초록 ▼

The present invention includes systems and methods for monitoring endogenous compound concentration in blood by detecting markers, such as odors, upon exhalation by a patient, wherein such markers are the endogenous compound itself or result from the endogenous compound. In the case of olfactory mar

The present invention includes systems and methods for monitoring endogenous compound concentration in blood by detecting markers, such as odors, upon exhalation by a patient, wherein such markers are the endogenous compound itself or result from the endogenous compound. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor endogenous compound levels in blood. The invention further includes a reporting system capable of tracking endogenous compound concentrations in blood (remote or proximate locations) and providing the necessary alerts with regard to emergent or harmful conditions in a patient.

대표청구항 ▼

1. An anesthetic agent delivery system or apparatus for intravenously delivering a desired dose of anesthetic agent to a patient comprising: (a) an intravenous anesthetic supply;(b) a breath analyzer for analyzing the patient's breath for concentration of at least one substance, selected from the gr

1. An anesthetic agent delivery system or apparatus for intravenously delivering a desired dose of anesthetic agent to a patient comprising: (a) an intravenous anesthetic supply;(b) a breath analyzer for analyzing the patient's breath for concentration of at least one substance, selected from the group consisting of the active anesthetic agent itself or a metabolite thereof, indicative of the anesthetic agent concentration in the patient's bloodstream, and for providing a signal to indicate the anesthetic agent concentration delivered to the patient; and(c) a system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent based on the signal. 2. The system or apparatus of claim 1 wherein the breath analyzer comprises a collector for sampling the patient's expired breath, a sensor for analyzing the breath for concentration of at least one substance indicative of the anesthetic agent concentration, a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 3. The system or apparatus of claim 2 wherein the sensor is selected from semiconductor gas sensor technology, surface acoustic wave gas sensor technology or conductive polymer gas sensor technology. 4. The system or apparatus of claim 1, further comprising respiratory phase sensor technology for determining a specific phase of the respiratory cycle from which the sample of breath is collected. 5. The system or apparatus of claim 4, wherein said respiratory phase sensor technology is selected from the group consisting of: viscosity sensors; flow sensors; pressure sensors; humidity sensors;temperature sensors; and gas sensors. 6. The system or apparatus of claim 5, wherein said respiratory phase sensor technology is selected from the group consisting of: CO2 sensors; O2 sensors; and NO sensors. 7. The system or apparatus of claim 4, wherein the sample of breath is collected from the initial phase or end-tidal phase. 8. The system or apparatus according to claim 1 wherein said anesthetic agent supply comprises an anesthetic gas supply in addition to said intravenous agent supply. 9. The system or apparatus according to claim 8 comprising both an anesthetic gas supply and an intravenous agent supply, and wherein said controller controls the amount of anesthetic gas supply to a breathing circuit including said patient, said controller controls the amount of intravenous agent administered to the patient intravenously, or both, or wherein separate controllers control the amount of said anesthetic gas supply to a breathing circuit including said patient and the amount of intravenous agent administered to the patient intravenously. 10. The system or apparatus according to claim 8 further comprising an inspired gas analyzer for analyzing the concentration of anesthetic gas in the breathing circuit. 11. The system or apparatus according to claim 10 wherein said controller is connected to both an intravenous anesthetic supply and an anesthetic gas supply and which receives signals from both an inspired gas analyzer and an expired gas analyzer and controls the amount of anesthetic agents administered based on the signals or wherein a first controller receives a signal from an inspired gas analyzer and a second controller receives a signal from an expired gas analyzer, and each of said first and second controllers control the amount of anesthetic agent delivered to a patient based on said signals. 12. The system or apparatus of claim 11 wherein the inspired gas analyzer and expired gas analyzer each comprise a sensor for analyzing the gas for concentration of at least one substance indicative of anesthetic agent concentration and a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 13. The system or apparatus of claim 12 wherein the sensor is selected from semiconductor gas sensor technology, surface acoustic wave gas sensor technology or conductive polymer gas sensor technology and further, optionally comprising: respiratory phase sensor technology for determining a specific phase of the respiratory cycle from which the sample of breath is collected, and the sample of breath is collected from the initial phase or end-tidal phase. 14. The system or apparatus according to claim 1 for intravenously delivering a desired dose of anesthetic agent to a patient comprising: an intravenous anesthetic supply having a controller for controlling the amount of anesthetic agent provided intravenously by the supply;a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the free anesthetic agent concentration in the patient's bloodstream that provides a signal to indicate the free anesthetic agent concentration produced by the anesthetic agent intravenously delivered to the patient; anda system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent delivered intravenously based on the signal. 