IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0126101
(2005-05-10)
|
등록번호 |
US-8211060
(2012-07-03)
|
발명자
/ 주소 |
|
출원인 / 주소 |
- Palyon Medical (BVI) Limited
|
대리인 / 주소 |
Lerner, David, Littenberg, Krumholz & Mentlik, LLP
|
인용정보 |
피인용 횟수 :
5 인용 특허 :
121 |
초록
▼
A variable hydraulic resistor for use with implantable pumps is disclosed. The variable hydraulic resistor according to the present invention is particularly useful in varying the flow rate of a medication fluid from an otherwise constant flow implantable pump. An implantable pump is also disclosed,
A variable hydraulic resistor for use with implantable pumps is disclosed. The variable hydraulic resistor according to the present invention is particularly useful in varying the flow rate of a medication fluid from an otherwise constant flow implantable pump. An implantable pump is also disclosed, which does not require a complicated clinching system or the like, and which may include an undulating membrane and chamber design to reduce the height of the pump.
대표청구항
▼
1. An implantable device for dispensing an active substance to a patient comprising: a housing having top and bottom portions defining an active substance chamber in fluid communication with an outlet for delivering said active substance to a target site within said patient, and a propellant chamber
1. An implantable device for dispensing an active substance to a patient comprising: a housing having top and bottom portions defining an active substance chamber in fluid communication with an outlet for delivering said active substance to a target site within said patient, and a propellant chamber adjacent said active substance chamber, the top portion including a replenishment opening; and,an undulating flexible membrane separating said active substance and propellant chambers, said undulating flexible membrane having a first position when said active substance chamber is empty and a second position when said active substance chamber contains an active substance,wherein said top portion has an undulating interior surface including a continuously curved central convex portion flanked by at least two continuously curved concave portions and said undulating flexible membrane has a continuously curved central concave portion flanked by at least two continuously curved convex portions in both the first and second positions, said undulating interior surface cooperating with said undulating flexible membrane in the first position, and wherein said replenishment opening is located within said central convex portion of said undulating interior surface so as to lower an overall height of said implantable device,wherein said undulating interior surface of said top portion and said concave and convex portions of said undulating flexible membrane include no flat portions. 2. The implantable device according to claim 1, wherein the propellant chamber contains a propellant capable of expanding isobarically, the propellant cooperating with said undulating flexible membrane to reduce the volume of the active substance chamber upon expansion of the propellant. 3. The implantable device according to claim 2, wherein the cooperating undulating surface and said undulating flexible membrane meet upon complete expansion of the propellant. 4. The implantable device according to claim 1, further comprising a first septum sealing said replenishment opening. 5. The implantable device according to claim 4, further comprising an annular opening in said housing communicating with said outlet, and a second septum sealing the annular opening. 6. The implantable device according to claim 1, further comprising means for varying the flow rate of said active substance between said active substance chamber and said outlet. 7. The implantable device according to claim 6, wherein said means includes an elongated polymer filament having a cross sectional dimension, the filament capable of being elongated to reduce the cross sectional dimension. 8. The implantable device according to claim 7, further including a capillary in fluid communication between said chamber and said outlet, wherein the filament is located eccentrically within said capillary. 9. The implantable device according to claim 8, wherein the filament has a uniform cross section along its length. 10. The implantable device according to claim 8, wherein the filament has a non-uniform cross section along its length. 11. The implantable device according to claim 7, further comprising means for elongating the filament. 12. The implantable device according to claim 11, wherein said means for elongating the filament includes an axle driven by a motor. 13. The implantable device according to claim 6, further comprising means for controlling said means for varying the flow rate of said active substance between said chamber and said outlet. 14. The implantable device according to claim 13, wherein the means for controlling are wireless. 15. The implantable device according to claim 1, further comprising a capillary in fluid communication between said active substance chamber and said outlet, said capillary having an inner surface, and a flow control element received within said capillary, said element having an outer surface opposing said inner surface of said capillary defining therebetween a passageway for the flow of said active substance therethrough, said outer surface of said element moveable relative to said inner surface of said capillary to alter the flow of said active substance therethrough. 16. The implantable device according to claim 1, wherein said top and bottom portions are constructed so as to screw together. 17. The implantable device according to claim 16, wherein said top and bottom portions of said housing are constructed of polyetherehterketone. 18. The implantable device according to claim 1, wherein said top portion and said bottom portion capture said membrane therebetween. 19. The implantable device according to claim 18, wherein said top portion and said bottom portion form means for retaining said membrane therebetween. 20. The implantable device according to claim 18, wherein said housing further comprises a locking portion which may be screwed into either or both of said top portion or said bottom portion to retain said top portion and said bottom portion together. 21. The implantable device according to claim 20, wherein said housing further comprises a septum retaining member for retaining a replenishment septum covering the replenishment opening. 22. The implantable device according to claim 1, wherein said active substance chamber is defined by said undulating interior surface and said undulating flexible membrane. 