according to claim 1 wherein said anesthetic agent supply comprises an anesthetic gas supply in addition to said intravenous agent supply. 9. The system or apparatus according to claim 8 comprising both an anesthetic gas supply and an intravenous agent supply, and wherein said controller controls the amount of anesthetic gas supply to a breathing circuit including said patient, said controller controls the amount of intravenous agent administered to the patient intravenously, or both, or wherein separate controllers control the amount of said anesthetic gas supply to a breathing circuit including said patient and the amount of intravenous agent administered to the patient intravenously. 10. The system or apparatus according to claim 8 further comprising an inspired gas analyzer for analyzing the concentration of anesthetic gas in the breathing circuit. 11. The system or apparatus according to claim 10 wherein said controller is connected to both an intravenous anesthetic supply and an anesthetic gas supply and which receives signals from both an inspired gas analyzer and an expired gas analyzer and controls the amount of anesthetic agents administered based on the signals or wherein a first controller receives a signal from an inspired gas analyzer and a second controller receives a signal from an expired gas analyzer, and each of said first and second controllers control the amount of anesthetic agent delivered to a patient based on said signals. 12. The system or apparatus of claim 11 wherein the inspired gas analyzer and expired gas analyzer each comprise a sensor for analyzing the gas for concentration of at least one substance indicative of anesthetic agent concentration and a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 13. The system or apparatus of claim 12 wherein the sensor is selected from semiconductor gas sensor technology, surface acoustic wave gas sensor technology or conductive polymer gas sensor technology and further, optionally comprising: respiratory phase sensor technology for determining a specific phase of the respiratory cycle from which the sample of breath is collected, and the sample of breath is collected from the initial phase or end-tidal phase. 14. The system or apparatus according to claim 1 for intravenously delivering a desired dose of anesthetic agent to a patient comprising: an intravenous anesthetic supply having a controller for controlling the amount of anesthetic agent provided intravenously by the supply;a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the free anesthetic agent concentration in the patient's bloodstream that provides a signal to indicate the free anesthetic agent concentration produced by the anesthetic agent intravenously delivered to the patient; anda system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent delivered intravenously based on the signal. 15. The system or apparatus of claim 14 wherein the breath analyzer comprises a collector for sampling the patient's expired breath, a sensor for analyzing the breath for concentration of at least one substance indicative of the free anesthetic agent concentration in the patient's blood, a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 16. The system or apparatus of claim 15 wherein the sensor is selected from semiconductor gas sensor technology, conductive polymer gas sensor technology, or surface acoustic wave gas sensor technology. 17. The system or apparatus according to claim 14 wherein said anesthetic agent is selected from the group comprising Remifentanil and Propofol. 18. The system or apparatus of claim 14 wherein the breath analyzer comprises a collector for sampling the patient's expired breath, and a sensor for analyzing the breath for concentration of at least one substance indicative of the free anesthetic agent concentration in the patient's blood. 19. The system or apparatus according to claim 1 for measuring the free concentration in blood of a patient of an intravenously administered anesthetic comprising: a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the anesthetic agent in the patient's bloodstream. 20. The system or apparatus according to claim 19 wherein said anesthetic is selected from the group comprising Remifentanil and Propofol. 21. The apparatus according to claim 19 further comprising a means for determining the fraction of the breath collected for analysis such that any particular breath fraction may be collected, including the only the end tidal breath fraction. 22. An anesthetic agent delivery system or apparatus for delivering a desired dose of anesthetic agent to a patient comprising: (a) an anesthetic supply;(b) a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the anesthetic agent concentration in the patient's bloodstream, and for providing a signal to indicate the anesthetic agent concentration delivered to the patient; and(c) a system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent based on the signal;wherein the breath analyzer comprises a collector for sampling the patient's expired breath, a sensor for analyzing the breath for concentration of at least one substance indicative of the anesthetic agent concentration, a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 23. The system or apparatus of claim 22 wherein the sensor is selected from semiconductor gas sensor technology, surface acoustic wave gas sensor technology or conductive polymer gas sensor technology. 