15. The system or apparatus of claim 14 wherein the breath analyzer comprises a collector for sampling the patient's expired breath, a sensor for analyzing the breath for concentration of at least one substance indicative of the free anesthetic agent concentration in the patient's blood, a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 16. The system or apparatus of claim 15 wherein the sensor is selected from semiconductor gas sensor technology, conductive polymer gas sensor technology, or surface acoustic wave gas sensor technology. 17. The system or apparatus according to claim 14 wherein said anesthetic agent is selected from the group comprising Remifentanil and Propofol. 18. The system or apparatus of claim 14 wherein the breath analyzer comprises a collector for sampling the patient's expired breath, and a sensor for analyzing the breath for concentration of at least one substance indicative of the free anesthetic agent concentration in the patient's blood. 19. The system or apparatus according to claim 1 for measuring the free concentration in blood of a patient of an intravenously administered anesthetic comprising: a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the anesthetic agent in the patient's bloodstream. 20. The system or apparatus according to claim 19 wherein said anesthetic is selected from the group comprising Remifentanil and Propofol. 21. The apparatus according to claim 19 further comprising a means for determining the fraction of the breath collected for analysis such that any particular breath fraction may be collected, including the only the end tidal breath fraction. 22. An anesthetic agent delivery system or apparatus for delivering a desired dose of anesthetic agent to a patient comprising: (a) an anesthetic supply;(b) a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the anesthetic agent concentration in the patient's bloodstream, and for providing a signal to indicate the anesthetic agent concentration delivered to the patient; and(c) a system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent based on the signal;wherein the breath analyzer comprises a collector for sampling the patient's expired breath, a sensor for analyzing the breath for concentration of at least one substance indicative of the anesthetic agent concentration, a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 23. The system or apparatus of claim 22 wherein the sensor is selected from semiconductor gas sensor technology, surface acoustic wave gas sensor technology or conductive polymer gas sensor technology. 24. An anesthetic agent delivery system or apparatus for delivering a desired dose of anesthetic agent to a patient comprising: (a) an anesthetic supply;(b) a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the anesthetic agent concentration in the patient's bloodstream, and for providing a signal to indicate the anesthetic agent concentration delivered to the patient; and(c) a system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent based on the signal;wherein said anesthetic agent supply comprises an anesthetic gas supply, an intravenous agent supply;further comprising an inspired gas analyzer for analyzing the concentration of anesthetic gas in the breathing circuit;wherein said controller is connected to both an intravenous anesthetic supply and an anesthetic gas supply and which receives signals from both an inspired gas analyzer and an expired gas analyzer and controls the amount of anesthetic agents administered based on the signals or wherein a first controller receives a signal from an inspired gas analyzer and a second controller receives a signal from an expired gas analyzer, and each of said first and second controllers control the amount of anesthetic agent delivered to a patient based on said signals;wherein the inspired gas analyzer and expired gas analyzer each comprise a sensor for analyzing the gas for concentration of at least one substance indicative of anesthetic agent concentration and a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 25. The system or apparatus of claim 24 wherein the sensor is selected from semiconductor gas sensor technology, surface acoustic wave gas sensor technology or conductive polymer gas sensor technology and further, optionally comprising: respiratory phase sensor technology for determining a specific phase of the respiratory cycle from which the sample of breath is collected, and the sample of breath is collected from the initial phase or end-tidal phase. 26. An anesthetic agent delivery system or apparatus for delivering a desired dose of anesthetic agent to a patient comprising: (a) an anesthetic supply;(b) a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the anesthetic agent concentration in the patient's bloodstream, and for providing a signal to indicate the anesthetic agent concentration delivered to the patient; and(c) a system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent based on the signal;said system for intravenously delivering a desired dose of anesthetic agent to a patient comprising:an intravenous anesthetic supply having a controller for controlling the amount of anesthetic agent provided intravenously by the supply;a breath analyzer for analyzing the patient's breath for concentration of at least one substance indicative of the free anesthetic agent concentration in the patient's bloodstream that provides a signal to indicate the free anesthetic agent concentration produced by the anesthetic agent intravenously delivered to the patient; anda system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent delivered intravenously based on the signal;wherein the breath analyzer comprises a collector for sampling the patient's expired breath, a sensor for analyzing the breath for concentration of at least one substance indicative of the free anesthetic agent concentration in the patient's blood, a processor for calculating the effect of the agent based on the concentration and determining depth of anesthesia. 27. The system or apparatus of claim 25 wherein the sensor is selected from semiconductor gas sensor technology, conductive polymer gas sensor technology, or surface acoustic wave gas sensor technology.