23. An implantable device for dispensing an active substance to a patient comprising: a housing defining an active substance chamber in fluid communication with an outlet for delivering said active substance to a target site within said patient, and a propellant chamber, said housing having a top portion and a bottom portion, said top portion including a replenishment opening in communication with said chamber and located within a continuously curved central convex portion so as to lower an overall height of said implantable device; and,an undulating flexible membrane separating said active substance and propellant chambers, having a first position when said active substance chamber is empty and a second position when said active substance chamber contains an active substance, said undulating flexible membrane including a continuously curved central concave portion in both the first and second positions that cooperates with the central convex portion of said top portion while in the first position,wherein the continuously curved central convex portion of said top portion and the continuously curved central concave of said undulating flexible membrane include no flat portions and the first portion and the second portion are constructed of polyetherehterketone and screwed together. 24. The implantable device according to claim 23, wherein the propellant chamber contains a propellant capable of expanding isobarically, the propellant cooperating with said flexible membrane to reduce the volume of the active substance chamber upon expansion of the propellant. 25. The implantable device according to claim 24, wherein said central convex portion and said undulating flexible membrane meet upon complete expansion of the propellant. 26. The implantable device according to claim 25, further comprising a first septum sealing said replenishment opening. 27. The implantable device according to claim 26, further comprising an annular opening in said housing communicating with said outlet, and a second septum sealing the annular opening. 28. The implantable device according to claim 23, further comprising means for varying the flow rate of said active substance between said active substance chamber and said outlet. 29. The implantable device according to claim 28, wherein said means includes an elongated polymer filament having a cross sectional dimension, the filament capable of being elongated to reduce the cross sectional dimension. 30. The implantable device according to claim 29, further including a capillary in fluid communication between said chamber and said outlet, wherein the filament is located eccentrically within said capillary. 31. The implantable device according to claim 30, wherein the filament has a uniform cross section along its length. 32. The implantable device according to claim 30, wherein the filament has a non-uniform cross section along its length. 33. The implantable device according to claim 29, further comprising means for elongating the filament. 34. The implantable device according to claim 33, wherein said means for elongating the filament includes an axle driven by a motor. 35. The implantable device according to claim 28, further comprising means for controlling said means for varying the flow rate of said active substance between said chamber and said outlet. 36. The implantable device according to claim 35, wherein the means for controlling are wireless. 37. The implantable device according to claim 23, further comprising a capillary in fluid communication between said active substance chamber and said outlet, said capillary having an inner surface, and a flow control element received within said capillary, said element having an outer surface opposing said inner surface of said capillary defining therebetween a passageway for the flow of said active substance therethrough, said outer surface of said element moveable relative to said inner surface of said capillary to alter the flow of said active substance therethrough. 38. The implantable device according to claim 23, wherein said active substance chamber is defined by said central convex portion and said undulating flexible membrane. 39. An implantable device for dispensing an active substance comprising: a housing including a top portion, a bottom portion and a locking portion, said housing defining a propellant chamber and an active substance chamber in fluid communication with an outlet, said top portion including a replenishment opening located within a continuously curved convex portion so as to lower an overall height of said implantable device; anda membrane retained between said top and bottom portions having a first position when said active substance chamber is empty and a second position when said active substance chamber contains an active substance, said membrane separating said active substance and propellant chambers and including a continuously curved concave portion in both the first and second positions that cooperates with the continuously curved convex portion of said top portion while in the first position,wherein the continuously curved convex portion of said top portion and the continuously curved concave portion of said membrane include no flat portions and said top and bottom portions are placed together and said locking portion is screwed into either or both of said top or bottom portions to retain said top and bottom portions together. 40. The implantable device according to claim 39, wherein said top and bottom portions form an attachment for retaining said membrane therebetween. 41. The implantable device according to claim 39, wherein the propellant chamber contains a propellant capable of expanding isobarically, the propellant cooperating with said flexible membrane to reduce the volume of the active substance chamber upon expansion of the propellant. 42. The implantable device according to claim 39, wherein said top portion further includes at least two continuously curved concave portions flanking said central convex portion. 43. The implantable device according to claim 42, further comprising a first septum sealing said replenishment opening. 44. The implantable device according to claim 43, further comprising an annular opening in said housing communicating with said outlet, and a second septum sealing the annular opening. 45. The implantable device according to claim 44, wherein said housing further comprises a septum retaining member for retaining said first septum. 46. The implantable device according to claim 42, wherein said active substance chamber is defined by said concave and convex portions and said membrane. 47. The implantable device according to claim 39, wherein said top, bottom and locking portions are constructed from polyetherehterketone.
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