24. An anesthetic agent delivery system or apparatus for delivering a desired dose of anesthetic agent to a patient comprising: (a) an anesthetic supply;(b) a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the anesthetic agent concentration in the patient's bloodstream, and for providing a signal to indicate the anesthetic agent concentration delivered to the patient; and(c) a system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent based on the signal;wherein said anesthetic agent supply comprises an anesthetic gas supply, an intravenous agent supply;further comprising an inspired gas analyzer for analyzing the concentration of anesthetic gas in the breathing circuit;wherein said controller is connected to both an intravenous anesthetic supply and an anesthetic gas supply and which receives signals from both an inspired gas analyzer and an expired gas analyzer and controls the amount of anesthetic agents administered based on the signals or wherein a first controller receives a signal from an inspired gas analyzer and a second controller receives a signal from an expired gas analyzer, and each of said first and second controllers control the amount of anesthetic agent delivered to a patient based on said signals;wherein the inspired gas analyzer and expired gas analyzer each comprise a sensor for analyzing the gas for concentration of at least one substance indicative of anesthetic agent concentration and a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 25. The system or apparatus of claim 24 wherein the sensor is selected from semiconductor gas sensor technology, surface acoustic wave gas sensor technology or conductive polymer gas sensor technology and further, optionally comprising: respiratory phase sensor technology for determining a specific phase of the respiratory cycle from which the sample of breath is collected, and the sample of breath is collected from the initial phase or end-tidal phase. 26. An anesthetic agent delivery system or apparatus for delivering a desired dose of anesthetic agent to a patient comprising: (a) an anesthetic supply;(b) a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the anesthetic agent concentration in the patient's bloodstream, and for providing a signal to indicate the anesthetic agent concentration delivered to the patient; and(c) a system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent based on the signal;said system for intravenously delivering a desired dose of anesthetic agent to a patient comprising:an intravenous anesthetic supply having a controller for controlling the amount of anesthetic agent provided intravenously by the supply;a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the free anesthetic agent concentration in the patient's bloodstream that provides a signal to indicate the free anesthetic agent concentration produced by the anesthetic agent intravenously delivered to the patient; anda system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent delivered intravenously based on the signal;wherein the breath analyzer comprises a collector for sampling the patient's expired breath, a sensor for analyzing the breath for concentration of at least one substance indicative of the free anesthetic agent concentration in the patient's blood, a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 27. The system or apparatus of claim 25 wherein the sensor is selected from semiconductor gas sensor technology, conductive polymer gas sensor technology, or surface acoustic wave gas sensor technology.
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Heim Werner (Herrenberg DEX) Koeninger Joachim (Eutingen DEX) Hickl Christian (Stuttgart DEX), Anesthesia protocol system and method of controlling the same.
Westenskow Dwayne D. (Salt Lake City UT) Loughlin Patrick J. (Seattle WA) Jaklitsch Roman R. (Lbeck DEX) Wallroth Carl-Friedrich (Lbeck DEX), Anesthesia ventilating apparatus having a breathing circuit and control loops for anesthetic gas components.
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Andrews Thomas W. ; Guzzi Louis M. ; Hartson David P. ; Riley James L., Apparatus and method for total intravenous anesthesia delivery and associated patient monitoring.
Cosentino, Daniel L.; Cosentino, Louis C.; Dorfe, Steven George; Duea, Duane Robert, Apparatus and method for two-way communication in a device for monitoring and communicating wellness parameters of ambulatory patients.
Cooper David E. (Palo Alto CA) Carlisle Clinton B. (Menlo Park CA) Riris Haris (Menlo Park CA), Diagnostic tests using near-infrared laser absorption spectroscopy.
Park Hyeon S. (Seoul KRX) Lee Kyu C. (Shungcheongbuk-do KRX) Kwon Chul H. (Chungcheongbuk-do KRX) Yun Dong H. (Chungcheongbuk-do KRX) Shin Hyun W. (Chungcheongbuk-do KRX) Hong Hyung K. (Chungcheongbu, Gas sensor and manufacturing method of the same.
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Gargan Paul E. (Southbend IN) Ploplis Victoria A. (Leuven IN BEX) Pleasants Julian R. (Granger IN), Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers.
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Muller Richard S. (51 Kenyon Ave. Kensington CA 94708) White Richard M. (350 Panoramic Way Berkeley CA 94704), Method and apparatus for sensing fluids using surface acoustic waves.
Fisher Murray M. (76 Braeside Road Toronto ; Ontario CAX M4N 1X7), Method employing chemical markers and kit for verifying the source and completeness of urine samples for testing for the.
Daniel Seidman IL, Method for using breath carbon monoxide concentration measurements to detect pregnant women at risk for or experiencing various pathological conditions relating to pregnancy.
Labows John N. (Horsham PA) Kostelc James G. (Glenside PA) McGinley Kenneth J. (Philadelphia PA), Method of detecting Pseudomonas aeruginosa infections utilizing selected ketone and/or sulfur metabolites.
Preti George (Horsham PA) Labows John N. (Horsham PA) Daniele Ronald (Philadelphia PA) Kostelc James G. (Creve Coeur MO), Method of detecting the presence of bronchogenic carcinoma by analysis of expired lung air.
Preti George (Philadelphia PA) Kostelc James G. (Glenside PA) Zelson Philip R. (Drexel Hill PA), Method of diagnosing periodontal disease through the detection of pyridine compounds.
Greenberg Michael J. (Northbrook IL) Johnson Sonya D. (Brookfield IL), Method of stabilizing peptide sweeteners in cinnamon-flavored chewing gums and confections.
Balestrieri Giorgio (New York NY) Kaish Norman (Whitestone NY), Method of tagging and detecting drugs, crops, chemical compounds and currency with perfluorocarbon tracers (PFT\S).
Fitzgerald, Garret A.; Rokach, Joshua; Pratico, Domenico; Trojanowski, John Q., Methods and compositions for determining lipid peroxidation levels in oxidant stress syndromes and diseases.
Bathe Duncan P. L. (Madison WI) Kohlmann Thomas S. (McFarland WI) Pinkert John R. (Madison WI) Tham Robert Q. (Middleton WI), Nitric oxide delivery system.
Kiel Johnathan L. ; Bruno John G. ; Parker Jill E. ; Alls John L. ; Batishko Charles R. ; Holwitt Eric A., Organic semiconductor recognition complex and system.
Cabuz, Cleopatra; Zook, J. David; Cox, James Allen; Ohnstein, Thomas Raymond; Bonne, Ulrich; Cabuz, Eugen Loan; Satren, Ernest Allen; Padmanabhan, Aravind; Marta, Teresa M., Portable flow cytometry.
Snow Michael G. (North St. Paul MN) Tyler William R. (St. Paul MN) Hsu Sung-Peng (Eagan MN) Fallat Robert J. (San Rafael CA), Pulmonary diagnostic system.
Thrall Karla D. (3804 Alder Lake Ct. West Richland WA 99353) Kenny Donald V. (6947 Sparrow La. Worthington OH 43235) Endres George W. R. (2112 Briarwood Ct. Richland WA 99352) Sisk Daniel R. (1211 Ma, Real time chemical exposure and risk monitor.
Lokshin Anatole (Claremont CA) Burchfield David E. (Rancho Cucamonga CA) Tracy David H. (Norwalk CT), Saw vapor sensor apparatus and multicomponent signal processing.
Braig James R. (Oakland CA) Goldberger Daniel S. (Boulder CO) Yelderman Mark L. (Plano TX) Herrera Roger O. (Oakland CA), Shutterless mainstream discriminating anesthetic agent analyzer.
Nathan S. Lewis ; Erik J. Severin ; Michael Freund ; Adam J. Matzger, Use of an array of polymeric sensors of varying thickness for detecting analytes in fluids.
Aker, Craig A.; Cumming, Colin J.; Fisher, Mark E.; Fox, Michael J.; laGrone, Marcus J.; Reust, Dennis K.; Rockley, Mark G.; Towers, Eric S., Vapor sensing instrument for ultra trace chemical detection.
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